Patents by Inventor Eike Moller
Eike Moller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4056533Abstract: 1-Substituted pyrazole-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen or amino;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky;X isA. ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R.sup.2 via an oxygen or sulphur atom;B. propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N.sup.1 atom of the pyrazol ring via its methylene moiety; orC. methylene;Provided that when X is methylene, R.sup.1 is not hydrogen if R is amino;R.sup.2 is aryl unsubstituted or substituted by:A.Type: GrantFiled: November 14, 1975Date of Patent: November 1, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4053621Abstract: 1-[2-(.beta.-Naphthyloxy)ethyl]-3-methylpyrazolone-(5) and its salts are useful in the treatment and prophylaxis of thrombotic conditions. The compound is prepared through the reaction of 2-(.beta.-naphthyloxy)ethylhydrazine with either an acetoacetate or an ester of tetrolic acid, or through the condensation of 3-methylpyrazolinone-(5) with a derivative of 2-(.beta.-naphthyloxy)ethane, optionally with subsequent salt formation.Type: GrantFiled: June 2, 1975Date of Patent: October 11, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, deceased, Harald Horstmann, Friedel Seuter, Egbert Wehinger
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Patent number: 4045571Abstract: Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, lower alkyl or amino;X is methylene, ethylene, methylene wherein 1 hydrogen atom is substituted by lower alkyl, or ethylene wherein 1 hydrogen atom is substituted by lower alkyl or 1 hydrogen atom on each of the two carbon atoms is substituted by lower alkyl;Y is a direct bond, oxygen or sulphur, provided that when X is methylene wherein 1 hydrogen atom is substituted by alkyl of 1 to 4 carbon atoms, Y is a direct bond; Z is aryl of 6 to 10 carbon atoms unsubstituted or substituted by:A.Type: GrantFiled: November 20, 1975Date of Patent: August 30, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4032646Abstract: Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, lower alkyl or amino;R.sup.1 is lower alkyl, alkenyl of 2 to 4 carbon atoms, monoaryl or monoaralkyl unsubstituted or substituted in the aryl moiety by 1 or 2 of the same or different substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkoxy, lower alkenoxy, halogen, nitro, cyano and trifluoromethyl;X is methylene, ethylene, methylene wherein 1 hydrogen atom is substituted by lower alkyl, or ethylene wherein 1 hydrogen atom is substituted by lower alkyl or 1 hydrogen atom on each of the two carbon atoms is substituted by lower alkyl;Y is a direct bond, oxygen or sulphur, provided that when X is methylene, Y is a direct bond; andZ is aryl unsubstituted or nuclear substituted by:A. 3 halogens;B.Type: GrantFiled: September 4, 1975Date of Patent: June 28, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4018890Abstract: Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##SPC1##Or a pharmaceutically acceptable nontoxic salt thereofWhereinR is hydrogen, lower alkyl or amino;X is methylene, ethylene, methylene wherein 1 hydrogen atom is substituted by lower alkyl, or ethylene wherein 1 hydrogen atom is substituted by lower alkyl or 1 hydrogen atom on each of the two carbon atoms is substituted by lower alkyl;Y is a direct bond, oxygen or sulphur, provided that when X is methylene wherein 1 hydrogen atom is substituted by alkyl of 1 to 4 carbon atoms, Y is a direct bond;Z is aryl of 6 to 10 carbon atoms unsubstituted or substituted by:A. 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkenyl or 2 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, and alkenoxy of 2 to 4 carbon atoms;B.Type: GrantFiled: April 9, 1974Date of Patent: April 19, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4005215Abstract: 1-Substituted pyrazol-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen, amino, alkyl, alkenyl, phenyl or trifluoromethyl;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is alkyl; andR.sup.3 is pyridyl, or aryl substituted by:A. 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkenyl and lower alkoxy;B. cycloalkyl of 5, 6 or 7 carbon atoms or cycloalkenyl of 5, 6 or 7 carbon atoms;C. mono(lower alkyl)amino, di(lower alkyl)amino, trifluoromethoxy, nitro, cyano, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl, sulphamyl, lower alkylsulphamyl, di(lower alkyl)sulphamyl, or --SO.sub.n lower alkyl wherein n is 0, 1 or 2;D.Type: GrantFiled: January 14, 1975Date of Patent: January 25, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4002641Abstract: Pyrazole derivatives of the formula: ##STR1## and pharmaceutically acceptable nontoxic salts thereof WHEREINR is hydrogen, trifluoromethyl or alkyl;R.sup.1 is hydrogen or alkyl;R.sup.2 is alkyl;R.sup.3 is aryl substituted by:A. one or two of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl, alkenyl and alkoxy;B. one substituent selected from the group consisting of alkylamino, dialkylamino wherein the alkyl moieties may form a heterocyclic ring with the nitrogen atom to which they are attached, cycloalkyl, cycloalkenyl, trifluoromethoxy, nitro, cyano, carbonamido unsubstituted or substituted by 1 or 2 alkyl moieties, sulphonamido unsubstituted or substituted by 1 or 2 alkyl moieties, and SO.sub.n -alkyl wherein n is 0, 1 or 2;C.Type: GrantFiled: December 13, 1974Date of Patent: January 11, 1977Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 4000294Abstract: 1-Substituted pyrazole-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen or amino;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky;X isA. ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R.sup.2 via an oxygen or sulphur atom;B. propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N.sup.1 atom of the pyrazol ring via its methylene moiety; orC. methylene;Provided that when X is methylene, R.sup.1 is not hydrogen if R is amino;R.sup.2 is aryl unsubstituted or substituted by:A.Type: GrantFiled: November 14, 1975Date of Patent: December 28, 1976Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 3992404Abstract: 1-Substituted pyrazole-5-ones of the formula ##SPC1##And pharmaceutically acceptable, nontoxic salts thereof, whereinR is hydrogen or amino;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky;X isA. ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R.sup.2 via an oxygen or sulphur atom;B. propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N.sup.1 atom of the pyrazol ring via its methylene moiety; orC. methylene;Provided that when X is methylene, R.sup.1 is not hydrogen if R is amino;R.sup.2 is aryl unsubstituted or substituted by:A.Type: GrantFiled: May 19, 1975Date of Patent: November 16, 1976Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 3978077Abstract: 1-Substituted pyrazol-5-ones of the formula ##SPC1##And pharmaceutically acceptable, nontoxic salts thereof, whereinR is hydrogen, amino, alkyl, alkenyl, phenyl or trifluoromethyl;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is alkyl; andR.sup.3 is pyridyl, or aryl substituted by:A. 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkenyl and lower alkoxy;B. cycloalkyl of 5, 6, or 7 carbon atoms or cycloalkenyl of 5, 6 or 7 carbon atoms;C. mono(lower alkyl)amino, di(lower alkyl)amino, trifluoromethoxy, nitro, cyano, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl, sulphamyl, lower alkylsulphamyl, di(lower alkyl)sulphamyl, or --SO.sub.n lower alkyl wherein n is 0, 1 or 2;D.Type: GrantFiled: May 22, 1975Date of Patent: August 31, 1976Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 3957814Abstract: 1-Substituted pyrazol-5-ones of the formula ##SPC1##And pharmaceutically acceptable, nontoxic salts thereof, whereinR is hydrogen, amino, alkyl, alkenyl, phenyl or trifluoromethyl;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl;R.sup.2 is alkyl; andR.sup.3 is pyridyl, or aryl substituted by:A. 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkenyl and lower alkoxy;B. cycloalkyl of 5, 6 or 7 carbon atoms or cycloalkenyl of 5, 6 or 7 carbon atoms;C. mono(lower alkyl)amino, di(lower alkyl)amino, trifluoromethoxy, nitro, cyano, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl, sulphamyl, lower alkylsulphamyl, di(lower alkyl)sulphamyl, or --SO.sub.n lower alkyl wherein n is 0, 1 or 2;D.Type: GrantFiled: April 15, 1974Date of Patent: May 18, 1976Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 3952008Abstract: 1-Substituted pyrazole-5-ones of the formula ##SPC1##And pharmaceutically acceptable, nontoxic salts thereof,WhereinR is hydrogen or amino;R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky;X isA. ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R.sup.2 via an oxygen or sulphur atom;B. propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N.sup.1 atom of the pyrazol ring via its methylene moiety; orC. methylene; provided that when X is methylene, R.sup.1 is not hydrogen if R is amino;R.sup.2 is aryl unsubstituted or substituted by:A.Type: GrantFiled: April 15, 1974Date of Patent: April 20, 1976Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
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Patent number: 3949083Abstract: Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##SPC1##Or a pharmaceutically acceptable nontoxic salt thereof whereinR is hydrogen, lower alkyl or amino;R.sup.1 is lower alkyl, alkenyl of 2 to 4 carbon atoms, monoaryl or monoaralkyl unsubstituted or substituted in the aryl moiety by 1 or 2 of the same or different substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkoxy, lower alkenoxy, halogen, nitro, cyano and trifluoromethyl;X is methylene, ethylene, methylene wherein 1 hydrogen atom is substituted by lower alkyl, or ethylene wherein 1 hydrogen atom is substituted by lower alkyl or 1 hydrogen atom on each of the two carbon atoms is substituted by lower alkyl;Y is a direct bond, oxygen or sulphur, provided that when X is methylene, Y is a direct bond; andZ is aryl unsubstituted or nuclear substituted by:A. 3 halogens;B.Type: GrantFiled: April 9, 1974Date of Patent: April 6, 1976Assignee: Bayer AktiengesellschaftInventors: Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann