Patents by Inventor Ei-ichi Negishi

Ei-ichi Negishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral ?-amino tertiary boronic esters
    Patent number: 10738064
    Abstract: The present disclosure relates to a novel, highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure alfa-amino tertiary boronic esters, and novel alfa-amino tertiary boronic acids and esters prepared by the method. More specifically, highly enantiospecific borylation of configurationally stable ?-N-Boc substituted tertiary organolithium species and HBpin has been developed to synthesize various alfa-amino tertiary boronic esters through the formation of a new C—B bond with excellent enantiopurities.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: August 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Ei-ichi Negishi, Shiqing Xu, Qingqing Qi, Xuena Yang
  • Novel Chiral Alfa-Amino Tertiary Boronic Esters
    Publication number: 20200079799
    Abstract: The present disclosure relates to a novel, highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure alfa-amino tertiary boronic esters, and novel alfa-amino tertiary boronic acids and esters prepared by the method. More specifically, highly enantiospecific borylation of configurationally stable ?-N-Boc substituted tertiary organolithium species and HBpin has been developed to synthesize various alfa-amino tertiary boronic esters through the formation of a new C—B bond with excellent enantiopurities.
    Type: Application
    Filed: July 23, 2019
    Publication date: March 12, 2020
    Applicant: Purdue Research Foundation
    Inventors: Ei-ichi Negishi, Shiqing Xu, Qingqing Qi, Xuena Yang
  • Processes for the synthesis of chiral 1-alkanols
    Patent number: 10000432
    Abstract: The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: June 19, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventor: Ei-ichi Negishi
  • PROCESSES FOR THE SYNTHESIS OF CHIRAL 1-ALKANOLS
    Publication number: 20160332940
    Abstract: The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 17, 2016
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Ei-ichi Negishi
  • Chiral organoalanes and their organic derivatives via zirconium-catalyzed asymmetric carboalumination of terminal alkenes
    Patent number: 6002037
    Abstract: The present invention describes the Zr-catalyzed asymmetric carboalumination of alkenes to produce chiral alkylalanes that can be converted to various chiral organic compounds, such as isoalkyl alcohols, in highly enantiomeric excess. More particularly, the asymmetric addition of alkylaluminums to terminal alkenes under the influence of a catalyst such as a chiral zirconocene derivative produces chiral alkylaluminums that can be oxidized to 2-alkyl-substituted products (particularly alcohols) in greater than 60% enantiomeric excess. The ee figures can often exceed 95%. The organoalanes produces by the inventive process can be converted to a wide variety of other organic compounds of interest in the production of vitamins, pharmaceuticals and other medicinally and biologically important compounds, including vitamins and antibiotics.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: December 14, 1999
    Assignee: Purdue Research Foundation
    Inventors: Ei-ichi Negishi, Denis Y. Kondakov