Patents by Inventor Elaheh Dalir Abdolahinia

Elaheh Dalir Abdolahinia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of target DNA sequences using double-stranded oligonucleotides
    Patent number: 9612222
    Abstract: A method of detection and discrimination of target DNA sequences and of single nucleotide polymorphisms (SNPs) directly on double-stranded DNA (dsDNA) samples without the need for denaturation of the target dsDNAs. This is achieved by the use of a PNA chain as a probe. This probe is self-assembled on a gold electrode; hybridization of the probe with the target dsDNA forms a PNA-dsDNA hybrid. The hybrid is then labeled with a mediator, and the PNA-dsDNA hybridization is monitored. Monitoring of the hybrid formation can be achieved using an electrochemical approach. This method is able to detect and discriminate target DNA sequences and SNPs on ds-oligonucleotides. Furthermore, this method is able to detect and discriminate target DNA sequences and SNPs on double-stranded PCR products.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: April 4, 2017
    Inventors: Mohammad Saeid Hejazi, Esmaeel Alipour, Elaheh Dalir Abdolahinia, Sanam Arami
  • DETECTION AND DISCRIMINATION OF TARGET DNA SEQUENCE AND SINGLE NUCLEOTIDE POLYMORPHISM DIRECTLY ON DOUBLE-STRANDED OLIGONUCLEOTIDE AND PCR PRODUCT WITHOUT DENATURATION OF DSDNA SAMPLE BASED ON PNA-DSDNA HYBRID AND UTILIZING PNA PROBE
    Publication number: 20110186448
    Abstract: A method of detection and discrimination of target DNA sequences and of single nucleotide polymorphisms (SNPs) directly on double-stranded DNA (dsDNA) samples without the need for denaturation of the target dsDNAs. This is achieved by the use of a PNA chain as a probe. This probe is self-assembled on a gold electrode; hybridization of the probe with the target dsDNA forms a PNA-dsDNA hybrid. The hybrid is then labeled with a mediator, and the PNA-dsDNA hybridization is monitored. Monitoring of the hybrid formation can be achieved using an electrochemical approach. This method is able to detect and discriminate target DNA sequences and SNPs on ds-oligonucleotides. Furthermore, this method is able to detect and discriminate target DNA sequences and SNPs on double-stranded PCR products.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 4, 2011
    Inventors: Mohammad Saeid Hejazi, Esmaeel Alipour, Elaheh Dalir Abdolahinia, Sanam Arami