Patents by Inventor Eitan Fibach

Eitan Fibach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 8202724
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: June 19, 2012
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells
    Publication number: 20110045589
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: October 6, 2010
    Publication date: February 24, 2011
    Applicants: Gamida Cell LTD., Hadasit Medical Research Services And Development LTD.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7855075
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: December 21, 2010
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20090004158
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: May 19, 2008
    Publication date: January 1, 2009
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7429489
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: September 30, 2008
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7312078
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: December 25, 2007
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development, Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7169605
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: January 30, 2007
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 6962698
    Abstract: A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing cooper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: November 8, 2005
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development, Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20050214262
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Application
    Filed: March 18, 2005
    Publication date: September 29, 2005
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20050118150
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: October 14, 2004
    Publication date: June 2, 2005
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 6887704
    Abstract: A cell population cultured ex-vivo in a culture medium under conditions permitting cells of the cell population to proliferate and, at the same time, reducing a capacity of the cells in utilizing cooper, the cells are hence expanded yet not further differentiated as compared to ex-vivo seeded cells from which the cell population developed.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: May 3, 2005
    Assignee: Gamida Cell Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20050031595
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: March 4, 2003
    Publication date: February 10, 2005
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Serum-derived factor inducing cell differentiation and medical uses thereof
    Patent number: 6783775
    Abstract: The present invention relates to a biologically active serum-derived composition of matter (SDF), having a low molecular weight, being electrically charged at acidic pH and having absorption at 280 nm. The molecular weight of said SDF was determined by electron spray mass spectrometry and is of 316 Da. SDF of the present invention or its complex with ceruloplasmin (CP) have several therapeutic properties. For example, SDF or its complex with CP is capable of inducing terminal cell differentiation of leukemic cells, which as a result, may lose their ability to proliferate and their ability for self cell renewal. Further, SDF or the complex with CP is capable of stimulating the proliferation of early, normal progenitor cells and inhibiting enhanced angiogenesis. In addition, SDF or its complex with CP is capable of ex vivo expanding normal stem and progenitor cells.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: August 31, 2004
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Eliezer A. Rachmilewitz
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20020159981
    Abstract: A cell population cultured ex-vivo in a culture medium under conditions permitting cells of the cell population to proliferate and, at the same time, reducing a capacity of the cells in utilizing cooper, the cells are hence expanded yet not further differentiated as compared to ex-vivo seeded cells from which the cell population developed.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 31, 2002
    Applicant: Gamida-Cell Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20020114789
    Abstract: A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing copper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.
    Type: Application
    Filed: November 19, 2001
    Publication date: August 22, 2002
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Serum-derived factor inducing cell differentiation and medical uses thereof
    Publication number: 20020054916
    Abstract: The present invention relates to a biologically active serum-derived composition of matter (SDF), having a low molecular weight, being electrically charged at acidic pH and having absorption at 280 nm. The molecular weight of said SDF was determined by electron spray mass spectrometry and is of 316 Da. SDF of the present invention or its complex with ceruloplasmin (CP) have several therapeutic properties. For example, SDF or its complex with CP is capable of inducing terminal cell differentiation of leukemic cells, which as a result, may lose their ability to proliferate and their ability for self cell renewal. Further, SDF or the complex with CP is capable of stimulating the proliferation of early, normal progenitor cells and inhibiting enhanced angiogenesis. In addition, SDF or its complex with CP is capable of ex vivo expanding normal stem and progenitor cells.
    Type: Application
    Filed: November 9, 2001
    Publication date: May 9, 2002
    Inventors: Tony Peled, Eitan Fibach, Eliezer A. Rachmilewitz
  • Serum-derived factor inducing cell differentiation and medical uses thereof
    Patent number: 6372262
    Abstract: The present invention relates to a biologically active serum-derived composition of matter (SDF), having a low molecular weight, being electrically charged at acidic pH and having absorption at 280 nm. The molecular weight of said SDF was determined by electron spray mass spectrometry and is of 316 Da. SDF of the present invention or its complex with ceruloplasmin (CP) have several therapeutic properties. For example, SDF or its complex with CP is capable of inducing terminal cell differentiation of leukemic cells, which as a result, may lose their ability to proliferate and their ability for self cell renewal. Further, SDF or the complex with CP is capable of stimulating the proliferation of early, normal progenitor cells and inhibiting enhanced angiogenesis. In addition, SDF or its complex with CP is capable of ex vivo expanding normal stem and progenitor cells.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: April 16, 2002
    Assignee: Hadasit Medical Research Services & Development Company Ltd.
    Inventors: Tony Peled, Eitan Fibach, Eliezer A. Rachmilewitz