Abstract: Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

Abstract: Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

Abstract: Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

Abstract: Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

Abstract: An artificial lung is provided that includes a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I): wherein in Formula (I), R3 represents a hydrogen atom or a methyl group, R1 represents an alkylene group having 1 to 4 carbon atoms, and R2 represents an alkyl group having 1 to 4 carbon atoms.

Abstract: Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

Abstract: A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter ?d1 of the hollow fiber membrane 31 is equal to or smaller than 150 ?m, a tilt angle ? with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60°, and a ratio ?D1/L of an outer diameter ?D1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.

Abstract: An artificial lung 100 has a filling portion 110 that communicates with an inlet port 101 and an outlet port 102 for blood and is filled with blood, a heat exchange portion 160 that includes a bundle of a plurality of hollow fibers 163 for heat exchange and is provided inside the filling portion, a gas exchange portion 170 that includes a bundle of a plurality of hollow fibers 173 for gas exchange and is provided inside the filling portion to be adjacent to the heat exchange portion, and a porous member 180 that is disposed in a gap 190 between the heat exchange portion and the gas exchange portion. A volume within the housing occupied by a wall of the porous member correspondingly reduces a priming volume within the housing available for conveying the blood (i.e., a bulk volume of the porous member partially blocks or fills the gap.

Abstract: An artificial lung is provided that includes a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I): wherein in Formula (I), R3 represents a hydrogen atom or a methyl group, R1 represents an alkylene group having 1 to 4 carbon atoms, and R2 represents an alkyl group having 1 to 4 carbon atoms.

Abstract: A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.

Abstract: An Oxygenator as a medical instrument includes at least one first hollow fiber membrane layer comprised of a plurality of integrated first hollow fiber membranes, and forms a shape of a cylindrical body as a whole, and at least one second hollow fiber membrane layer disposed at the outer circumferential side of the first hollow fiber membrane layer in a state of being concentric with the first hollow fiber membrane layer, has a plurality of integrated second hollow fiber membranes, and forms a shape of a cylindrical body as a whole. Moreover, each of the first hollow fiber membranes is wound around a central axis, and each of the second hollow fiber membranes is wound around a central axis. The number of times the second hollow fiber membranes are wound is smaller than the number of times the first hollow fiber membranes are wound.

Abstract: A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.

Abstract: An artificial lung has a gas exchanger portion with an external circulation-type gas exchanging hollow fiber membrane bundle and a heat exchanger portion with a heat exchanging element. Various design parameters of the gas exchanger and heat exchanger portions are configured to obtain a predetermined performance factor. In one embodiment, the design parameters are adjusted so that when a heat exchange performance coefficient of the artificial lung, a blood filling amount of the artificial lung, and a blood side pressure loss of the artificial lung are measured, they result in a performance factor equal to or greater than 1.5, wherein the performance factor is defined as heat exchange performance coefficient/(blood filling amount×blood side pressure loss).

Abstract: An artificial lung has a gas exchanger portion with an external circulation-type gas exchanging hollow fiber membrane bundle and a heat exchanger portion with a heat exchanging element. Various design parameters of the gas exchanger and heat exchanger portions are configured to obtain a predetermined performance factor. in one embodiment, the design parameters are adjusted so that when a gas exchange performance, a heat exchange performance coefficient, a blood filling amount, and a blood side pressure loss are measured, they result in a performance factor between 1.5 and 2.5, wherein the performance factor is defined as (gas exchange performance×heat exchange performance coefficient)/(blood filling amount×blood side pressure loss).

Abstract: A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter ?d1 of the hollow fiber membrane 31 is equal to or smaller than 150 ?m, a tilt angle ? with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60°, and a ratio ?D1/L of an outer diameter ?D1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.

Abstract: A bias magnetic flux is formed so as to be passed through the electromagnet core of an electromagnet, and a bypass magnetic path, serving as a magnetic path for a control magnetic flux, is formed in parallel with a permanent magnet, the bypass magnetic path being magnetized in a direction in which passage of the bias magnetic flux is blocked, and thus, even if the permanent magnet and the electromagnet are disposed in locations where the mutual magnetic fluxes of the permanent magnet and the electromagnet are superimposed, the control magnetic flux formed by the electromagnet is passed through the bypass magnetic path, whereby loss of the control magnetic flux can be suppressed. Thereby, the permanent magnet and the electromagnet can be disposed in locations where the mutual magnetic fluxes are superimposed, whereby the device can be made smaller in size.

Abstract: An Oxygenator as a medical instrument includes at least one first hollow fiber membrane layer comprised of a plurality of integrated first hollow fiber membranes, and forms a shape of a cylindrical body as a whole, and at least one second hollow fiber membrane layer disposed at the outer circumferential side of the first hollow fiber membrane layer in a state of being concentric with the first hollow fiber membrane layer, has a plurality of integrated second hollow fiber membranes, and forms a shape of a cylindrical body as a whole. Moreover, each of the first hollow fiber membranes is wound around a central axis, and each of the second hollow fiber membranes is wound around a central axis. The number of times the second hollow fiber membranes are wound is smaller than the number of times the first hollow fiber membranes are wound.

Abstract: A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.

Abstract: A heart pump including first and second cavities, each cavity including a respective inlet and outlet, a connecting tube extending between the first and second cavities, an impeller including: a first set of vanes mounted on a first rotor in the first cavity portion; a second set of vanes mounted on a second rotor in the second cavity portion; and, a shaft connecting the first and second rotors, the shaft extending through the connecting tube, a drive for rotating the impeller and a magnetic bearing including at least one bearing coil for controlling an axial position of the impeller, at least one of the drive and magnetic bearing being mounted outwardly of the connecting tube, at least partially between the first and second cavity portions.