Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.

Abstract: A current detection circuit included in a power supply detects a current flowing to an inductance element from a detection tap of an inductance element connected between an output terminal and an output of a first switching element. A control circuit included in the power supply controls a first control terminal of the first switching element and a second control terminal of a second switching element and calculates an output current flowing to a load based on the current detected by the current detection circuit.

Abstract: A current detection circuit included in a power supply detects a current flowing to an inductance element from a detection tap of an inductance element connected between an output terminal and an output of a first switching element. A control circuit included in the power supply controls a first control terminal of the first switching element and a second control terminal of a second switching element and calculates an output current flowing to a load based on the current detected by the current detection circuit.

Abstract: A DC/DC converter 10 of the present invention is provided with a constant-voltage power supply circuit 11; a SENSE+ terminal; a SENSE?/OCPSEL terminal pulled up to a predetermined voltage VL through a pull-up resistor R8; and a controller 14 for controlling the constant-voltage power supply circuit 11, wherein the controller 14 controls the output voltage Vout of the constant-voltage power supply circuit 11 on the basis of a potential difference between the SENSE+ terminal and the SENSE?/OCPSEL terminal, on the condition that the voltage of the SENSE?/OCPSEL terminal is lower than a threshold voltage, and sets predetermined control parameters on the basis of the voltage of the SENSE?/OCPSEL terminal, on the condition that the voltage of the SENSE?/OCPSEL terminal is equal to or higher than the threshold voltage.

Abstract: A DC/DC converter 10 of the present invention is provided with a constant-voltage power supply circuit 11; a SENSE+ terminal; a SENSE?/OCPSEL terminal pulled up to a predetermined voltage VL through a pull-up resistor R8; and a controller 14 for controlling the constant-voltage power supply circuit 11, wherein the controller 14 controls the output voltage Vout of the constant-voltage power supply circuit 11 on the basis of a potential difference between the SENSE+ terminal and the SENSE?/OCPSEL terminal, on the condition that the voltage of the SENSE?/OCPSEL terminal is lower than a threshold voltage, and sets predetermined control parameters on the basis of the voltage of the SENSE?/OCPSEL terminal, on the condition that the voltage of the SENSE?/OCPSEL terminal is equal to or higher than the threshold voltage.

Abstract: An electronic musical instrument is provided with a temporal variation circuit of SCF parameters for temporally varying the filter characteristic of a switched capacitor filter circuit, a control circuit for digitally controlling the temporal variation circuit and a touch response circuit for detecting, by scanning, touch response data in performance, whereby temporal variations of a musical waveform signal are digitally controlled.

Abstract: An electronic musical instrument which has a keyboard and creates a musical tone by striking keys of the keyboard, is provided with an operation control circuit and an adder both for effecting keyboard switch chattering prevent operation processing and touch response select operation processing, a timing control circuit for controlling the switching between the chattering preventing operation and the touch response detecting operation and the scanning of the keyboard switches to detect their status, a musical tone generator for performing a musical tone generating operation asynchronously with the keyboard switch scanning operation, the keyboard switch chattering preventing operation and the touch response detecting operation, and a transfer circuit for transferring touch response information to the musical tone generator.

Abstract: In an electronic musical instrument which generates a musical waveform by calculating the waveform amplitude value at each sample point through Fourier synthesis, note-range variations of the musical waveform and its timbre variations in accordance with a touch response are controlled with respect to readout addresses for reading out a set of harmonic coefficient data for the Fourier synthesis from a memory having stored therein a plurality of sets of such harmonic coefficient data, thereby changing the component ratio of a harmonic coefficient which will ultimately be used as a Fourier coefficient.

Abstract: In an electronic musical instrument which generates a musical waveform by calculating the waveform amplitude value at each sample point through Fourier synthesis, temporal variations of the musical waveform and its timbre variations in accordance with a touch response are controlled with respect to readout addresses for reading out a set of harmonic coefficient data for the Fourier synthesis from a memory having stored therein a plurality of sets of such harmonic coefficient data, thereby changing the component ratio of a harmonic coefficient which will ultimately be used as a Fourier coefficient.

Abstract: In an electronic musical instrument which generates a musical waveform by calculating the waveform amplitude value at each sample point through Fourier synthesis, there is provided a musical waveform generator for caculating and synthesizing a temporally varying musical waveform at a plurality of sample points, memory circuits for storing two kinds of musical waveforms obtained by the musical waveform generator one after the other and an interpolation circuit for interpolating the two musical waveforms at time intervals shorter than the time intervals used in the musical waveform generator.

Abstract: An automatic fitting device for fitting an elastic annular ring such as an O-ring or the like on the outer circumferential groove of an article such as a piston or the like. The device includes a support for supporting the article thereon, a guide having a conically shaped surface with the large diameter end of which is adapted for abutting at one end surface of the article supported on the support, a piece for moving the elastic annular ring fitted on the conical surface along the conical surface with the diameter of the ring being enlarged and thus pushing the ring onto the article and fitting the ring into the circumferential groove of the article, and a structure for supporting the guide when the guide is not abutting at the article.

Abstract: A device for fitting an elastic ring such as a piston seal, O-ring or the like into an inner circumferential groove of an article such as a hydraulic cylinder or the like. The device comprises a support supporting the article, a tubular retaining member having an inner circumferential groove, means supplying the elastic ring transversely into the groove of the retaining member through a cut-out portion formed in the retaining member, a chucking member adapted to be inserted into the retaining member and into the article for receiving the elastic ring from the retaining member and delivering the elastic ring into the article, means for deforming elastically at least a portion of the elastic ring radially inwardly in delivering the elastic ring from the retaining member to the chucking member, and a clamping mechanism provided on the chucking member for clamping the elastically deformed ring in translating the chucking member from the retaining member to the article.