Abstract: Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to &agr;4&bgr;7 integrin and a selectivity toward &agr;4&bgr;1 integrin. They are used as therapeutic agents for various diseases to which &agr;4&bgr;7 integrin relates.

Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &agr; 4 integrin. They are used as therapeutic agents for various diseases concerning &agr; 4 integrin.

Abstract: An surface light emitting device that is capable of emitting light of high luminance with higher uniformity is disclosed. The surface light emitting device comprising; a light guide plate, a reflector on the under surface of the light guide plate and, an LED light source having at least one LED element and provided so that a light emitted by the LED element is incident on at least one end face of the light guide plate, wherein the light guide plate has a light diffusing portion on the one end face so that a light emitted from the LED light source enters the light guide plate while being diffused therein, and the light diffusing portion has the top end being space from the top surface.

Abstract: Phenylalanine derivatives of the following formulae and analogues thereof have an antagonistic activity to &agr;4 integrin. They are used as therapeutic agents for various diseases concerning &agr;4 integrin.

Abstract: Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to &agr;4&bgr;7 integrin and a selectivity toward &agr;4&bgr;1 integrin. They are used as therapeutic agents for various diseases to which &agr;4&bgr;7 integrin relates.

Abstract: To provide an optical waveguide that can emit light of which intensity is uniformly distributed over the light emitting surface and can suppress the occurrence of the bright line, the optical waveguide of surface light emitting apparatus has a light emitting plane and a reflecting plane that oppose each other, the reflecting surface having a plurality of dots formed thereon so that light entering from a light source that is provided on one end face or two opposing end faces is output through the light emitting surface with uniform intensity, wherein the dots are arranged so as to form band regions each being defined as a region that has a constant density of distribution, a plurality of vertical lines of the dots are formed at substantially equal intervals in each of the band regions in the direction toward adjacent bands, and the interval between the vertical lines of dots is made different in different bands.

Abstract: Herein disclosed are novel cephem compounds represented by the following general formula (I), and novel antimicrobial, and especially anti-MRSA, agents which contain as an active ingredient at least one of the novel cephem compounds and the physiologically acceptable salts thereof.

Abstract: In a magnetic disk device having a composite head with an induction type of recording head adjacent a magneto-resistance effect type of reproducing head, a read error relief is provided to relieve read errors caused by Barkhausen Noise or Base Line Shift phenomenon inherent to the magneto-resistance effect type of reproducing head. Upon occurrence of a read error, a re-try function is first executed, and a track offset function is executed for relief of the read error. However, if the read error is not relieved after the offset operation and the re-try operation have been performed a predetermined number of times, then a pseudo write-in and/or read current control operation is performed together with the offset operation and/or re-try operation for a predetermined number of times. The control operation varies the magnetic domain structure in the head magnetic film (MR film).

Abstract: (S)-1phenyl-1,3-propanediol or a derivative thereof having high optical purity can be produced simply in high yield, by contacting 1-phenylpropan-3-ol-1-one with a culture of microorganisms, microorganism cells isolated from the culture, or a product obtained by processing the microorganism cells.

Abstract: Herein is disclosed a process for producing a .beta.-ketoalcohol by the oxidative ring-opening reaction of a 1,3-dioxane derivative, said .beta.-ketoalcohol being able to be a substrate for asymmetric reaction.

Abstract: A magnetic disk apparatus has a disk assembly including a single servo disk and a plurality of data disks, a servo-head supporting structure for supporting a servo head and data-head supporting structures for supporting data heads. These heads are so disposed as to cooperate with respective disks. The servo-head and data-head supporting structures are driven by an actuator to move the servo head and the data heads to the required positions on the corresponding disks. The servo-head supporting structure and each of the data-head supporting structures have different proper oscillations to prevent the occurrence of a resonance during a seek operation.

Abstract: A 5-substituted-3-isoxazolecarboxylic acid derivative of the general formula: ##STR1## wherein X stands for a phenyl group, thienyl group, furyl group or pyridyl group, each of which optionally may carry at least one substituent group; R stands for a phenyl group or hydroxyphenyl group; and A stands for a group of the formula: ##STR2## wherein Y stands for ##STR3## in which the carbon atom with which the carboxyl group combines with the nitrogen atom in A, M stands for a hydrogen atom or a substituent group, and Z stands for a hydrogen atom, hydroxy group, acyloxy group, carbamoyloxy group, aromatic heterocycle thio group or aromatic nitrogen-containing heterocycle quaternary ammonium group, is disclosed along with methods for producing these compounds.

Abstract: A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;and where R is a radical selected from hydrogen, an organic radical such as alkyl, aryl or aralkyl or a heterocyclic group, said organic radical and heterocyclic group being optionally substituted;said method comprising reacting a compound represented by the following formula: ##STR2## with 4-pyridineethanesulfonic acid in an aqueous solution of sodium iodide and subsequently recovering the salt.

Abstract: A reactive derivative of imidazolecarboxylic acid having the formula: ##STR1## is useful in preparing imidazoledicarboxylic acid derivatives of alpha-aminopenicillins and cephalosporins.