Patents by Inventor Ehud Ivri
Ehud Ivri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11278448Abstract: Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.Type: GrantFiled: December 7, 2018Date of Patent: March 22, 2022Assignee: Kedalion Therapeutics, Inc.Inventors: Daniel Palanker, Mark Blumenkranz, Ehud Ivri, Reynaldo Quintana
-
Publication number: 20200315842Abstract: Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.Type: ApplicationFiled: December 7, 2018Publication date: October 8, 2020Inventors: Daniel Palanker, Mark Blumenkrantz, Ehud Ivri, Reynaldo Quintana
-
Publication number: 20190314198Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.Type: ApplicationFiled: June 18, 2019Publication date: October 17, 2019Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
-
Publication number: 20190314197Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.Type: ApplicationFiled: June 18, 2019Publication date: October 17, 2019Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
-
Publication number: 20190314196Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.Type: ApplicationFiled: June 18, 2019Publication date: October 17, 2019Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
-
Publication number: 20190314195Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.Type: ApplicationFiled: June 18, 2019Publication date: October 17, 2019Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
-
Patent number: 8336545Abstract: A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 ?g to about 500 mg of a medicament. Also a method of treating a patient with a pulmonary disease, the method comprising administering an aerosolized first medicament comprising amikacin to the patient and administering, systemically a second medicament comprising an antibiotic to the patient that also treats the pulmonary disease, wherein a resulting amikacin concentration in the lung and/or pulmonary system is therapeutically-effective, and an amount of the systemically administered antibiotics is reduced.Type: GrantFiled: January 16, 2007Date of Patent: December 25, 2012Assignee: Novartis Pharma AGInventors: James B. Fink, John Power, Ehud Ivri, Kevin J. Corkery
-
Patent number: 8196573Abstract: A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.Type: GrantFiled: January 23, 2008Date of Patent: June 12, 2012Assignee: Novartis AGInventors: James B. Fink, John Power, Ehud Ivri, Niall Smith, Paul Dunne, Gavan O'Sullivan, Declan Moran, Keith Gibbons
-
Patent number: 7971588Abstract: A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 ?g to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.Type: GrantFiled: March 24, 2005Date of Patent: July 5, 2011Assignee: Novartis AGInventors: James B. Fink, John Power, Ehud Ivri, Niall Smith, Paul Dunne, Gavan O'Sullivan, Declan Moran, Keith Gibbons
-
Patent number: 7946291Abstract: A pressure-assisted breathing system comprises a pressure-generating circuit for maintaining a positive pressure within the system, and a patient interface device coupled to a patient's respiratory system. A respiratory circuit is positioned between the pressure-generating circuit and the patient interface device and a nebulizer is coupled to the respiratory circuit.Type: GrantFiled: April 20, 2004Date of Patent: May 24, 2011Assignee: Novartis AGInventors: James Fink, Ehud Ivri
-
Publication number: 20080142002Abstract: A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.Type: ApplicationFiled: January 23, 2008Publication date: June 19, 2008Applicant: Aerogen, Inc.Inventors: James B. Fink, John Power, Ehud Ivri, Niall Smith, Paul Dunne, Gavan O'Sullivan, Declan Moran, Keith Gibbons
-
Publication number: 20080017198Abstract: A pressure-assisted breathing system is provided that comprises: a pressure-generating circuit for maintaining a positive pressure within the system; a patient interface device coupled to a patient's respiratory system; a respiratory circuit for providing gas communication between the pressure-generating circuit and the patient interface device; means for introducing aerosol particles into the gas flow in the respiratory circuit; and means for discontinuing the introduction of aerosol particles into said respiratory circuit gas flow when the patient exhales. In one embodiment, a flow sensor is disposed in an auxiliary circuit in fluid communication with the respiratory circuit and electronically coupled with a nebulizer. The flow sensor is adapted to detect changes in the volumetric flow rate of gas in the auxiliary circuit when the patient exhales and stops exhaling and sends corresponding electronic signals to the nebulizer to turn off and turn on, respectively.Type: ApplicationFiled: August 6, 2007Publication date: January 24, 2008Applicant: Aerogen, Inc.Inventor: Ehud Ivri
-
Publication number: 20070267010Abstract: A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 ?g to about 500 mg of a medicament. Also a method of treating a patient with a pulmonary disease, the method comprising administering an aerosolized first medicament comprising amikacin to the patient and administering, systemically a second medicament comprising an antibiotic to the patient that also treats the pulmonary disease, wherein a resulting amikacin concentration in the lung and/or pulmonary system is therapeutically-effective, and an amount of the systemically administered antibiotics is reduced.Type: ApplicationFiled: January 16, 2007Publication date: November 22, 2007Inventors: James Fink, John Power, Ehud Ivri, Kevin Corkery
-
Patent number: 7290541Abstract: A pressure-assisted breathing system comprises a flow generator, a circuit connecting the flow generator to a patient's respiratory system and an aerosol generator for emitting aerosol particles into the circuit, wherein the circuit defines a path for the emitted aerosol particles having a change in angle no greater than 15°.Type: GrantFiled: June 30, 2004Date of Patent: November 6, 2007Assignee: Aerogen, Inc.Inventors: Ehud Ivri, James Fink
-
Patent number: 7267121Abstract: A pressure-assisted breathing system is provided that comprises: a pressure-generating circuit for maintaining a positive pressure within the system; a patient interface device coupled to a patient's respiratory system; a respiratory circuit for providing gas communication between the pressure-generating circuit and the patient interface device; means for introducing aerosol particles into the gas flow in the respiratory circuit; and means for discontinuing the introduction of aerosol particles into said respiratory circuit gas flow when the patient exhales. In one embodiment, a flow sensor is disposed in an auxiliary circuit in fluid communication with the respiratory circuit and electronically coupled with a nebulizer. The flow sensor is adapted to detect changes in the volumetric flow rate of gas in the auxiliary circuit when the patient exhales and stops exhaling and sends corresponding electronic signals to the nebulizer to turn off and turn on, respectively.Type: GrantFiled: September 30, 2004Date of Patent: September 11, 2007Assignee: Aerogen, Inc.Inventor: Ehud Ivri
-
Publication number: 20050229928Abstract: A pressure-assisted breathing system comprises a flow generator, a circuit connecting the flow generator to a patient's respiratory system and an aerosol generator for emitting aerosol particles into the circuit, wherein the circuit defines a path for the emitted aerosol particles having a change in angle no greater than 15°.Type: ApplicationFiled: June 30, 2004Publication date: October 20, 2005Applicant: Aerogen, Inc.Inventors: Ehud Ivri, James Fink
-
Publication number: 20050229929Abstract: A pressure-assisted breathing system is provided that comprises: a pressure-generating circuit for maintaining a positive pressure within the system; a patient interface device coupled to a patient's respiratory system; a respiratory circuit for providing gas communication between the pressure-generating circuit and the patient interface device; means for introducing aerosol particles into the gas flow in the respiratory circuit; and means for discontinuing the introduction of aerosol particles into said respiratory circuit gas flow when the patient exhales. In one embodiment, a flow sensor is disposed in an auxiliary circuit in fluid communication with the respiratory circuit and electronically coupled with a nebulizer. The flow sensor is adapted to detect changes in the volumetric flow rate of gas in the auxiliary circuit when the patient exhales and stops exhaling and sends corresponding electronic signals to the nebulizer to turn off and turn on, respectively.Type: ApplicationFiled: September 30, 2004Publication date: October 20, 2005Applicant: AEROGEN, INC.Inventor: Ehud Ivri
-
Publication number: 20050229927Abstract: A pressure-assisted breathing system comprises a pressure-generating circuit for maintaining a positive pressure within the system, and a patient interface device coupled to a patient's respiratory system. A respiratory circuit is positioned between the pressure-generating circuit and the patient interface device and a nebulizer is coupled to the respiratory circuit.Type: ApplicationFiled: April 20, 2004Publication date: October 20, 2005Applicant: Aerogen, Inc.Inventors: James Fink, Ehud Ivri
-
Publication number: 20050217666Abstract: A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 ?g to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.Type: ApplicationFiled: March 24, 2005Publication date: October 6, 2005Applicant: Aerogen, Inc.Inventors: James Fink, John Power, Ehud Ivri, Niall Smith, Paul Dunne, Gavan O'Sullivan, Declan Moran, Keith Gibbons