Abstract: The present invention relates to compositions and methods for treatment of cholangiocarcinoma and in particular to combination therapies comprising panobinostat compositions in combination with other cytotoxic agents, e.g. agents that potentiate the effects of panobinostat, for use in the treatment of cholangiocarcinoma. Pharmaceutical compositions comprising panobinostat and other cytotoxic agents are also provided.

Abstract: The present application relates to a method for introducing a PNA molecule into the cytosol, preferably the nucleus of a cell, comprising contacting said cell with a PNA molecule and a photosensitising agent, and irradiating the cell with light of a wavelength effective to activate the photosensitising agent, wherein said PNA molecule is conjugated to a positively charged peptide. Compositions comprising such conjugated PNA molecules, cells made using the method and uses of the method are also described.

Abstract: A method for indexing, extracting, analyzing, and utilizing co-occurrences of logical concepts in text documents is disclosed. References to logical concepts are detected by a text processing procedure by detection of descriptors, e.g., names, also including abbreviations, from a hierarchical dictionary with names and synonyms for said logical concepts, or database identifiers. Co-occurring concepts are indexed and stored in a database as a list or a table. Analysis of co-occurrences detects expressed and implied relationships between co-occurring concepts based on statistical and lexical text analysis. The method includes a procedure to create domain-specific hierarchical dictionaries for logical concepts in a given domain.

Abstract: A method for indexing, extracting, analyzing, and utilizing co-occurrences of logical concepts in text documents is disclosed. References to logical concepts are detected by a text processing procedure by detection of descriptors, e.g., names, also including abbreviations, from a hierarchical dictionary with names and synonyms for said logical concepts, or database identifiers. Co-occurring concepts are indexed and stored in a database as a list or a table. Analysis of co-occurrences detects expressed and implied relationships between co-occurring concepts based on statistical and lexical text analysis. The method includes a procedure to create domain-specific hierarchical dictionaries for logical concepts in a given domain.

Abstract: The present invention relates to a method and apparatus for simultaneous quantification of the amounts of one or more radioactive nuclides within arbitrary regions on a surface where these nuclides have been deposited, adsorbed or fixed. These radioactive nuclides serve as markers on compounds that typically have been incorporated into tissue sections or into larger biological molecules that by various mechanisms have been bound to chemical substances on this surface. The method is especially well suited for DNA microarray deductions through the use of nucleotides labelled with different beta-emitting radionuclides.

Abstract: The present invention relates to a method and apparatus for simultaneous quantification of the amounts of one or more radioactive nuclides within arbitrary regions on a surface where these nuclides have been deposited, adsorbed or fixed. These radioactive nuclides serve as markers on compounds that typically have been incorporated into tissue sections or into larger biological molecules that by various mechanisms have been bound to chemical substances on this surface. The method is especially well suited for DNA microarray deductions through the use of nucleotides labelled with different beta-emitting radionuclides.

Abstract: Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

Abstract: Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

Abstract: Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.