Abstract: A wire coating removal device includes: a wire feed path; a pair of first rotary tools that remove a coating of the wire at a first position on the wire feed path; a first rotary drive mechanism that rotationally drives the pair of first rotary tools; a pair of second rotary tools that remove the coating of the wire at a second position; a second rotary drive mechanism that rotationally drives the pair of second rotary tools; a first tool distance changing mechanism that makes the pair of first rotary tools approach or separates from each other; and a second tool distance changing mechanism that makes the pair of second rotary tools approach or separates from each other, wherein the pair of first rotary tools remove a part of the coating of the wire, and the pair of second rotary tools then remove a remainder of the coating.

Abstract: A spring forming machine includes: a forming tool slide mechanism including a slider with a forming tool; a first lifting mechanism including a slider with a pitch tool; a second lifting mechanism including a slider with a cutting tool; a fixing base to which the wire feeder and the forming tool slide mechanism are attached; a lifting base to which the cored bar, the first lifting mechanism, and the second lifting mechanism are attached; a plurality of servo motors serving as drive sources; a controller controlling the servo motors; an individual drive control unit individually driving the servo motors; and an interlocking control unit that, when the servo motor of the lifting base is individually operated, interlocks the servo motors of the lifting base and the first lifting mechanism and, when the servo motor of the first lifting mechanism is individually operated, does not interlock the servo motors thereof.

Abstract: A spring forming machine includes: a forming tool slide mechanism including a slider with a forming tool; a first lifting mechanism including a slider with a pitch tool; a second lifting mechanism including a slider with a cutting tool; a fixing base to which the wire feeder and the forming tool slide mechanism are attached; a lifting base to which the cored bar, the first lifting mechanism, and the second lifting mechanism are attached; a plurality of servo motors serving as drive sources; a controller controlling the servo motors; an individual drive control unit individually driving the servo motors; and an interlocking control unit that, when the servo motor of the lifting base is individually operated, interlocks the servo motors of the lifting base and the first lifting mechanism and, when the servo motor of the first lifting mechanism is individually operated, does not interlock the servo motors thereof.

Abstract: A grinding apparatus includes: a pair of rotary grindstones, a rotary base rotationally driven around a first rotation axis, a rotary table included in the rotary base, a fixed base rotatably supporting the rotary base, a fixed table included in the fixed base, a plurality of workpiece supporting tables supported on the rotary base and rotationally driven around a second rotation axis, a plurality of workpiece receiving holes vertically passing through an outer edge part of the workpiece supporting tables, a first motor fixed to the fixed base to rotationally drive the rotary table, a plurality of second motors fixed to the rotary base to rotationally drive the workpiece supporting tables, a controller driving the first motor and the plurality of second motors, and a slip ring disposed below the plurality of second motors and conductively connecting between the controller and the plurality of second motors.

Abstract: Antibodies 9-10.2 and 8-4.1 that recognize YFGKLESK, which is 8 amino acids present in a neoepitope formed as a result of a precursor pro-IL-18 being cleaved by caspase-1 or caspase-4 are prepared. Accordingly, an antibody that recognizes only activated IL-18 can be provided.

Abstract: The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs. The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 678-757 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/34 H1N1 (SEQ ID NO: 2) and a polypeptide consisting of an amino acid sequence at positions 1-37 of RNA polymerase PB2 subunit in influenza A/Puerto Rico/8/34 H1N1 (SEQ ID NO: 4). This complex can be crystallized in the presence of a precipitant such as potassium phosphate and PEG4000. Moreover, with the use of information on the crystal structure of this complex, it is possible to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs.

Abstract: The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs which target a protein highly conserved among influenza virus species. The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 239-716 of the RNA polymerase PA subunit in influenza A/Puerto Rico/8/1934 H1N1 and a polypeptide consisting of an amino acid sequence at positions 1-81 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/1934 H1N1, as well as a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs, which comprises the step of selecting a substance which inhibits the interaction between ?-subunit and ?-subunit 1, each constituting influenza virus RNA polymerase, in the presence of a candidate substance.

Abstract: The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs. The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 678-757 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/34 H1N1 and a polypeptide consisting of an amino acid sequence at positions 1-37 of RNA polymerase PB2 subunit in influenza A/Puerto Rico/8/34 H1N1. This complex can be crystallized in the presence of a precipitant such as potassium phosphate and PEG4000. Moreover, with the use of information on the crystal structure of this complex, it is possible to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs.

Abstract: The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs which target a protein highly conserved among influenza virus species. The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 239-716 of the RNA polymerase PA subunit in influenza A/Puerto Rico/8/1934 H1N1 and a polypeptide consisting of an amino acid sequence at positions 1-81 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/1934 H1N1, as well as a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs, which comprises the step of selecting a substance which inhibits the interaction between ?-subunit and ?-subunit 1, each constituting influenza virus RNA polymerase, in the presence of a candidate substance.

Abstract: A first large drive gear for slider driving mechanisms and a second large drive gear for a tool rotating driving mechanism are disposed coaxially with an axis of a wire feeding quill and in parallel with a rear surface of a front base frame panel, and a single small drive gear and a plurality of small driven gears corresponding to a plurality of wire working units are disposed around each of these large drive gears. A plurality of slider driving mechanisms and at least one tool rotating driving mechanism are operated with a single common servomotor respectively.