Abstract: The transmutation of radioactive material using a hybrid transmutation reactor is disclosed wherein a kinetic proton source is used to collisionally induce the transmutation of radioactive material with the generation of thermal neutrons as a byproduct. Additionally, a system and method for the production of Tritium utilizing the thermal neutrons generated in the transmutation process is further described. The present invention offers advantages and improvements over existing nuclear reactor technologies in that nuclear waste may be rendered inert, or otherwise at least partially deactivated and/or made less dangerous, with the substantially simultaneous production of energy and/or Tritium as a byproduct of the transmutation process.