Abstract: A gasket having a novel structure ensuring both the gas tightness and the low-friction slidability is provided. A sliding portion of the gasket (13) includes at least a first annular projection (17A), an annular recess and a second annular projection (17B) arranged in this order in a direction rearward from a distal portion of the gasket serving as a liquid contact portion. The first projection (17A) is designed so that a first peak appears adjacent the distal portion of the gasket when the gasket is fitted in the syringe barrel (11) and a product ? of a contact pressure P1f and a width D1f of the first peak is 0.4???1.0 as determined by an FEM analysis.

Abstract: A pre-filled syringe with excellent air-tightness and liquid-tightness and a mold for forming the gasket are provided. At least a surface of the mold for a gasket laminated with an inactive film for a pre-filled syringe forms a seal sliding surface of an annular protrusion of the gasket is mirror finished to have an arithmetic mean roughness Ra of less than 0.03 ?m.

Abstract: The present invention aims at providing a composite of a surface-modified fluororesin film and a thermoplastic resin bonded to each other, and medical equipment containing the composite. A method for producing a fluororesin/thermoplastic resin composite includes roughening a surface of a fluororesin film by ion beam irradiation from an ion source, and pressure-bonding the surface-modified fluororesin film obtained in the surface roughening step and a thermoplastic resin while maintaining the thermoplastic resin in a fluid state.

Abstract: A gasket having a novel structure ensuring both the gas tightness and the low-friction slidability is provided. A sliding portion of the gasket (13) includes at least a first annular projection (17A), an annular recess and a second annular projection (17B) arranged in this order in a direction rearward from a distal portion of the gasket serving as a liquid contact portion. The first projection (17A) is designed so that a first peak appears adjacent the distal portion of the gasket when the gasket is fitted in the syringe barrel (11) and a product ? of a contact pressure P1f and a width D1f of the first peak is 0.4???1.0 as determined by an FEM analysis.

Abstract: There are provided a method for manufacturing a surface-modified fluororesin film capable of long-term inventory storage, a method for manufacturing a rubber composite composed of the surface-modified fluororesin film and rubber bonded together, and a rubber product for medical use made of the rubber composite. The method for manufacturing a surface-modified fluororesin film comprises the step of performing surface roughening on a fluororesin film RF by applying an ion beam from an anode layer ion source to the surface of the fluororesin film RF. A rubber is placed over the roughened surface of the thusly produced surface-modified fluororesin film, and, through vulcanization molding process, the surface-modified fluororesin film and the tuber can be firmly bonded to each other.

Abstract: Disclosed is a closure device for a container, which seals an opening (6) that opens at the top of a container (2) and has a rim (7) on its periphery. The closure device comprises a seal member (8) that is to cover the opening (6) on the top of the container (2), and a synthetic resin cap (9) that is to press the seal member (8) against the upper surface of the rim (7). The seal member (8) comprises a flange (10) to be mounted on the upper surface of the rim (7). The cap (9) comprises a top wall (15), a cylinder part (16), and a locking part (18). The top wall (15) is to be disposed above the flange (10). The cylinder part (16) hangs down from the outer circumference of the top wall (15). The locking part (18) is disposed on the inner surface of the cylinder part (16). After the cap (9) is pushed down, the locking part (18) locks at the under surface of the rim (7). The upper surface of the flange (10) has a compressible projection (29).

Abstract: The present invention provides a gasket for glass or resin syringes which is laminated with an inert resin film and is excellent in plugging properties, liquid-tightness, and slidability. The gasket laminated with an inert resin film has multiple circular ribs that are to be in sliding contact with an inner wall of a syringe barrel, wherein the circular ribs include a front circular rib having a sliding contact portion whose cross section has a diameter that expands substantially linearly toward a back end of the syringe barrel, the linear portion has a length of 10 to 55% of the length of a sliding side face of the gasket, and the diameter of the linear portion which expands substantially linearly toward a back end of the syringe barrel has a diameter expansion ratio X between a minimum diameter r (mm) and a maximum diameter R (mm) of 0.1 to 8.0%.

Abstract: The present invention aims to provide a gasket which reduces the clamping force required to fit a plunger rod into the gasket, while maintaining a tight fit therebetween. The present invention relates to a medical gasket including a female screw portion to fit a plunger, on the side opposite to a drug contact surface, the female screw portion having roots or crests which gradually increase in diameter from the drug contact surface side toward the opposite plunger side.

Abstract: The present invention provides a gasket for syringes which can be stored for a long time without any chemical liquid leakage. The present invention relates to a gasket for syringes, including a film laminated to a surface of the gasket, the film having a liquid-contacting portion and a sliding portion, the liquid-contacting portion being thicker than the sliding portion. Preferably, the liquid-contacting portion has a thickness at least 1.2 times the thickness of the sliding portion.

Abstract: The present invention aims to provide a gasket for a pre-filled syringe which has excellent air-tightness and liquid-tightness and a mold for forming the gasket. The present invention relate to a mold for a gasket laminated with an inactive film for a pre-filled syringe, wherein at least a surface of the mold which forms a seal sliding surface of an annular protrusion of the gasket is mirror finished to have an arithmetic mean roughness Ra of less than 0.03 ?m.

Abstract: The present invention provides a gasket for glass or resin syringes which is laminated with an inert resin film and is excellent in plugging properties, liquid-tightness, and slidability. The gasket laminated with an inert resin film has multiple circular ribs that are to be in sliding contact with an inner wall of a syringe barrel, wherein the circular ribs include a front circular rib having a sliding contact portion whose cross section has a diameter that expands substantially linearly toward a back end of the syringe barrel, the linear portion has a length of 10 to 55% of the length of a sliding side face of the gasket, and the diameter of the linear portion which expands substantially linearly toward a back end of the syringe barrel has a diameter expansion ratio X between a minimum diameter r (mm) and a maximum diameter R (mm) of 0.1 to 8.0%.

Abstract: The present invention aims at providing a composite of a surface-modified fluororesin film and a thermoplastic resin bonded to each other, and medical equipment containing the composite. A method for producing a fluororesin/thermoplastic resin composite includes roughening a surface of a fluororesin film by ion beam irradiation from an ion source, and pressure-bonding the surface-modified fluororesin film obtained in the surface roughening step and a thermoplastic resin while maintaining the thermoplastic resin in a fluid state.

Abstract: The present invention aims to provide a gasket for a pre-filled syringe which has excellent air-tightness and liquid-tightness and a mold for forming the gasket. The present invention relate to a mold for a gasket laminated with an inactive film for a pre-filled syringe, wherein at least a surface of the mold which forms a seal sliding surface of an annular protrusion of the gasket is mirror finished to have an arithmetic mean roughness Ra of less than 0.03 ?m.

Abstract: There are provided a method for manufacturing a surface-modified fluororesin film capable of long-term inventory storage, a method for manufacturing a rubber composite composed of the surface-modified fluororesin film and rubber bonded together, and a rubber product for medical use made of the rubber composite. The method for manufacturing a surface-modified fluororesin film comprises the step of performing surface roughening on a fluororesin film RF by applying an ion beam from an anode layer ion source to the surface of the fluororesin film RF. A rubber is placed over the roughened surface of the thusly produced surface-modified fluororesin film, and, through vulcanization molding process, the surface-modified fluororesin film and the tuber can be firmly bonded to each other.

Abstract: Disclosed is a closure device for a container, which seals an opening (6) that opens at the top of a container (2) and has a rim (7) on its periphery. The closure device comprises a seal member (8) that is to cover the opening (6) on the top of the container (2), and a synthetic resin cap (9) that is to press the seal member (8) against the upper surface of the rim (7). The seal member (8) comprises a flange (10) to be mounted on the upper surface of the rim (7). The cap (9) comprises a top wall (15), a cylinder part (16), and a locking part (18). The top wall (15) is to be disposed above the flange (10). The cylinder part (16) hangs down from the outer circumference of the top wall (15). The locking part (18) is disposed on the inner surface of the cylinder part (16). After the cap (9) is pushed down, the locking part (18) locks at the under surface of the rim (7). The upper surface of the flange (10) has a compressible projection (29).