Patents by Inventor Ekambaram Balaraman

Ekambaram Balaraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200384451
    Abstract: The present invention discloses a phosphine free cobalt based catalyst of formula (I) and a process for preparation thereof. The present invention further discloses a process for the synthesis of aromatic heterocyclic compounds of formula (II) and pyrazine derivative using the phosphine free cobalt based catalyst of formula (I).
    Type: Application
    Filed: September 5, 2018
    Publication date: December 10, 2020
    Inventors: Ekambaram BALARAMAN, Siba Prasad MIDYA, Vinod Gokulkrishna LANDGE
  • Publication number: 20200317615
    Abstract: The present invention relates to a Palladium (II)-catalyzed C(sp3)—H alkynylation of amines using picolinamide as directing group. The developed alkynylation strategy is simple, efficient, and tolerant of various ring size including five to eight member cyclic, quaternary amines, and N-heterocyclic motifs.
    Type: Application
    Filed: May 22, 2019
    Publication date: October 8, 2020
    Inventors: Ekambaram Balaraman, Vinod Gokulkrishna Landge, Akash Mondal
  • Patent number: 10787418
    Abstract: The present invention relates to a Palladium (II)-catalyzed C(sp3)-H alkynylation of amines using picolinamide as directing group. The developed alkynylation strategy is simple, efficient, and tolerant of various ring size including five to eight member cyclic, quaternary amines, and N-heterocyclic motifs.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: September 29, 2020
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ekambaram Balaraman, Vinod Gokulkrishna Landge, Akash Mondal
  • Patent number: 10758896
    Abstract: The present invention relates to a novel phenonthroline based pincer complexes and process for preparation thereof. The present invention also provides a one pot process for the conversion of carbon dioxide to methanol in the presence of a molecularly defined pincer-type single-site Ru-catalyst and secondary amine. Further the present invention provides the use of phenonthroline based pincer complexes for the esterification of alcohols and hydrogenation of esters under mild conditions.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: September 1, 2020
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Ekambaram Balaraman, Vinod Gokulkrishna Landge, Siba Prasad Midya, Manoj Kumar Sahoo, Garima Jaiswal
  • Publication number: 20200223880
    Abstract: The present invention discloses a cobalt compound of formula (I), a process for the preparation and use thereof. The present invention further relates to a pharmaceutical composition and a method inhibition of Tau Aggregation in a subject in need thereof using compound of formula (I).
    Type: Application
    Filed: June 6, 2018
    Publication date: July 16, 2020
    Inventors: Subashchandrabose CHINNATHAMBI, Ekambaram BALARAMAN, Nalini Vijay GORANTLA, Siba Prasad MIDYA
  • Publication number: 20190329232
    Abstract: The present invention relates to a novel phenonthroline based pincer complexes and process for preparation thereof. The present invention also provides a one pot process for the conversion of carbon dioxide to methanol in the presence of a molecularly defined pincer-type single-site Ru-catalyst and secondary amine. Further the present invention provides the use of phenonthroline based pincer complexes for the esterification of alcohols and hydrogenation of esters under mild conditions.
    Type: Application
    Filed: July 10, 2019
    Publication date: October 31, 2019
    Inventors: Ekambaram BALARAMAN, Vinod Gokulkrishna LANDGE, Siba Prasad MIDYA, Manoj Kumar SAHOO, Garima JAISWAL
  • Patent number: 10449529
    Abstract: The present invention relates to a novel phenonthroline based pincer complexes and process for preparation thereof. The present invention also provides a one pot process for the conversion of carbon dioxide to methanol in the presence of a molecularly defined pincer-type single-site Ru-catalyst and secondary amine. Further the present invention provides the use of phenonthroline based pincer complexes for the esterification of alcohols and hydrogenation of esters under mild conditions.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: October 22, 2019
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Ekambaram Balaraman, Vinod Gokulkrishna Landge, Siba Prasad Midya, Manoj Kumar Sahoo, Garima Jaiswal
  • Patent number: 10335775
    Abstract: The present invention discloses an iron-based nitrogen doped graphene catalyst, process for preparation thereof and use of said catalyst in oxidant-free catalytic dehydrogenation of alcohols and amines to the corresponding carbonyl compounds, amines and N-heterocylic compounds with extraction of molecular hydrogen as the only by-product.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: July 2, 2019
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Ekambaram Balaraman, Dinesh Jagadeesan, Garima Jaiswal, Sanjay Pandurang Borikar
  • Patent number: 10227355
    Abstract: The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 12, 2019
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ekambaram Balaraman, Siba Prasad Midya, Garima Jaiswal
  • Publication number: 20180237448
    Abstract: The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.
