Patents by Inventor Ehud Marom

Ehud Marom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sublingual delivery of glatiramer acetate
    Patent number: 10493122
    Abstract: The present invention provides Glatiramer acetate compositions in a non-gelling matrix, formulated for sublingual delivery.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: December 3, 2019
    Assignee: MAPI PHARMA LTD.
    Inventors: Yoram Sela, Ehud Marom, Nadav Bleich Kimelman
  • Process and intermediates for the preparation of perampanel
    Patent number: 10111867
    Abstract: The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: October 30, 2018
    Assignee: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Shai Rubnov
  • Amorphous form of apremilast
    Patent number: 9994522
    Abstract: The present invention provides a new amorphous form of apremilast, pharmaceutical compositions comprising same, methods for preparation and use thereof in treating conditions mediated by inhibition of TNF-? production or inhibition of phosphodiesterase 4 (PDE4), e.g., psoriatic arthritis and other chronic inflammatory diseases.
    Type: Grant
    Filed: July 20, 2014
    Date of Patent: June 12, 2018
    Assignee: MAPI PHARMA LTD.
    Inventors: Shai Rubnov, Ehud Marom
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL
    Publication number: 20180008584
    Abstract: The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.
    Type: Application
    Filed: February 17, 2015
    Publication date: January 11, 2018
    Applicant: MAPI PHARMA LTD.
    Inventors: Ehud MAROM, Shai RUBNOV
  • AMORPHOUS FORM OF APREMILAST
    Publication number: 20170174626
    Abstract: The present invention provides a new amorphous form of apremilast, pharmaceutical compositions comprising same, methods for preparation and use thereof in treating conditions mediated by inhibition of TNF-? production or inhibition of phosphodiesterase 4 (PDE4), e.g., psoriatic arthritis and other chronic inflammatory diseases.
    Type: Application
    Filed: July 20, 2014
    Publication date: June 22, 2017
    Applicant: MAPI PHARMA LTD.
    Inventors: Shai RUBNOV, Ehud MAROM
  • Intermediate compounds and process for the preparation of efinaconazole
    Patent number: 9617241
    Abstract: The present invention relates to a process for the preparation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (Efinaconazole) and intermediates used in such process.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: April 11, 2017
    Assignee: MAPI PHARMA LTD.
    Inventors: Anna Gopin, Shai Rubnov, Galina Zats, Ehud Marom
  • SUBLINGUAL DELIVERY OF GLATIRAMER ACETATE
    Publication number: 20170080044
    Abstract: The present invention provides Glatiramer acetate compositions in a non-gelling matrix, formulated for sublingual delivery.
    Type: Application
    Filed: March 16, 2015
    Publication date: March 23, 2017
    Applicant: MAPI PHARMA LTD.
    Inventors: Yoram SELA, Ehud MAROM, Nadav BLEICH KIMELMAN
  • INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF EFINACONAZOLE
    Publication number: 20160355500
    Abstract: The present invention relates to a process for the preparation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (Efinaconazole) and intermediates used in such process.
    Type: Application
    Filed: March 2, 2015
    Publication date: December 8, 2016
    Applicant: MAPI PHARMA LTD.
    Inventors: Anna GOPIN, Shai RUBNOV, Galina ZATS, Ehud MAROM
  • Polymorphs of darunavir
    Patent number: 9453024
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: September 27, 2016
    Assignee: Mapi Pharma Ltd.
    Inventor: Ehud Marom
  • STEM CELL BANK FOR PERSONALIZED MEDICINE
    Publication number: 20160122709
    Abstract: The present invention relates to a stem cell bank which stores stem cells collected from individuals throughout their entire life. The stem cell bank of the present invention stores stem cells of various types, which are obtained from a plurality of sources from a single individual. The present invention further relates to methods of personalized medicine that utilizes cells stored in a bank of the present invention, and to compositions of stem cells for the treatment of various types of diseases.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 5, 2016
    Applicant: STEM CELL MEDICINE LTD.
