Abstract: An applicator assembly for use with a dmg infusion system having multiple wear configurations, including a tethered configuration and a patch configuration. The applicator assembly may be a multi-functional device configured to (1) selectively apply an infusion head and/or a holder to a patients skin and (2) insert an injection device of the infusion head into the patients skin. The drug infusion system may be worn interchangeably in the tethered configuration by placing a dmg delivery device in fluid communication with the infusion head via an intermediate tubing set, or in the patch configuration by coupling the drug delivery device to the holder and placing the dmg delivery device in fluid communication with the infusion head without the intermediate tubing set.