Patents by Inventor El Bachir Kaloun
El Bachir Kaloun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10544156Abstract: The invention concerns a compound of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof as well as a pharmaceutical composition containing such a compound, and the use of such a compound as a drug, notably as a DNMT inhibitor, in particular in the treatment of cancer.Type: GrantFiled: October 3, 2016Date of Patent: January 28, 2020Assignees: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Ludovic Halby, Yoann Menon, El Bachir Kaloun, Christophe Long, Paola B. Arimondo
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Patent number: 10519125Abstract: The invention relates to compounds of the following general formula (I) in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof, and the pharmaceutically acceptable salts and/or solvates thereof, especially for the use thereof as a medicament, more specifically in cancer treatment. The invention also relates to pharmaceutical compositions containing same and to the methods for the production thereof.Type: GrantFiled: December 1, 2017Date of Patent: December 31, 2019Assignee: PIERRE FABRE MEDICAMENTInventors: Frédéric Marion, El Bachir Kaloun, Frédéric Lieby-Muller, Michel Perez, Jean-Philippe Annereau, Laurent Creancier
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Patent number: 10323043Abstract: The present invention relates to a compound with the following formula (I): (I) or a salt and/or a pharmaceutically acceptable solvate thereof, in particular for use as a drug, in particular in the treatment of cancer, as well as to the pharmaceutical compositions that contain same and to the methods for preparing same.Type: GrantFiled: September 2, 2015Date of Patent: June 18, 2019Assignee: PIERRE FABRE MEDICAMENTInventors: El Bachir Kaloun, Serge Grisoni, Anna Kruczynski, Philippe Schmitt
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Publication number: 20190062339Abstract: The invention concerns a compound of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof as well as a pharmaceutical composition containing such a compound, and the use of such a compound as a drug, notably as a DNMT inhibitor, in particular in the treatment of cancer.Type: ApplicationFiled: October 3, 2016Publication date: February 28, 2019Applicants: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Ludovic HALBY, Yoann MENON, El Bachir KALOUN, Christophe LONG, Paola B. ARIMONDO
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Patent number: 10047064Abstract: The invention relates to compounds of the following general formula (I) in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof, and the pharmaceutically acceptable salts and/or solvates thereof, especially for the use thereof as a medicament, more specifically in cancer treatment. The invention also relates to pharmaceutical compositions containing same and to the methods for the production thereof.Type: GrantFiled: July 6, 2015Date of Patent: August 14, 2018Assignee: PIERRE FABRE MEDICAMENTInventors: Frédéric Marion, El Bachir Kaloun, Frédéric Lieby-Muller, Michel Perez, Jean-Philippe Annereau, Laurent Creancier
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Patent number: 9944641Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as a drug, notably in the treatment of cancer, as well as pharmaceutical compositions containing such a compound and processes to prepare such a compound.Type: GrantFiled: September 2, 2015Date of Patent: April 17, 2018Assignee: PIERRE FABRE MEDICAMENTInventors: El Bachir Kaloun, Philippe Schmitt, Anna Kruczynski
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Publication number: 20180086729Abstract: The invention relates to compounds of the following general formula (I) in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof, and the pharmaceutically acceptable salts and/or solvates thereof, especially for the use thereof as a medicament, more specifically in cancer treatment. The invention also relates to pharmaceutical compositions containing same and to the methods for the production thereof.Type: ApplicationFiled: December 1, 2017Publication date: March 29, 2018Applicant: PIERRE FABRE MEDICAMENTInventors: Frédéric MARION, El Bachir KALOUN, Frédéric LIEBY-MULLER, Michel PEREZ, Jean-Philippe ANNEREAU, Laurent CREANCIER
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DERIVATIVES OF MACROCYCLIC N-ARYL-2-AMINO-4-ARYL-PYRIMIDINE POLYETHERS AS INHIBITORS OF FTL3 AND JAK
Publication number: 20170281622Abstract: The present invention relates to a compound with the following formula: formula (I) or a salt and/or a pharmaceutically acceptable solvate thereof, in particular for use as a drug, in particular in the treatment of cancer, as well as to the pharmaceutical compositions that contain same and to the methods for preparing same.Type: ApplicationFiled: September 2, 2015Publication date: October 5, 2017Applicant: PIERRE FABRE MEDICAMENTInventors: El Bachir KALOUN, Serge GRISONI, Bruno GOMES, Philippe SCHMITT -
Publication number: 20170283432Abstract: The present invention relates to a compound with the following formula (I): (I) or a salt and/or a pharmaceutically acceptable solvate thereof, in particular for use as a drug, in particular in the treatment of cancer, as well as to the pharmaceutical compositions that contain same and to the methods for preparing same.Type: ApplicationFiled: September 2, 2015Publication date: October 5, 2017Applicant: PIERRE FABRE MEDICAMENTInventors: El Bachir KALOUN, Serge GRISONI, Anna KRUCZYNSKI, Philippe SCHMITT
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Publication number: 20170240544Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as a drug, notably in the treatment of cancer, as well as pharmaceutical compositions containing such a compound and processes to prepare such a compound.Type: ApplicationFiled: September 2, 2015Publication date: August 24, 2017Applicant: PIERRE FABRE MEDICAMENTInventors: El Bachir KALOUN, Philippe SCHMITT, Anna KRUCZYNSKI
