Patents by Inventor Eiji Okanari
Eiji Okanari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10597375Abstract: A novel ?-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R1 is the same or different, and represents a halogen atom, or a C1-C3 alkyl group; R2 represents a hydrogen atom, or a C1-C6 alkyl group; p represents an integer of 0 to 5; V represents CR3 wherein R3 represents a hydrogen atom, an amino group, a nitro group, or a C1-C3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.Type: GrantFiled: May 8, 2018Date of Patent: March 24, 2020Assignee: UBE INDUSTRIES, LTD.Inventors: Noriaki Iwase, Hiroshi Nishida, Makoto Okudo, Masaaki Ito, Shigeyuki Kono, Masaaki Matoyama, Shigeru Ushiyama, Eiji Okanari, Hirofumi Matsunaga, Kenji Nishikawa, Tomio Kimura
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Publication number: 20180360803Abstract: The present invention provides the pharmaceutical use of LPA1 antagonists, for example, ?-halogenated thiophene compounds having a specific structure or pharmacologically acceptable salts thereof, as drugs for the treatment and/or prevention of NASH. A pharmaceutical composition for the treatment and/or prevention of NASH includes, as an active ingredient, an LPA1 antagonist, for example, a compound represented by the general formula (I): wherein R1 is a hydrogen atom or a methoxy group, R2 is a hydrogen atom or a C1-C6 alkyl group, X is a halogen atom, and A is a group selected from the group consisting of groups: , or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: November 18, 2016Publication date: December 20, 2018Applicant: UBE INDUSTRIES, LTD.Inventors: Kenji NISHIKAWA, Hirofumi MATSUNAGA, Yuuko SHINOHARA, Eiji OKANARI, Shigeru USHIYAMA, Shinpei NONOUCHI
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Publication number: 20180258062Abstract: A novel ?-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R1 is the same or different, and represents a halogen atom, or a C1-C3 alkyl group; R2 represents a hydrogen atom, or a C1-C6 alkyl group; p represents an integer of 0 to 5; V represents CR3 wherein R3 represents a hydrogen atom, an amino group, a nitro group, or a C1-C3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.Type: ApplicationFiled: May 8, 2018Publication date: September 13, 2018Applicant: UBE INDUSTRIES, LTD.Inventors: Noriaki IWASE, Hiroshi NISHIDA, Makoto OKUDO, Masaaki ITO, Shigeyuki KONO, Masaaki MATOYAMA, Shigeru USHIYAMA, Eiji OKANARI, Hirofumi MATSUNAGA, Kenji NISHIKAWA, Tomio KIMURA
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Patent number: 10023554Abstract: The invention provides a novel ?-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I): (wherein R is a hydrogen atom or a methoxy group; X is a halogen atom; A is selected from the group consisting of: M is an alkali metal or an alkaline earth metal; and n is 1 when M is an alkali metal and is 2 when M is an alkaline earth metal).Type: GrantFiled: June 26, 2015Date of Patent: July 17, 2018Assignee: UBE INDUSTRIES, LTD.Inventors: Noriaki Iwase, Hiroshi Nishida, Makoto Okudo, Masaaki Ito, Shigeyuki Kono, Masaaki Matoyama, Shigeru Ushiyama, Eiji Okanari, Hirofumi Matsunaga, Kenji Nishikawa, Tomio Kimura
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Patent number: 10000463Abstract: A novel ?-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided.Type: GrantFiled: June 26, 2015Date of Patent: June 19, 2018Assignee: UBE INDUSTRIES, LTD.Inventors: Noriaki Iwase, Hiroshi Nishida, Makoto Okudo, Masaaki Ito, Shigeyuki Kono, Masaaki Matoyama, Shigeru Ushiyama, Eiji Okanari, Hirofumi Matsunaga, Kenji Nishikawa, Tomio Kimura
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Publication number: 20170158663Abstract: The invention provides a novel ?-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I): (wherein R is a hydrogen atom or a methoxy group; X is a halogen atom; A is selected from the group consisting of: ;M is an alkali metal or an alkaline earth metal; and n is 1 when M is an alkali metal and is 2 when M is an alkaline earth metal).Type: ApplicationFiled: June 26, 2015Publication date: June 8, 2017Applicant: UBE INDUSTRIES, LTD.Inventors: Noriaki IWASE, Hiroshi NISHIDA, Makoto OKUDO, Masaaki ITO, Shigeyuki KONO, Masaaki MATOYAMA, Shigeru USHIYAMA, Eiji OKANARI, Hirofumi MATSUNAGA, Kenji NISHIKAWA, Tomio KIMURA
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Publication number: 20150376160Abstract: A novel ?-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R1 is the same or different, and represents a halogen atom, or a C1-C3 alkyl group; R2 represents a hydrogen atom, or a C1-C6 alkyl group; p represents an integer of 0 to 5; V represents CR3 wherein R3 represents a hydrogen atom, an amino group, a nitro group, or a C1-C3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.Type: ApplicationFiled: June 26, 2015Publication date: December 31, 2015Applicant: UBE INDUSTRIES, LTD.Inventors: Noriaki IWASE, Hiroshi NISHIDA, Makoto OKUDO, Masaaki ITO, Shigeyuki KONO, Masaaki MATOYAMA, Shigeru USHIYAMA, Eiji OKANARI, Hirofumi MATSUNAGA, Kenji NISHIKAWA, Tomio KIMURA
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Publication number: 20140113907Abstract: The present invention provides a pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. Since the pyridylaminoacetic acid compound has EP2 agonistic action, it is useful as a therapeutic or prophylactic drug for respiratory diseases such as asthma or chronic obstructive pulmonary disease.Type: ApplicationFiled: December 16, 2013Publication date: April 24, 2014Applicant: UBE INDUSTRIES, LTD.Inventors: Ryo IWAMURA, Masayuki TANAKA, Tetsushi KATSUBE, Manabu SHIGETOMI, Eiji OKANARI, Yasunori TOKUNAGA, Hiroshi FUJIWARA