    Type: Application
    Filed: February 3, 2016
    Publication date: August 23, 2018
    Inventors: Ekambaram BALARAMAN, Siba Prasad MIDYA, Garima JAISWAL
  • Publication number: 20180147568
    Abstract: The present invention discloses an iron-based nitrogen doped graphene catalyst, process for preparation thereof and use of said catalyst in oxidant-free catalytic dehydrogenation of alcohols and amines to the corresponding carbonyl compounds, amines and N-heterocylic compounds with extraction of molecular hydrogen as the only by-product.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 31, 2018
    Inventors: Ekambaram Balaraman, Dinesh Jagadeesan, Garima Jaiswal, Sanjay Pandurang Borikar
  • Patent number: 9944579
    Abstract: A phosphorus ligand-free, mild, efficient and complete catalytic hydrogenation process is for the sustainable production of terminal diols from renewable terminal dialkyl esters with improved yield. Soluble, phosphorus ligand free Ru (II)-pincer type complexes can be used as catalysts in the hydrogenation process.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: April 17, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ekambaram Balaraman, Manoj Kumar Sahoo
  • Publication number: 20180021766
    Abstract: The present invention relates to a novel phenonthroline based pincer complexes and process for preparation thereof. The present invention also provides a one pot process for the conversion of carbon dioxide to methanol in the presence of a molecularly defined pincer-type single-site Ru-catalyst and secondary amine. Further the present invention provides the use of phenonthroline based pincer complexes for the esterification of alcohols and hydrogenation of esters under mild conditions.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 25, 2018
    Inventors: Ekambaram BALARAMAN, Vinod Gokulkrishna LANDGE, Siba Prasad MIDYA, Manoj Kumar SAHOO, Garima JAISWAL
  • Publication number: 20170349514
    Abstract: A phosphorus ligand-free, mild, efficient and complete catalytic hydrogenation process is for the sustainable production of terminal diols from renewable terminal dialkyl esters with improved yield. Soluble, phosphorus ligand free Ru (II)-pincer type complexes can be used as catalysts in the hydrogenation process.
    Type: Application
    Filed: January 15, 2016
    Publication date: December 7, 2017
    Inventors: Ekambaram BALARAMAN, Manoj Kumar SAHOO
  • Patent number: 9738685
    Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 22, 2017
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Milstein, Chidambaram Gunanathan, Yehoshua Ben-David, Ekambaram Balaraman, Boopathy Gnanaprakasam, Jing Zhang
  • Publication number: 20170107251
    Abstract: The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines.
    Type: Application
    Filed: November 18, 2016
    Publication date: April 20, 2017
    Inventors: David MILSTEIN, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang
  • Publication number: 20160152663
    Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Inventors: David MILSTEIN, Chidambaram GUNANATHAN, Yehoshua BEN-DAVID, Ekambaram BALARAMAN, Boopathy GNANAPRAKASAM, Jing ZHANG
  • Patent number: 9290441
    Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: March 22, 2016
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Milstein, Chidambaram Gunanathan, Yehoshua Ben-David, Ekambaram Balaraman, Boopathy Gnanaprakasam, Jing Zhang
  • Publication number: 20150284417
    Abstract: The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines.
    Type: Application
    Filed: May 1, 2015
    Publication date: October 8, 2015
    Inventors: David MILSTEIN, Ekambaram BALARAMAN, Chidambaram GUNANATHAN, Boopathy GNANAPRAKASAM, Jing ZHANG
  • Patent number: 9045381
    Abstract: The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 2, 2015
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Milstein, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang