Patents by Inventor Eiichiro Hata

Eiichiro Hata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for production of dimeric alkaloids
    Patent number: 5037977
    Abstract: This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe.sup.3+ and (1) removing or inactivating the Fe.sup.3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source.In accordance with this invention, such dimeric alkaloid as vinblastine, leurosidin, and 3',4'-anhydrovinblastine which are useful as antineoplastic drugs can be produced in high yields.
    Type: Grant
    Filed: August 8, 1989
    Date of Patent: August 6, 1991
    Assignee: Mitsui Petrochemical Industries Ltd.
    Inventors: Hiroaki Tan, Naoya Sakamoto, Eiichiro Hata, Takeshi Ishitoku, Noriaki Kihara