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Publication number: 20170137400Abstract: The invention relates to compounds of the following general formula (I) in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof, and the pharmaceutically acceptable salts and/or solvates thereof, especially for the use thereof as a medicament, more specifically in cancer treatment. The invention also relates to pharmaceutical compositions containing same and to the methods for the production thereof.Type: ApplicationFiled: July 6, 2015Publication date: May 18, 2017Applicant: PIERRE FABRE MEDICAMENTInventors: Frédéric MARION, El Bachir KALOUN, Frédéric LIEBY-MULLER, Michel PEREZ, Jean-Philippe ANNEREAU, Laurent CREANCIER
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Patent number: 9428510Abstract: The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture, as well as pharmaceutical composition comprising such a compound, for use in the treatment of a cancer associated with the overexpression of at least one Trk protein.Type: GrantFiled: July 29, 2013Date of Patent: August 30, 2016Assignee: PIERRE FABRE MEDICAMENTInventors: Anna Kruczynski, Laurent Creancier, El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot
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Publication number: 20150266880Abstract: The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture, as well as pharmaceutical composition comprising such a compound, for use in the treatment of a cancer associated with the overexpression of at least one Trk protein.Type: ApplicationFiled: July 29, 2013Publication date: September 24, 2015Applicant: PIERRE FABRE MEDICAMENTInventors: Anna Kruczynski, Laurent Creancier, El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot
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Patent number: 9085575Abstract: The present invention relates to compounds of following general formula (I): and to the pharmaceutically acceptable salts of same, the tautomers of same, the stereoisomers or mixture of stereoisomers in any proportions of same, such as a mixture of enantiomers, notably a racemic mixture, as well as to methods for preparing same and uses of same, notably as an antineoplastic agent.Type: GrantFiled: April 12, 2012Date of Patent: July 21, 2015Assignee: PIERRE FABRE MEDICAMENTInventors: Rémi Rabot, Karim Bedjeguelal, El Bachir Kaloun, Philippe Schmitt, Nicolas Rahier, Patrice Mayer, Emmanuel Fournier
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Patent number: 8889711Abstract: The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.Type: GrantFiled: October 13, 2010Date of Patent: November 18, 2014Assignee: Pierre Fabre MedicamentInventors: Karim Bedjeguelal, Rémi Rabot, El Bachir Kaloun, Patrice Mayer, Arnaud Marchand, Nicolas Rahier, Philippe Schambel, Hugues Bienayme
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Patent number: 8883821Abstract: The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; as well as to the use of same as a drug, notably intended for the treatment of cancer, inflammation and neurodegenerative diseases such as Alzheimer's disease; to the use of same as a kinase inhibitor; to the pharmaceutical compositions comprising same; and to methods for the preparation of same.Type: GrantFiled: November 27, 2012Date of Patent: November 11, 2014Assignee: Pierre Fabre MedicamentInventors: El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot, Anna Kruczynski, Philippe Schmitt, Michel Perez, Nicolas Rahier
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Publication number: 20140031362Abstract: The present invention relates to compounds of following general formula (I): and to the pharmaceutically acceptable salts of same, the tautomers of same, the stereoisomers or mixture of stereoisomers in any proportions of same, such as a mixture of enantiomers, notably a racemic mixture, as well as to methods for preparing same and uses of same, notably as an antineoplastic agent.Type: ApplicationFiled: April 12, 2012Publication date: January 30, 2014Applicant: PIERRE FABRE MEDICAMENTInventors: Rémi Rabot, Karim Bedjeguelal, El Bachir Kaloun, Philippe Schmitt, Nicolas Rahier, Patrice Mayer, Emmanuel Fournier
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Publication number: 20130172360Abstract: The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; as well as to the use of same as a drug, notably intended for the treatment of cancer, inflammation and neurodegenerative diseases such as Alzheimer's disease; to the use of same as a kinase inhibitor; to the pharmaceutical compositions comprising same; and to methods for the preparation of same.Type: ApplicationFiled: January 27, 2012Publication date: July 4, 2013Applicant: PIERRE FABRE MEDICAMENTInventors: El Bachir Kaloun, Karim Bedjeguelal, Rémi Rabot, Anna Kruczynski, Philippe Schmitt, Michel Perez, Nicolas Rahier
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Publication number: 20120245170Abstract: The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.Type: ApplicationFiled: October 13, 2010Publication date: September 27, 2012Applicant: Pierre Fabre MedicamentInventors: Karim Bedjeguelal, Rémi Rabot, El Bachir Kaloun, Patrice Mayer, Arnaud Marchand, Nicolas Rahier, Philippe Schambel, Hugues Bienayme
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Patent number: 7339061Abstract: Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR? wherein R? represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.Type: GrantFiled: June 18, 2003Date of Patent: March 4, 2008Assignee: Les Laboratoires ServierInventors: Jean-Daniel Brion, Lucien Israel, Alain Le Ridant, Catherine Harpey, Cherif Rabhi, El Bachir Kaloun