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Patent number: 8685986Abstract: The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R1, R2, R3, Y, and Z are defined in the specification.Type: GrantFiled: March 30, 2010Date of Patent: April 1, 2014Assignee: Ube Industries, Ltd.Inventors: Masahiko Hagihara, Kenji Yoneda, Eiji Okanari, Manabu Shigetomi
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Patent number: 8648097Abstract: The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. The pyridylaminoacetic acid compound has EP2 agonistic action and is therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases such as asthma or chronic obstructive pulmonary disease.Type: GrantFiled: March 12, 2009Date of Patent: February 11, 2014Assignee: Ube Industries, Ltd.Inventors: Ryo Iwamura, Masayuki Tanaka, Tetsushi Katsube, Manabu Shigetomi, Eiji Okanari, Yasunori Tokunaga, Hiroshi Fujiwara
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Publication number: 20120259123Abstract: The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, a medical composition containing the same, and a medical composition for the treatment or prophylaxis of respiratory diseases or glaucoma.Type: ApplicationFiled: December 24, 2010Publication date: October 11, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Ryo Iwamura, Masayuki Tanaka, Tetsushi Katsube, Nobuhiko Shibakawa, Manabu Shigetomi, Eiji Okanari, Tomoko Kanda, Yasunori Tokunaga, Hiroshi Fujiwara
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Publication number: 20120226036Abstract: This is to provide a novel substituted carbonyl compound represented by the following formula (I) having an excellent bronchodilatory action based on potent EP2 agonistic action and useful for treatment of respiratory diseases. A compound represented by the following formula (I): or a salt thereof.Type: ApplicationFiled: September 10, 2010Publication date: September 6, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Masahiko Hagihara, Ryo Iwamura, Nobuhiko Shibakawa, Kenji Yoneda, Eiji Okanari, Takayuki Nakanishi
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Publication number: 20120190852Abstract: The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R1, R2 and R3 each independently represent a hydrogen atom or C1-C6 alkyl group, Y represents a bicyclic heteroaromatic ring group which may be substituted by a group(s) selected from the group consisting of a halogen atom, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group, halogeno C1-C6 alkoxyl group and C1-C6 alkylthio group or a group -Q1-Q2 wherein Q1 represents an arylene group or 5- to 6-membered heteroarylene group, Q2 represents an aromatic group or a 5- to 6-membered ring heterocyclic group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, hydroxyl group, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group and halogeno C1-C6 alkoxyl group, Z represents an aromatic group or a 5- to 6-membered heteroaromatic ring group eaType: ApplicationFiled: March 30, 2010Publication date: July 26, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Masahiko Hagihara, Kenji Yoneda, Eiji Okanari, Manabu Shigetomi
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Publication number: 20120184747Abstract: This is to provide a novel aniline compound represented by the following formula (I) having an excellent broncho dilatory action based on potent EP2 agonistic action. A compound represented by the formula (I): or a salt thereof.Type: ApplicationFiled: September 10, 2010Publication date: July 19, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Ryo Iwamura, Yoko Murakami, Masahiko Hagihara, Eiji Okanari
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Publication number: 20110054172Abstract: The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. The pyridylaminoacetic acid compound has EP2 agonistic action and is therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases such as asthma or chronic obstructive pulmonary disease.Type: ApplicationFiled: March 12, 2009Publication date: March 3, 2011Inventors: Ryo Iwamura, Masayuki Tanaka, Tetsushi Katsube, Manabu Shigetomi, Eiji Okanari, Yasunori Tokunaga, Hiroshi Fujiwara
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Patent number: 7309718Abstract: The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH?CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc.Type: GrantFiled: June 27, 2002Date of Patent: December 18, 2007Assignee: UBE Industries, Ltd.Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Ichiro Tanaka, Masayuki Tanaka, Masahiko Hagihara
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Publication number: 20040180884Abstract: The present invention discloses a dibenzocycloheptene compound represented by the formula (I): 1Type: ApplicationFiled: December 23, 2003Publication date: September 16, 2004Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Ichiro Tanaka, Masayuki Tanaka, Masahiko Hagihara
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Publication number: 20030216571Abstract: The present invention is to provide novel tricyclic compounds having leukotriene antagonistic action and represented by the formula: 1Type: ApplicationFiled: July 31, 2002Publication date: November 20, 2003Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Takashi Ikuta
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Patent number: 5591752Abstract: This invention relates to a compound (a quinoline derivative) represented by the formula (I): ##STR1## The quinoline derivative of this invention has a strong leukotriene antagonistic action and is extremely useful as an antiallergic medicine and an anti-inflammatory medicine.Type: GrantFiled: August 16, 1995Date of Patent: January 7, 1997Assignee: Ube Industries, Ltd.Inventors: Tomio Kimura, Yoshio Kaku, Takashi Ikuta, Hiroshi Fujiwara, Hitoshi Ueno, Eiji Okanari