Patents by Inventor Eitora Yamamura
Eitora Yamamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230042760Abstract: A prostaglandin production method according to the present invention comprises reacting an unsaturated fatty acid with cyclooxygenase in the presence of a reducing agent. According to the present invention, it is possible to produce prostaglandins at a high yield.Type: ApplicationFiled: December 25, 2020Publication date: February 9, 2023Applicant: KYOWA PHARMA CHEMICAL CO., LTD.Inventors: Eitora YAMAMURA, Jun OGAWA, Akinori ANDO
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Patent number: 10370670Abstract: The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than ½ of the weight average chain length of one ssRNA constituting the second chain.Type: GrantFiled: October 24, 2017Date of Patent: August 6, 2019Assignee: KYOWA HAKKO BIO CO., LTD.Inventors: Tetsuo Nakano, Eitora Yamamura
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Publication number: 20180044678Abstract: The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than ½ of the weight average chain length of one ssRNA constituting the second chain.Type: ApplicationFiled: October 24, 2017Publication date: February 15, 2018Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Tetsuo NAKANO, Eitora YAMAMURA
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Patent number: 9816095Abstract: The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than ½ of the weight average chain length of one ssRNA constituting the second chain.Type: GrantFiled: December 6, 2013Date of Patent: November 14, 2017Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Tetsuo Nakano, Eitora Yamamura
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Publication number: 20160215010Abstract: The present invention provides a method of recovering dsRNA, from which a surfactant and endotoxin have been removed simultaneously, which includes mixing the surfactant and dsRNA, and contacting the mixture with a hydrophobic adsorptive resin or activated carbon.Type: ApplicationFiled: October 2, 2014Publication date: July 28, 2016Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Tetsuo NAKANO, Eitora YAMAMURA
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Publication number: 20150307884Abstract: The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than ½ of the weight average chain length of one ssRNA constituting the second chain.Type: ApplicationFiled: December 6, 2013Publication date: October 29, 2015Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Tetsuo NAKANO, Eitora YAMAMURA
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Patent number: 8900830Abstract: A process for efficiently producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1?H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps, and the step 2 is performed by using a non-animal-derived enzyme.Type: GrantFiled: July 28, 2011Date of Patent: December 2, 2014Assignees: Sumitomo Dainippon Pharma Co., Ltd., Kyowa Hakko Bio Co., Ltd.Inventors: Shinji Kita, Kazuya Tsuzaki, Eitora Yamamura
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Publication number: 20130196388Abstract: A process for efficiently producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1?H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps, and the step 2 is performed by using a non-animal-derived enzyme.Type: ApplicationFiled: July 28, 2011Publication date: August 1, 2013Applicants: KYOWA HAKKO BIO CO., LTD., DAINIPPON SUMITOMO PHARMA CO., LTD.Inventors: Shinji Kita, Kazuya Tsuzaki, Eitora Yamamura
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Publication number: 20090042275Abstract: A shuttle vector is constructed by preparing a DNA region replicable in bacteria belonging to the genus Rhodococcus from a Rhodococcus-derived plasmid having the nucleotide sequence set forth as SEQ ID NO: 73 and a plasmid or its DNA fragment having the nucleotide sequence set forth as SEQ ID NO: 74, and a DNA region replicable in E. coli from an E. coli-derived plasmid or its DNA fragment. An aminoketone asymmetric reductase gene is inserted into the shuttle vector, transformants containing the vector are created, and the aminoketone asymmetric reductase and optically active aminoalcohols are produced.Type: ApplicationFiled: September 11, 2008Publication date: February 12, 2009Applicant: Daiichi Fine Chemical Co., Ltd.Inventors: Eitora Yamamura, Noboru Fujimoto
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Patent number: 7446187Abstract: A shuttle vector is constructed by preparing a DNA region replicable in bacteria belonging to the genus Rhodococcus from a Rhodococcus-derived plasmid having the nucleotide sequence set forth as SEQ ID NO: 73 and a plasmid or its DNA fragment having the nucleotide sequence set forth as SEQ ID NO: 74, and a DNA region replicable in E. coli from an E. coli-derived plasmid or its DNA fragment. An aminoketone asymmetric reductase gene is inserted into the shuttle vector, transformants containing the vector are created, and the aminoketone asymmetric reductase and optically active aminoalcohols are produced.Type: GrantFiled: October 29, 2004Date of Patent: November 4, 2008Assignee: Daiichi Fine Chemical Co., Ltd.Inventors: Eitora Yamamura, Noboru Fujimoto
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Publication number: 20070031948Abstract: A shuttle vector is constructed by preparing a DNA region replicable in bacteria belonging to the genus Rhodococcus from a Rhodococcus-derived plasmid having the nucleotide sequence set forth as SEQ ID NO: 73 and a plasmid or its DNA fragment having the nucleotide sequence set forth as SEQ ID NO: 74, and a DNA region replicable in E. coli from an E. coli-derived plasmid or its DNA fragment. An aminoketone asymmetric reductase gene is inserted into the shuttle vector, transformants containing the vector are created, and the aminoketone asymmetric reductase and optically active aminoalcohols are produced.Type: ApplicationFiled: October 29, 2004Publication date: February 8, 2007Inventors: Eitora Yamamura, Noboru Fujimoto