Abstract: A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer, and an excipient.

Abstract: The present invention provides an internal combustion engine includes: a turbocharger arranged in exhaust passage; EGR passage branching off from the exhaust passage downstream of a turbine of the turbocharger and connected to intake passage; a burner device arranged in the exhaust passage between the turbine and the portion where the EGR passage branches off to increase exhaust temperature; a bypass passage branching off from the exhaust passage between the turbine and the burner device and connected to the EGR passage; and a bypass valve to adjust flow rate of exhaust gas passing through bypass passage. When flow rate of the exhaust gas is increased, the bypass valve is open, and part of the exhaust gas is guided to the bypass passage. The flow rate of the exhaust gas to be supplied to the burner device is reduced, and the ignition performance of the burner device is ensured.

Abstract: An internal combustion engine according to the present invention includes an exhaust treatment apparatus provided in an exhaust passage, and a burner apparatus provided upstream of the exhaust treatment apparatus to increase an exhaust temperature. The burner apparatus includes at least a fuel addition valve that allows fuel to be added into exhaust and ignition means for igniting the fuel added via the fuel addition valve. The fuel addition valve is driven open when fuel is added via the fuel addition valve. The amount of fuel added via the fuel addition valve per unit time is increased beyond a predetermined reference amount when the detected amount of intake air exceeds a predetermined threshold value. The probability of successful ignition by the ignition apparatus is increased, and a flame is prevented from being blown out. Thus, the burner apparatus can demonstrate sufficient ignition performance and sufficient combustion performance.

Abstract: An internal combustion engine according to the present invention includes an exhaust treatment apparatus provided in an exhaust passage, and a burner apparatus provided upstream of the exhaust treatment apparatus to raise exhaust temperature. A valve driving state of at least one of an intake valve and an exhaust valve is controlled so as to reduce a flow rate of exhaust gas passing through the burner apparatus when the flow rate of the exhaust gas is equal to or larger than a predetermined value. Possible flame blow-out in the burner apparatus can be prevented or suppressed to ensure sufficient ignition performance.

Abstract: Provided is a step-shaped drill bit including at least two stepped cutting edges that are axially provided. A cutting edge of a first step from a tip is formed so as to satisfy at least one of the following conditions. That is, a number of blades is smaller, a point angle of the cutting edge is larger, or a clearance angle of the cutting edge is larger than that of cutting edges of a second and subsequent step(s). As a result, a thrust resistance during a perforation can be reduced compared with a case in which the first step cutting edge is formed such that the number of blades, the point angle of the cutting edge and the clearance angle of the cutting edge are the same as those of the second and subsequent step(s).

Abstract: The present invention provides an exhaust purification device for an internal combustion engine including exhaust purification members in an exhaust passage downstream of the turbine of a turbocharger. This exhaust purification device for the internal combustion engine is provided with a heating gas supply unit to supply heating gas to the exhaust purification members, a heating gas supply unit including a catalyst that is provided in the exhaust passage between the turbine and the exhaust purification member and has an oxidative function, a fuel addition means located upstream of the catalyst and a heating means located upstream of the catalyst. The fuel addition means and heating means are provided in a chamber that communicates with the exhaust passage between the turbine and the catalyst.

Abstract: An exhaust purification system for an internal combustion engine is provided that can steadily maintain a NOx purification rate of a selective reduction catalyst to be high without allowing the fuel economy or marketability to deteriorate. The exhaust purification system includes a NO2—NOx ratio adjustment mechanism that causes a NO2—NOx ratio to change; and a NO2—NOx ratio perturbation controller that executes NO2—NOx ratio perturbation control so that a NO2 balance of the selective reduction catalyst in a predetermined time period, with NO2 adsorption being positive and NO2 release being negative, is 0. Herein, NO2—NOx ratio perturbation control is defined as control that alternately executes NO2 increase control to cause the NO2—NOx ratio to be greater than a reference value near 0.5, and NO2 decrease control to cause the NO2—NOx ratio to be less than the reference value.

