Abstract: The present invention is directed towards the holding of medical devices during manufacture to enable the application of therapeutic and/or protective coatings. More specifically, the present invention provides medical device holders that securely retain stents and other medical devices during the application of a coating while minimizing compressive and tensile forces applied to the stents. The invention avoids disruptions to coating quality due to holder blockage during coating deposition. The invention discloses an improved device containing a mandrel and frame that may improve coating uniformity by eliminating shadowing from the frame of the medical device holder when applying coatings to stents and other medical devices.

Abstract: Method and device for the creation of vaccines using ultrasonic waves, comprised of an ultrasound generator and a transducer to produce ultrasonic waves, is disclosed. The transducer has a specific ultrasound tip depending upon the type of delivery method utilized and depending on the shape of the vial containing the solution of the virus, bacterium, or other infectious agent. The apparatus delivers ultrasonic waves to solution either directly through the insertion of the ultrasound tip into the solution, through a coupling medium adjacent to the vial or near the vial, or through an air or gas medium. The ultrasound waves have the effect of destroying the viable virus, bacterium, or other infectious agent and of releasing the appropriate antigens, thus resulting in a vaccine for that virus, bacterium, or other infectious agent.

Abstract: Ultrasound methods and apparatus for mixing two or more different liquids are disclosed. The ultrasound methods and apparatus may mix varied components including drugs, polymers, and coatings for application to a variety of medical apparatus surfaces. The apparatus and technique can generate a proper mixture which is uninterruptedly/continuously delivered to the surface of the medical apparatus. The apparatus may include specific ultrasound transducer/tip configurations which may allow for the mixing of different liquids in a mixing camera located inside of the vibrating tip. The apparatus and methods of the present invention may mix different drugs, applying them to stent surface using different effects like ultrasound cavitation and radiation forces. Furthermore, the disclosed methods and apparatus may generate a mixture and may deliver a targeted, gentle, highly controllable dispensation of continuous liquid spray which can reduce the loss of expensive pharmaceuticals.

Abstract: An ultrasonic apparatus and method is provided for the selective and targeted removal of unwanted tissues. The apparatus and methods may utilize combinations of ultrasonic and cryogenic energy for the selective removal tissue. The apparatus generates and delivers to the tissue cryogenic and ultrasonic energy either in combination or in sequence, provides resize ablation of unwanted tissue parts, and may be used on various body tissues including internal organs.

Abstract: The present invention is directed towards the holding of medical devices during manufacture to enable the application of therapeutic and/or protective coatings. More specifically, the present invention provides medical device holders that securely retain stents and other medical devices during the application of a coating while minimizing compressive and tensile forces applied to the stents. The invention avoids disruptions to coating quality due to holder blockage during coating deposition. The invention discloses an improved device containing a mandrel and frame that may improve coating uniformity by eliminating shadowing from the frame of the medical device holder when applying coatings to stents and other medical devices.

Abstract: The present invention is directed towards the holding of medical devices during manufacture to enable the application of therapeutic and/or protective coatings. More specifically, the present invention provides medical device holders that securely retain stents and other medical devices during the application of a coating while minimizing compressive and tensile forces applied to the stents. The invention avoids disruptions to coating quality due to holder blockage during coating deposition. The invention discloses an improved device containing a mandrel and frame that may improve coating uniformity by eliminating shadowing from the frame of the medical device holder when applying coatings to stents and other medical devices.

Abstract: The present invention relates to a method of treating wounds by applying ultrasonic energy to a wound to inactivate, destroy, and/or remove infectious agents, and/or deliver a coupling medium to debride, cleanse, and/or sterilize the wound. The device of the present invention comprises an ultrasound generator, an ultrasound transducer, a transducer tip at the distal end of the ultrasound transducer, and a radiation surface tilted with respect to the longitudinal axis of the transducer tip. Ultrasonic waves emanating from the tilted radiation surface of the present invention may travel through the air directly to the wound, and/or may be applied to the wound through a coupling medium.

Abstract: The present invention relates to a method of treating wounds by applying ultrasonic energy to a wound to inactivate, destroy, and/or remove infectious agents, and/or deliver a coupling medium to debride, cleanse, and/or sterilize the wound. The method of the present invention comprises the steps of placing the wound in front of the ultrasound emitting surface in near field, activating the ultrasound transducer, generating ultrasonic energy, emitting ultrasonic waves from ultrasound emitting surface, allowing ozone to be created in the near field, applying ozone to the wound, introducing a coupling medium to the ultrasound emitting surface of the wound device, sonicating the coupling medium, and applying the coupling medium to a wound.