Patents by Inventor Ekaterina Aleksandrovna Kutukova

Ekaterina Aleksandrovna Kutukova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for secretory production of protein
    Patent number: 9187554
    Abstract: A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that the activity of a penicillin-binding protein is reduced and in which the activity of a cell surface layer protein has been reduced as an expression host, a heterologous protein is produced by secretory production.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: November 17, 2015
    Assignee: AJINOMOTO CO., INC.
    Inventors: Yoshihiko Matsuda, Hiroshi Itaya, Yoshimi Kikuchi, Haruki Beppu, Jurgis Antanas Vladovich Jomantas, Ekaterina Aleksandrovna Kutukova
  • Method for producing purine nucleosides and nucleotides by fermentation using bacterium belonging to the genus or
    Patent number: 9012182
    Abstract: Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5?-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein from Bacillus amyloliquefaciens and the gene encoding it.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: April 21, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Natalia Pavlovna Zakataeva, Vitaly Arkadievich Livshits, Sergey Viktorovich Gronsky, Ekaterina Aleksandrovna Kutukova, Anna Evgenievna Novikova, Yury Ivanovich Kozlov
  • Method for Secretory Production of Protein
    Publication number: 20140255996
    Abstract: A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that the activity of a penicillin-binding protein is reduced and in which the activity of a cell surface layer protein has been reduced as an expression host, a heterologous protein is produced by secretory production.
    Type: Application
    Filed: April 29, 2014
    Publication date: September 11, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yoshihiko Matsuda, Hiroshi Itaya, Yoshimi Kikuchi, Haruki Beppu, Jurgis Antanas Vladovich Jomantas, Ekaterina Aleksandrovna Kutukova
  • Method for producing purine nucleosides and nucleotides by fermentation using a bacterium belonging to the genus or
    Patent number: 8034767
    Abstract: A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5?-purine nucleotide such as 5?-inosinic acid or 5?-guanylic acid, using a bacterium belonging to the either genus Escherichia or genus Bacillus, wherein purine nucleoside productivity of said bacterium is enhanced by enhancing an activity of a protein encoded by the yeaS (leuE) gene.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: October 11, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Ekaterina Aleksandrovna Kutukova, Natalia Pavlovna Zakataeva, Vitaly Arkadievich Livshits
  • METHOD FOR PRODUCING PURINE NUCLEOSIDES AND NUCLEOTIDES BY FERMENTATION USING A BACTERIUM BELONGING TO THE GENUS ESCHERICHIA OR BACILLUS
    Publication number: 20090298127
    Abstract: A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5?-purine nucleotide such as 5?-inosinic acid or 5?-guanylic acid, using a bacterium belonging to the either genus Escherichia or genus Bacillus, wherein purine nucleoside productivity of said bacterium is enhanced by enhancing an activity of a protein encoded by the yeaS (leuE) gene.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 3, 2009
    Inventors: EKATERINA ALEKSANDROVNA KUTUKOVA, NATALIA PAVLOVNA ZAKATAEVA, VITALY ARKADIEVICH LIVSHITS
  • Method for Producing Purine Nucleosides and Nucleotides by Fermentation Using Bacterium Belonging to the Genus Bacillus or Escherichia
    Publication number: 20080241888
    Abstract: Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5?-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein from Bacillus amyloliquefaciens and the gene encoding it.
    Type: Application
    Filed: September 29, 2006
    Publication date: October 2, 2008
    Inventors: Natalia Pavlovna Zakataeva, Vitaly Arkadievich Livshits, Sergey Viktorovich Gronsky, Ekaterina Aleksandrovna Kutukova, Anna Evgenievna Novikova, Yury Ivanovich Kozlov
  • Method for producing xanthosine-5'-monophosphate by fermentation using mutant strains of Coryneform bacteria
    Publication number: 20020098552
    Abstract: Xanthosine-5′-monophosphate is produced by cultivating the bacterium which has a resistance to growth inhibition by an inhibitor selected from the group consisting of inhibitors of cell membrane biosynthesis and/or functioning, phosphorylation inhibitors, uncoupling agents, RNA-polymerase inhibitors and methionine analogs, and has an ability to produce xanthosine-5′-monophosphate according to produce and accumulate xanthosine-5′-monophosphate in the culture, and recovering the xanthosine-5′-monophosphate therefrom.
    Type: Application
    Filed: November 19, 2001
    Publication date: July 25, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Vitaliy Arkadyevich Livshits, Lyudmila Anatolievna Kazarinova, Sergey Viktorovich Gronskiy, Ekaterina Aleksandrovna Kutukova, Natalia Pavlovna Zakataeva