Abstract: Disclosed is a cutting tool, including: a cutting edge including a coating from a rake face to a flank face, and has a relief angle of not less than 15 degrees, a material of the coating having a higher wear resistance than a base material of the cutting edge, and during cutting of a work, an edge of the coating on the rake face at a top of the cutting edge is worn by friction with the work; with a progress of a wear inward in a radial direction, an edge of the coating on the flank face at the top of the cutting edge is removed by friction with the work to expose the base material thereunder; and the exposed base material is worn by friction with the work to retract the flank face inward in the radial direction.

Abstract: An exhaust purification system for an internal combustion engine is provided that can maintain the NOx purification rate of a selective reduction catalyst at near the maximum thereof. The exhaust purification system is provided with an oxidation catalyst and CSF provided in the exhaust plumbing of the engine, a selective reduction catalyst that is provided in the exhaust plumbing on the downstream side of oxidation catalyst and CSF, and selectively reduces NOx in the exhaust, and a NO2 sensor that detects NO2 in the exhaust inside of the exhaust plumbing on the downstream side of the selective reduction catalyst. An ECU executes NO2-NOx ratio decrease processing to cause the NO2-NOx ratio corresponding to the ratio of NO2 to NOx in the exhaust flowing into the selective reduction catalyst to decrease, in a case of a detection value Vno2 from the NO2 sensor being greater than a predetermined value Vno2_th.

Abstract: A control system for a plant e.g. as a non-linear system, which is capable of properly suppressing interaction occurring between a plurality of control inputs and a plurality of controlled variables, thereby making it possible to properly control the controlled variables and easily design the control system. In the control system, each of a plurality of interaction suppression parameters for correcting the control inputs, respectively, such that the interaction is suppressed is calculated using a neural network constructed by using, out of the plurality of control inputs, a control input other than a control input corrected by a calculated interaction suppression parameter, as an input, and the interaction suppression parameter as an output.

Abstract: Internal combustion engine according to the invention comprises an exhaust treatment apparatus provided in an exhaust passage, a burner apparatus provided upstream of the exhaust treatment apparatus for increasing exhaust temperature, and a variable mechanism for varying valve timing of an exhaust valve. The variable mechanism is controlled in such a manner that, when a flow amount of exhaust gas passing through the burner apparatus is equal to or more than a predetermined value, the exhaust valve opens in the middle of piston descending during an expansion stroke. When the exhaust valve is opened at this timing, high-temperature exhaust or combustion gas existing in combustion chamber at this time is sent to the burner apparatus, making it possible to increase atmosphere gas temperature of the burner apparatus. Therefore, even when flow amount of exhaust gas is increased to the predetermined value or more, sufficient ignition performance can be ensured.

Abstract: An EGR control apparatus for an internal combustion engine, which is capable of properly controlling an inert gas amount of two types of EGR gas supplied to cylinders of the engine via two paths different from each other, thereby making it possible to ensure a stable combustion state, reduced exhaust emissions, and improve operability. The EGR control apparatus includes low-pressure and high-pressure EGR devices, and an ECU. The ECU controls the low-pressure and high-pressure EGR gas amounts according to engine speed and demanded torque, and when a combination of engine speed and demanded torque is in a predetermined region, the low-pressure and high-pressure EGR gas amounts are controlled such that inert gas in low-pressure EGR gas exceeds in amount inert gas in high-pressure EGR gas, and the former more exceeds the latter as engine speed is higher or demanded torque is larger.

