Abstract: A method includes receiving measurement information from a hydrocarbon fluid production network where the measurement information includes pressure data and fluid flow data; receiving simulated information from a model-based framework for the hydrocarbon fluid production network that includes boundary conditions based at least in part on at least a portion of the measurement information; comparing the measurement information and the simulated information to detect a fluid leak in the hydrocarbon fluid production network; determining a location of the fluid leak in the hydrocarbon fluid production network; and outputting the location of the fluid leak in the hydrocarbon fluid production network.