Patents by Inventor Eisaku Tsujii

Eisaku Tsujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic peptide compounds
    Patent number: 8252895
    Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: August 28, 2012
    Assignee: Astellas Pharma Inc.
    Inventors: Masahiro Neya, Seiji Yoshimura, Kazunori Kamijyo, Takuya Makino, Minoru Yasuda, Toshio Yamanaka, Eisaku Tsujii, Yukiko Yamagishi
  • Cyclic peptide compounds
    Patent number: 7872097
    Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: January 18, 2011
    Assignee: Astellas Pharma Inc.
    Inventors: Masahiro Neya, Seiji Yoshimura, Kazunori Kamijyo, Takuya Makino, Minoru Yasuda, Toshio Yamanaka, Eisaku Tsujii, Yukiko Yamagishi
  • NEW CYCLIC PEPTIDE COMPOUNDS
    Publication number: 20100286033
    Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
    Type: Application
    Filed: July 21, 2010
    Publication date: November 11, 2010
    Inventors: Masahiro NEYA, Seiji Yoshimura, Kazunori Kamijyo, Takuya Makino, Minoru Yasuda, Toshio Yamanaka, Eisaku Tsujii, Yukiko Yamagishi
  • Cyclic Peptide Compounds
    Publication number: 20090170755
    Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
    Type: Application
    Filed: October 26, 2006
    Publication date: July 2, 2009
    Inventors: Masahiro Neya, Seiji Yoshimura, Kazunori Kamijyo, Takuya Makino, Minoru Yasuda, Toshio Yamanaka, Eisaku Tsujii, Yukiko Yamagishi
  • Antimicrobial agent, FR109615 and production thereof
    Patent number: 5514715
    Abstract: A method of killing pathogenic fungi by contacting them with an effective amount of (1R,2S)-2-aminocyclopentanecarboxylic acid (FR109615) or a salt thereof.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: May 7, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara
  • WS7622A mono- or di-sulfate, process for preparation thereof and use thereof
    Patent number: 5364624
    Abstract: A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: November 15, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • WS7622A mono- or di- sulfate, process for preparation thereof and use thereof
    Patent number: 5292510
    Abstract: WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: March 8, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis
    Patent number: 5279826
    Abstract: A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: January 18, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Noriaki Inamura, Yasuhiko Shinguh, Kunio Nakahara, Yoshitada Notsu, Masanori Okamoto, Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Nobuharu Shigematsu, Masakuni Okuhara
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome
    Patent number: 5167958
    Abstract: A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: December 1, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • Pharmaceutically useful 5-hydroxy-2,3-dihydro-benzofurans and 5-hydroxy-benzofurans
    Patent number: 5043354
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each lower alkyl, R.sup.4 is hydrogen or hydroxy, and a heavy solid line means a double bond when R.sup.4 is hydrogen and a single bond when R.sup.4 is hydroxy is useful in the treatment of diseases caused by reactive oxygen species and organic radicals.
    Type: Grant
    Filed: May 3, 1990
    Date of Patent: August 27, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Eisaku Tsujii, Yasuhisa Tsurumi, Masanori Okamoto, Masakuni Okuhara, Teruo Oku, Masashi Hashimoto
  • Antimicrobial agent, FR109615 and production thereof
    Patent number: 5037809
    Abstract: (1R, 2S)-2-Aminocyclopentanecarboxylic acid and its salts useful as antimicrobial agents.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: August 6, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use thereof
    Patent number: 5021240
    Abstract: The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.
    Type: Grant
    Filed: February 21, 1990
    Date of Patent: June 4, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • Compound, WF11605 and derivative thereof
    Patent number: 4963585
    Abstract: The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl,R.sup.2 is hydrogen or ##STR2## in which R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen or lower alkanoyl,R.sup.3 is carboxy or a protected carboxy, and pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 14, 1989
    Date of Patent: October 16, 1990
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Masanori Okamoto, Eisaku Tsujii, Tsutomu Kaizu, Hiroshi Hatanaka, Masakuni Okuhara, Kozo Sawada, Hirokazu Tanaka