    Inventor: Ehud MAROM
  • Amorphous form of dolutegravir
    Patent number: 9206197
    Abstract: An amorphous form of dolutegravir sodium, pharmaceutical compositions comprising same, methods for its preparation and use thereof as an antiretroviral agent.
    Type: Grant
    Filed: September 2, 2012
    Date of Patent: December 8, 2015
    Assignee: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Shai Rubnov
  • Random pentapolymer for treatment of autoimmune diseases
    Patent number: 9200114
    Abstract: The present invention relates to a synthetic polypeptide which is a random linear pentapolymer comprising alanine, glutamic acid, lysine, tyrosine and phenylalanine and use thereof in treating autoimmune diseases, in particular multiple sclerosis.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: December 1, 2015
    Assignee: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Shai Rubnov
  • Intermediate compounds and processes for the preparation of quinoline derivatives such as laquinimod sodium
    Patent number: 9102592
    Abstract: The present invention relates to processes for the preparation of quinoline-3-carboxamide derivatives, such as sodium 5-chloro-3-(ethylphenylcarbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-olate (Laquinimod sodium). The present invention further relates to intermediates formed in such processes.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: August 11, 2015
    Assignee: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Michael Mizhiritskii, Shai Rubnov
  • Polymorphs of perampanel
    Patent number: 9096574
    Abstract: The present invention provides novel crystalline forms of perampanel, pharmaceutical compositions comprising same, methods for their preparation and uses thereof for treating seizures and epilepsy.
    Type: Grant
    Filed: January 1, 2013
    Date of Patent: August 4, 2015
    Assignee: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Shai Rubnov
  • POLYMORPHS OF DARUNAVIR
    Publication number: 20150148412
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Applicant: MAPI PHARMA LIMITED
    Inventor: Ehud MAROM
  • Co-crystals of dapagliflozin
    Patent number: 9006188
    Abstract: The present invention provides novel co-crystal forms of dapagliflozin, namely a dapagliflozin lactose co-crystal and a dapagliflozin asparagine co-crystal, to pharmaceutical compositions comprising same, methods for their preparation and uses thereof for treating type 2 diabetes.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: April 14, 2015
    Assignee: Mapi Pharma Ltd.
    Inventors: Ehud Marom, Shai Rubnov
  • Intermediate compounds and process for the preparation of lurasidone and salts thereof
    Patent number: 8981095
    Abstract: The present invention relates to a process for the preparation of Lurasidone or a pharmaceutically acceptable salt thereof, a compound useful for the treatment of schizophrenia and bipolar disorder. The present invention further relates to processes for the preparation of Lurasidone intermediates, and to certain novel intermediates obtained by such processes.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: March 17, 2015
    Assignee: Mapi Pharma Ltd.
    Inventors: Ehud Marom, Michael Mizhiritskii, Susanna Tchilibon, Shai Rubnov
  • Process and intermediates for the preparation of abiraterone acetate
    Patent number: 8975244
    Abstract: The present invention relates to a process for the synthesis of (3beta)17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates in such processes.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 10, 2015
    Assignee: Mapi Pharma Ltd.
    Inventors: Ehud Marom, Shai Rubnov, Michael Mizhiritskii
  • INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM
    Publication number: 20150051419
    Abstract: The present invention relates to processes for the preparation of quinoline-3-carboxamide derivatives, such as sodium 5-chloro-3-(ethylphenylcarbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-olate (Laquinimod sodium). The present invention further relates to intermediates formed in such processes.
    Type: Application
    Filed: August 28, 2014
    Publication date: February 19, 2015
    Applicant: MAPI PHARMA LTD.
    Inventors: Ehud MAROM, Michael MIZHIRITSKII, Shai RUBNOV
  • Polymorphs of darunavir
    Patent number: 8921415
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: December 30, 2014
    Assignee: Mapi Pharma Ltd.
    Inventor: Ehud Marom