Abstract: Systems and methods for performing aspiration thrombectomy. The aspiration catheter assembly can include a support catheter and an aspiration catheter extending through the support catheter. The catheter assembly can include a distal valve apparatus that can control a level of vacuum at a distal end of the catheter system. Irrigation can flow between the support catheter and the aspiration catheter to flush the catheter assembly.

Abstract: Temporary pacing catheters for pacing a patient’s heart and methods of use. The pacing catheter may include variable stiffness shaft. A distal portion of the pacing catheter may carry one or more electrodes for pacing the patient’s heart. The pacing catheter may include a lumen configured to receive a shaping instrument. The pacing catheter may have a first configuration when advanced to the patient’s heart without the shaping instrument and a second configuration configured to stabilize the pacing catheter within the patient’s heart when the shaping instrument is introduced through the lumen.

Abstract: An angioplasty balloon having an elastic constraining structure that partially expands with the balloon so that, at maximum balloon inflation, the constraining structure forms a pattern of channels or “pillows” on the balloon.

Abstract: Systems and methods for performing aspiration thrombectomy. The aspiration catheter assembly can include a support catheter and an aspiration catheter extending through the support catheter. The catheter assembly can include a distal valve apparatus that can control a level of vacuum at a distal end of the catheter system. Irrigation can flow between the support catheter and the aspiration catheter to flush the catheter assembly.

Abstract: Angioplasty and other dilatation devices are provided with scoring elements which incorporate a drug to be delivered to a body lumen, typically a blood vessel. The scoring elements have drugs and other active substances coated over a portion thereof or incorporated within internal structure of the element so that the drug is released into the luminal wall closely associated diseased regions of the body lumen as the scoring structure is radially expanded into the wall.

Abstract: A system for performing angioplasty and a method of utilizing same are provided. The system includes a balloon mounted on a catheter shaft and an expandable constraining structure mounted over the balloon. The expandable constraining structure includes a plurality of axial struts crossing a plurality of radially-expandable rings being for constraining said balloon such that isolated balloon regions protrude through openings in said constraining structure when the balloon is inflated.

Abstract: A system for performing angioplasty and a method of utilizing same are provided. The system includes a balloon mounted on a catheter shaft and an expandable constraining structure mounted over the balloon. The expandable constraining structure includes a plurality of axial struts crossing a plurality of radially-expandable rings being for constraining said balloon such that isolated balloon regions protrude through openings in said constraining structure when the balloon is inflated.

Abstract: Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction.

Abstract: A balloon catheter and methods of using same are provided. The balloon catheter can include an expandable structure mounted over a balloon coated with a composition. The expandable structure includes a plurality of axial struts crossing a plurality of radially-expandable rings for constraining the balloon such that isolated balloon regions can protrude through openings in the expandable structure when the balloon is inflated. The balloon catheter can be configured to maximize scraping of the composition from the surface of the balloon by the struts of the expandable structure during balloon inflation.

Abstract: Methods and devices are used to treat a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction. For example, a clip may be advanced distally across the deep dorsal vein and an anchor on the clip deployed on a proximal side of the Tunica albuginea. The clip can then be pulled back and a distal anchor on the clip deployed to reduce a cross-sectional area of the deep dorsal vein and anchor the deep dorsal vein to the Tunica albuginea. Anchoring of the dorsal vein to the Tunica albuginea further reduces the cross-sectional area of the deep dorsal vein in response to expansion of the patient's corpora cavernosa.

Abstract: A system for dilating a stenosed vessel is provided. The system includes a balloon mounted on a catheter shaft, the balloon being composed of a first material and fibers forming a grid attached to a surface of the balloon or integrated within a wall thereof. The fibers are composed of a second material having less elasticity than the first material such that when the balloon is inflated beyond a predetermined pressure balloon regions protrude from the grid formed by the fibers.

Abstract: A balloon catheter and methods of using same are provided. The balloon catheter can include an expandable structure mounted over a balloon coated with a composition. The expandable structure includes a plurality of axial struts crossing a plurality of radially-expandable rings for constraining the balloon such that isolated balloon regions can protrude through openings in the expandable structure when the balloon is inflated. The balloon catheter can be configured to maximize scraping of the composition from the surface of the balloon by the struts of the expandable structure during balloon inflation.

Abstract: A liquid drug delivery formulation forms a foam when combined with a gas source. The formulation includes water, at least one hydrophilic solvent, at least one surfactant or foaming agent, and a drug particle which is a mixture of a therapeutic agent and an excipient. The formulations are useful for delivering foams to body cavities and lumens, such as the sinuses for treating sinusitis and other conditions.

Abstract: An angioplasty catheter has a catheter body having a balloon or other radially expandable shell at its distal end. A non-axial external structure is carried over the shell and scores a stenosed region in a blood vessel when the balloon is inflated therein. The catheter has an attachment structure disposed between the catheter body and the balloon to accommodate foreshortening and rotation of the external structure as the balloon is expanded. The external structure may be part of a helical cage structure which floats over the balloon.

Abstract: A device for controlling blood flow through a vein is provided. The device includes a device body configured for implantation in or around the vein. The device body is capable of reducing flow through the vein in response to an increase in tissue pressure around the vein.

Abstract: An angioplasty balloon having an elastic constraining structure that partially expands with the balloon so that, at maximum balloon inflation, the constraining structure forms a pattern of channels or “pillows” on the balloon.

Abstract: A constraining structure for use with a balloon catheter can include multiple longitudinal struts and multiple, sinusoidal shaped radial rings. The constraining structure can expand to form a pattern of channels including substantially square windows. The constraining structure can modify, restrict, and control a shape and/or size of the balloon when inflated. Inflating the balloon catheter within the constraining structure can provide nonuniform pressure on a vessel wall adjacent the balloon.

Abstract: An angioplasty balloon having an elastic constraining structure that partially expands with the balloon so that, at maximum balloon inflation, the constraining structure forms a pattern of channels or “pillows” on the balloon.

Abstract: A constraining structure for use with a balloon catheter can include multiple longitudinal struts and multiple, sinusoidal shaped radial rings. The constraining structure can expand to form a pattern of channels including substantially square windows. The constraining structure can modify, restrict, and control a shape and/or size of the balloon when inflated. Inflating the balloon catheter within the constraining structure can provide nonuniform pressure on a vessel wall adjacent the balloon.

Abstract: A device for controlling blood flow through a vein is provided. The device includes a device body configured for implantation in or around the vein. The device body is capable of reducing flow through the vein in response to an increase in tissue pressure around the vein.