Patents by Inventor Ekkehard Baader

Ekkehard Baader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-and 2,5-bistetrazolylpyridines, a process for the preparation thereof and the use thereof as pharmaceuticals
    Patent number: 5614537
    Abstract: The invention relates 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 25, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerrit Schubert, Ekkehard Baader, Martin Bickel, Volkmar G unzler-Pukall
  • N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamines
    Patent number: 5519038
    Abstract: The invention relates to N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides of the formula I ##STR1## wherein R.sup.1, R.sup.2, n, R.sup.1', R.sup.2' and n' have the meanings given. The compounds inhibit proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: May 21, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals
    Patent number: 5482953
    Abstract: The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: January 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerrit Schubert, Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments
    Patent number: 5356909
    Abstract: The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: October 18, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Dietrich Brocks, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel
  • 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
    Patent number: 5260323
    Abstract: 2,4- and 2,5-substituted pyridine-N-oxides are provided which are effective as fibrosuppressives and immunosuppressives. Said compounds are also suitable for the treatment of disorders of the metabolism of collagen and collagen-like substances or the biosynthesis of Clq.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: November 9, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for their preparation and their use
    Patent number: 5240921
    Abstract: The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: August 31, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall
  • Oxalylamino acid derivatives and their use as medicaments for inhibiting proline hydroxylase
    Patent number: 5204338
    Abstract: The invention relates to oxalylamino acid derivatives of the formula I ##STR1## in which R and R' are identical or different and are C.sub.1 -C.sub.6 -alkyl or hydrogen,R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.3 -alkoxy, carboxyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, aryl, SH, NH.sub.2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH.sub.2orR.sup.1 and R.sup.2 together are a C.sub.2 -C.sub.4 -alkylene chain and the compounds in their predominantly pure D- and L-form and the physiologically tolerable salts.The compounds are distinguished as excellent inhibitors of prolyl hydroxylase and lysine hydroxylase.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: April 20, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Harald Burghard, Volkmar Gunzler-Pukall
  • Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use thereof
    Patent number: 5143926
    Abstract: The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: September 1, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Dietrich Brocks, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel
  • Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compounds
    Patent number: 5130317
    Abstract: Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compoundsThe invention relates to pyrimidine-4,6-dicarboxylic acid diamides of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can be employed as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: July 14, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Volkmar Gunzler-Pukall, Stephan Henke
  • 7(1H-pyrrol-3-YL)-substituted 3,5-dihydroxyhept-6-enoic acids, 7-(1H-pyrrol-3-YL)-substituted 3,5-dihyroxyhept-anoic acids, their corresponding delta-lactones and salts, their use as medicaments and pharmaceutical products and intermediates
    Patent number: 5055484
    Abstract: 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids, 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyheptanoic acids of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the indicated meanings, and the corresponding .delta.-lactones of the formula II ##STR2## processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: October 8, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heiner Jendralla, Gerhard Beck, Ekkehard Baader, Bela Kerekjarto
  • Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds
    Patent number: 5004748
    Abstract: The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.
    Type: Grant
    Filed: March 4, 1988
    Date of Patent: April 2, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Baader, Martin Bickel, Dietrich Brocks, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel
  • Process for the preparation of optically active 3-demethylmevalonic acid derivatives, and intermediates
    Patent number: 4977279
    Abstract: A process for the preparation of optically active 3-demethylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: December 11, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Wess, Kurt Kesseler, Ekkehard Baader, Gerhard Beck
  • Optically active 3-demethylmevalonic acid derivatives, and intermediates
    Patent number: 4970313
    Abstract: A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## (.beta.-hydroxy lactones) in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: November 13, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Wess, Kurt Kesseler, Ekkehard Baader, Gerhard Beck
  • Pyridazine 3,5-dihydroxy carboxylic acids and derivatives thereof, the use thereof for hypercholesterolemia
    Patent number: 4946841
    Abstract: New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates 3,5-Dihydroxy carboxylic acids and derivatives thereof, of the formula I ##STR1## and the corresponding Lactones of the formula II ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X-Y have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.
    Type: Grant
    Filed: January 6, 1989
    Date of Patent: August 7, 1990
    Assignee: Hoechst Aktiengesellachaft
    Inventors: Ekkehard Baader, Heiner Jendralla, Bela Kerekjarto, Gerhard Beck