Abstract: Disclosed herein are compositions and methods for modulating cereblon neosubstrates. A small molecule modulator of Formula (I*), or a pharmaceutically acceptable salt or solvate thereof can be used to modulate cereblon neosubstrates.

Abstract: Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO: 1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3.

Abstract: Disclosed herein are compositions and methods for modulating cereblon neosubstrates. A small molecule modulator of Formula (I*), or a pharmaceutically acceptable salt or solvate thereof can be used to modulate cereblon neosubstrates.

Abstract: Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3.

Abstract: Disclosed herein are compositions and methods for modulating cereblon neosubstrates. A small molecule modulator of Formula (I*), or a pharmaceutically acceptable salt or solvate thereof can be used to modulate cereblon neosubstrates.

Abstract: Certain embodiments are directed to systems and methods using surface enhanced Raman scattering (SERS) detection. More specifically, the present invention describes a system and method of use for SERS detection of sialic (N-acetylneuraminic acid) using citrate-reduced silver nanoparticles.

Abstract: Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3.

Abstract: In some embodiments, an anti-corrosive composite ceramic coating includes an inner metal layer formed on the surface of a metal object to be protected and an outer composite ceramic layer formed on the inner metal layer.

Abstract: Certain embodiments are directed to systems and methods using surface enhanced Raman scattering (SERS) detection. More specifically, the present invention describes a system and method of use for SERS detection of sialic (N-acetylneuraminic acid) using citrate-reduced silver nanoparticles.

Abstract: In some embodiments, an anti-corrosive composite ceramic coating includes an inner metal layer formed on the surface of a metal object to be protected and an outer composite ceramic layer formed on the inner metal layer.

Abstract: For fire fighting and emergency rescue in high-rise buildings the building can be equipped with rails on the outside of the building. The rails have elevators, which travel on the rails on the outside face of the building. Two elevators traveling in unison and supporting a platform extending therebetween can provide a corridor and or a scaffold for reaching anyplace on the face of a building. Other elevators or elevators with cranes can be used on the rails in combination with the elevators with the platform to fight fires, rescue people from the upper floors of buildings or perform maintenance or construction tasks.

Abstract: For fire fighting and emergency rescue in high-rise buildings the building can be equipped with rails on the outside of the building. The rails have elevators, which travel on the rails on the outside face of the building. Two elevators traveling in unison and supporting a platform extending therebetween can provide a corridor and or a scaffold for reaching anyplace on the face of a building. Other elevators or elevators with cranes can be used on the rails in combination with the elevators with the platform to fight fires, rescue people from the upper floors of buildings or perform maintenance or construction tasks.