Abstract: A lacrimal duct tube includes: a pair of tubular members that each have at one end an opening communicating with a lumen; and a connection member that connects the other ends of the tubular members. A base end part including the other end of at least one of the tubular members is tapered down toward the connection member and the base end part has an inlet/outlet port communicating with the lumen of the tubular member. A portion of the base end part constituting peripheral edge of the inlet/outlet port and the connection member are connected together.

Abstract: A lacrimal duct tube includes: a pair of tubular members that each have at one end an opening communicating with a lumen and have in a wall a hole for guiding a lacrimal duct tube operative instrument to the lumen; and a connection member that connects the other ends of the tubular members. Surfaces of the tubular members include a hydrophilic-coated portion and a non-coated portion without the hydrophilic coating. It is preferred that the lumen in the vicinity of the opening includes an engagement portion for engagement with a tip of the lacrimal duct tube operative instrument, and the non-coated portion is formed without overlapping with the surface of the tubular member at the position of the engagement portion. The lacrimal duct tube can be used favorably for various lacrimal duct obstruction treatments. In the case of using a sheath such as in sheath guided endoscopic probing, the lacrimal duct tube can be easily inserted into the sheath and be firmly fixed to the sheath.

Abstract: The present invention provides a lacrimal duct tube that can be preferably used for the treatment of lacrimal duct obstruction, in particular, sheath guided endoscopic probing having been frequently performed in recent years, the lacrimal duct tube being excellent in passage through a lesion in the lacrimal duct, operability in the lacrimal duct, and manipulation of the endoscope inserted into the lumen of the tube, and providing a sufficient viewing field of the endoscope. The present invention relates to a lacrimal duct tube, including: a pair of tubular members that each has an opening at one end and a hole in a side wall communicating with a lumen; and a connection member that connects other ends of the tubular members, wherein the tubular members each include a plurality of resin portions different in Shore hardness, at least one of the resin portions is positioned between the opening and the hole and forms a lumen wall of the tubular member, and the lumen wall has a Shore hardness of 57D or more.

Abstract: A lacrimal duct tube includes: a pair of tubular members that each have at one end an opening communicating with a lumen and have in a wall a hole for guiding a lacrimal duct tube operative instrument to the lumen; and a connection member that connects the other ends of the tubular members. Surfaces of the tubular members include a hydrophilic-coated portion and a non-coated portion without the hydrophilic coating. It is preferred that the lumen in the vicinity of the opening includes an engagement portion for engagement with a tip of the lacrimal duct tube operative instrument, and the non-coated portion is formed without overlapping with the surface of the tubular member at the position of the engagement portion. The lacrimal duct tube can be used favorably for various lacrimal duct obstruction treatments. In the case of using a sheath such as in sheath guided endoscopic probing, the lacrimal duct tube can be easily inserted into the sheath and be firmly fixed to the sheath.

Abstract: A lacrimal duct tube includes: a pair of tubular members that each have at one end an opening communicating with a lumen; and a connection member that connects the other ends of the tubular members. A base end part including the other end of at least one of the tubular members is tapered down toward the connection member and the base end part has an inlet/outlet port communicating with the lumen of the tubular member. A portion of the base end part constituting peripheral edge of the inlet/outlet port and the connection member are connected together.

Abstract: A primary surface of a normally-off field-effect transistor (102) on which a source electrode (120) is formed and a first primary surface of a die pad (105) are in contact with each other, and the die pad (105) also serves as a source terminal of a semiconductor device (100). Accordingly, a semiconductor device capable of decreasing an inductance, which is a matter of great importance for an operation of a cascode connection circuit, and improving performance of circuit operation is provided.

Abstract: The present invention provides a lacrimal duct tube that can be preferably used for the treatment of lacrimal duct obstruction, in particular, sheath guided endoscopic probing having been frequently performed in recent years, the lacrimal duct tube being excellent in passage through a lesion in the lacrimal duct, operability in the lacrimal duct, and manipulation of the endoscope inserted into the lumen of the tube, and providing a sufficient viewing field of the endoscope. The present invention relates to a lacrimal duct tube, including: a pair of tubular members that each has an opening at one end and a hole in a side wall communicating with a lumen; and a connection member that connects other ends of the tubular members, wherein the tubular members each include a plurality of resin portions different in Shore hardness, at least one of the resin portions is positioned between the opening and the hole and forms a lumen wall of the tubular member, and the lumen wall has a Shore hardness of 57D or more.

Abstract: The present invention provides a peptide which selectively adsorbs an anti-?1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-?1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-?1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-?1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.

Abstract: The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber. The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.

Abstract: Disclosed is (i) a compound which makes it possible to economically and easily detect or assay immunoglobulins under the same conditions regardless of animal species and (ii) a method for detecting or assaying an immunoglobulin through use of the compound. Use of a peptide carrying a labeling agent and having activity of binding to an immunoglobulin and an immunoglobulin complex makes it possible to economically and easily detect or assay immunoglobulins under the same conditions regardless of animal species.

Abstract: The present invention provides a peptide which selectively adsorbs an anti-?1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-?1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-?1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-?1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.

Abstract: The present invention aims to provide a contrast agent-removal system and a method of operating the system for efficiently removing the contrast agent which is cause of the renal function impairment. The system of the present invention includes a blood suction catheter which can be placed into the coronary sinus, a column for removing a contrast agent from the drawn blood, a blood drawing circuit for directing the blood into the column, a blood pump for controlling an amount of the drawn blood, a blood return circuit for returning the blood from which the contrast agent is removed to a patient's body and a device for measuring a blood suction pressure. In the method of operating the system, the blood is drawn with the blood suction catheter placed into the coronary sinus and the drawing blood is contacted with an adsorbent for adsorbing the contrast agent.

Abstract: The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber. The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.

Abstract: An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against ?1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive capacity.

Abstract: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Abstract: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Abstract: An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided. An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.

Abstract: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Abstract: The present invention has for its object to provide an adsorbent for an antibody against &bgr;1-adrenoceptor and/or an antibody against M2 muscarinic receptor, which is capable of efficient and selective adsorption of an antibody against &bgr;1-adrenoceptor and/or an antibody against M2 muscarinic receptor occurring in a body fluid without requiring a pretreatment of the body fluid. A further object is to provide an adsorption apparatus utilizing this adsorbent and a method for adsorbing an antibody against &bgr;1-adrenoceptor and/or an antibody against M2 muscarinic receptor.

Abstract: An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided.