Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: An Al-based bearing alloy and a slide bearing incorporating the alloy exhibit high corrosion resistance and maintain high strength for a long period of time even in a high temperature environment. The Al-based bearing alloy and slide bearing includes an Al matrix, and acicular compounds which are needle-shaped that precipitate at a plurality of sites in a structure of the Al matrix, and that have a minor diameter and a major diameter.

Abstract: An Al-based bearing alloy and a slide bearing incorporating the alloy exhibit high corrosion resistance and maintain high strength for a long period of time even in a high temperature environment. The Al-based bearing alloy and slide bearing includes an Al matrix, and acicular compounds which are needle-shaped that precipitate at a plurality of sites in a structure of the Al matrix, and that have a minor diameter and a major diameter.

Abstract: A plain bearing is provided which has an Sn-and-Si-rich layer formed of an Al alloy containing Sn and Si, and a base material which does not contain Sn. The Sn-and-Si-rich layer have the sliding surface having an area ratio of Sn phase grains in a range of 6 to 40% and that of Si phase grains in a range of 5 to 25%.

Abstract: A plain bearing is provided which has an Sn-and-Si-rich layer formed of an Al alloy containing Sn and Si, and a base material which does not contain Sn. The Sn-and-Si-rich layer have the sliding surface having an area ratio of Sn phase grains in a range of 6 to 40% and that of Si phase grains in a range of 5 to 25%.

Abstract: A method of manufacturing a multilayer material including a back metal and a metal plate made from a metal differing from the back metal is disclosed. The method includes heating powder of the metal formed into the metal plate in a reducing atmosphere so that an oxide on a surface of the metal powder is deoxidized, and spreading the deoxidized metal powder onto the back metal and irradiating laser beam having an energy density of 10 to 100 kW/cm2 onto the metal powder spread on the back metal so that the metal powder is partially heated to be melted, while the laser beam is moved relative to the spread metal powder, and quenching the melted part of the metal powder at an underside of the back metal so that the melted part is rapidly solidified, whereupon the multilayer material has a dendritic structure in which the metal plate extends substantially vertically from a surface of the back metal, and the dendritic structure has a crystal grain size equal to or smaller than 0.

Abstract: A copper base alloy suitable for use as a material for a sliding member used under severe sliding conditions such as a floating bush bearing of a turbocharger used in automobiles is disclosed. The alloy comprises, by mass %, 15 to 25% Zn, 4.2 to 10% Di, 2 to 7% Mn, 1 to 3% Si and balance of Cu and unavoidable impurities, the alloy having a structure of which matrix is composed of ?-single phase, wherein a eutectic structure of the ?-phase and an Mn—Si compound and Bi particle are distributed throughout the matrix.

Abstract: A plain bearing is provided which has an Sn-and-Si-rich layer formed of an Al alloy containing Sn and Si, and a base material which does not contain Sn. The Sn-and-Si-rich layer have the sliding surface having an area ratio of Sn phase grains in a range of 6 to 40% and that of Si phase grains in a range of 5 to 25%.

Abstract: There are provided a copper-based sintered sliding material comprising a steel back metal layer, and a sintered layer made of Cu or a Cu-based alloy which is bonded onto the steel back metal layer, the steel back metal layer having a hardness not less than 160 Hv and an elongation not less than 10%, the sintered layer having a hardness not more than 130 Hv and crystal grains each provided with a grain size not more than 45 &mgr;m, a method of producing the sliding material, and a sliding bearing formed of the sliding material.

Abstract: A copper base alloy suitable for use as a material for a sliding member used under severe sliding conditions such as a floating bush bearing of a turbocharger used in automobiles is disclosed. The alloy consists of, by mass %, 15 to 25% Zn, 4.2 to 10% Bi, 2 to 7% Mn, 1 to 3% Si and balance of Cu and unavoidable impurities, the alloy having a structure of which matrix is composed of &agr;-single phase, wherein a eutectic structure of the &agr;-phase and an Mn—Si compound and Bi particle are distributed throughout the matrix.

Abstract: A multilayer material comprising a backing material (10) and a obverse material (12) made of a metal different from the backing material, said obverse material being bonded to the backing material, said obverse material having a rapidly cooled dendrite structure extended substantially vertically to the backing material, said dendrite structure having a grain size not more than 0.02 mm in a cutting plane in parallel to the backing material and/or a dendrite arm spacing not more than 0.02 mm in a cutting plane vertical to the backing material.

Abstract: A method of manufacturing a multilayer material including a back metal and a metal plate made from a metal differing from the back metal is disclosed. The method includes heating powder of the metal formed into the metal plate in a reducing atmosphere so that an oxide on a surface of the metal powder is deoxidized, and spreading the deoxidized metal powder onto the back metal and irradiating laser beam having an energy density of 10 to 100 kW/cm2 onto the metal powder spread on the back metal so that the metal powder is partially heated to be melted, while the laser beam is moved relative to the spread metal powder, and quenching the melted part of the metal powder at an underside of the back metal so that the melted part is rapidly solidified, whereupon the multilayer material has a dendritic structure in which the metal plate extends substantially vertically from a surface of the back metal, and the dendritic structure has a crystal grain size equal to or smaller than 0.

Abstract: Disclosed is a composite sliding material having a steel plate and a sintered copper alloy layer which is bonded to the steel plate. The copper alloy contains, 1.5 to 15 mass % Sn, 1.5 to 15 mass % Bi, 1.5 to 20 volume % of a solid lubricant, and balance of Cu and incidental impurities. The volume ratio of Bi to the solid lubricant is in a range of 0.5 to 2.0. Bi and the solid lubricant improves the copper alloy in sintering property, since Bi melts when sintering because of a low melting point resulting in improved sintering property, and the solid lubricant ensures good anti-seizure property, and deterioration of mechanical strength is prevented by virtue of a phenomenon that the solid lubricant is entrained in Bi.

Abstract: A multilayer material comprising a backing material (10) and a obverse material (12) made of a metal different from the backing material, said obverse material being bonded to the backing material, said obverse material having a rapidly cooled dendrite structure extended substantially vertically to the backing material, said dendrite structure having a grain size not more than 0.02 mm in a cutting plane in parallel to the backing material and/or a dendrite arm spacing not more than 0.02 mm in a cutting plane vertical to the backing material.

Abstract: There are provided a copper-based sintered sliding material comprising a steel back metal layer, and a sintered layer made of Cu or a Cu-based alloy which is bonded onto the steel back metal layer, the steel back metal layer having a hardness not less than 160 Hv and an elongation not less than 10%, the sintered layer having a hardness not more than 130 Hv and crystal grains each provided with a grain size not more than 45 &mgr;m, a method of producing the sliding material, and a sliding bearing formed of the sliding material.

Abstract: Disclosed is a composite sliding material having a steel plate and a sintered copper alloy layer which is bonded to the steel plate. The copper alloy contains, 1.5 to 15 mass % Sn, 1.5 to 15 mass % Bi, 1.5 to 20 volume % of a solid lubricant, and balance of Cu and incidental impurities. The volume ratio of Bi to the solid lubricant is in a range of 0.5 to 2.0. Bi and the solid lubricant improves the copper alloy in sintering property, since Bi melts when sintering because of a low melting point resulting in improved sintering property, and the solid lubricant ensures good anti-seizure property, and deterioration of mechanical strength is prevented by virtue of a phenomenon that the solid lubricant is entrained in Bi.