Abstract: An EGR control apparatus for an internal combustion engine, which is capable of accurately controlling an inert gas amount and an inert gas ratio of two types of EGR gas supplied to cylinders of the engine via two paths different from each other, thereby making it possible to ensure a stable combustion state and reduced exhaust emissions. The EGR control apparatus includes a low-pressure EGR device, a high-pressure EGR device, and an ECU. The ECU calculates a target low-pressure opening, calculates an estimated value of an in-cylinder low-pressure inert gas flow rate, which is the estimated value of an inert gas amount included in low-pressure EGR gas supplied to the cylinders via an intake passage, calculates a target high-pressure opening using the estimated value, and controls low-pressure and high-pressure EGR control valves, using the target low-pressure opening and the target high-pressure opening.

Abstract: A catalyst degradation determination device is provided that can determine the degradation of a selective reduction catalyst with high precision while also suppressing a temporary decline in purification performance. By way of controlling a urea injection device, the catalyst degradation determination device increases, in a selective reduction catalyst in a state in which the storage amount is a maximum, the storage amount thereof by a detection reduced-amount portion DSTNH3—JD and then decreases the amount until it is determined that ammonia slip has occurred. Then, degradation is determined based on the time at which the slip determination flag FNH3—SLIP was set to “1” when fluctuating the storage amount. The detection reduced-amount portion DSTNH3—JD is set to a value that is larger than the storage capacity of the selective reduction catalyst in a degraded state and smaller than the storage capacity of the selective reduction catalyst in a normal state.

Abstract: A drill includes a pair of main cutting edges extending from a distal portion of the drill to a position close to a proximal end of the drill to entirely define a two-edge configuration, and a pair of auxiliary cutting edges extending between positions at the distal and proximal sides of a maximum diameter position to partly define a four-edge configuration. A ridgeline of each auxiliary cutting edge is located within an angle smaller than 90° from a ridgeline of the corresponding main cutting edge toward the rear in a rotation direction of the drill. The point angle of the auxiliary cutting edges increases at a higher rate than the point angle of the main cutting edges in a predetermined range from the maximum diameter position toward a distal end of the drill.

Abstract: A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer and an excipient.

Abstract: The present invention provides a controller for controlling a modeled plant robustly against disturbance. The controller comprises an estimator and a control unit. The estimator estimates disturbance applied to the plant. The control unit determines an input to the plant so that an output of the plant converges to a desired value. The input to the plant is determined to include a value obtained by multiplying the estimated disturbance by a predetermined gain. Since estimated disturbance is reflected in the input to the plant, control having robustness against disturbance is implemented. The controller may comprise a state predictor. The state predictor predicts the output of the plant based on the estimated disturbance and dead time included in the plant. The control unit determined the input to the plant so that the predicted output converges to a desired value. Since the state predictor allows for the dead time, the accuracy of the control is improved.

Abstract: A control system for a plant is disclosed. The control system includes a controller for controlling the plant based on a controlled object model which is obtained by modeling the plant. The controlled object model is modeled using an input and an output of the plant which are sampled at intervals of a sampling period which is longer than a control period of the controller. The sampled input of the plant is a filtered control output which is obtained by filtering an output of the controller. The controller carries out a control process of the plant at intervals of the control period.

Abstract: A control system for a plant is disclosed. The control system includes a controller which controls the plant based on a controlled object model which is obtained by modeling the plant. The controlled object model is modeled using an input and an output of the plant which are sampled at intervals of a period which is longer than a control period of the controller. The controller carries out a control process of the plant at intervals of the control period.

Abstract: The present invention provides a controller for controlling a modeled plant robustly against disturbance. The controller comprises an estimator and a control unit. The estimator estimates disturbance applied to the plant. The control unit determines an input to the plant so that an output of the plant converges to a desired value. The input to the plant is determined to include a value obtained by multiplying the estimated disturbance by a predetermined gain. Since estimated disturbance is reflected in the input to the plant, control having robustness against disturbance is implemented. The controller may comprise a state predictor. The state predictor predicts the output of the plant based on the estimated disturbance and dead time included in the plant. The control unit determined the input to the plant so that the predicted output converges to a desired value. Since the state predictor allows for the dead time, the accuracy of the control is improved.