Patents by Inventor Elaine Lai
Elaine Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Medicinal composition comprising a non-coding RNA molecule and an antibody targeting a tumor antigen
Patent number: 11944636Abstract: This invention discloses a medicinal composition includes a non-coding RNA molecule and an antibody targeting a tumor antigen for preventing and/or treating cancer. This invention uses the synergistic combination of a non-coding RNA molecule or its functional variant or homologue, and an antibody targeting a tumor antigen to prevent and/or treat cancer, thereby providing a novel and effective method in preventing and/or treating various cancers.Type: GrantFiled: November 11, 2020Date of Patent: April 2, 2024Assignee: Macau University of Science and TechnologyInventors: Zhi-Hong Jiang, Lee-Fong Yau, Tian-Tian Tong, Hao Huang, Kua Hu, Elaine Lai-Han Leung -
Medicinal composition comprising a non-coding RNA molecule and an antibody targeting a tumor antigen
Publication number: 20220088055Abstract: This invention discloses a medicinal composition includes a non-coding RNA molecule and an antibody targeting a tumor antigen for preventing and/or treating cancer. This invention uses the synergistic combination of a non-coding RNA molecule or its functional variant or homologue, and an antibody targeting a tumor antigen to prevent and/or treat cancer, thereby providing a novel and effective method in preventing and/or treating various cancers.Type: ApplicationFiled: November 11, 2020Publication date: March 24, 2022Inventors: Zhi-Hong Jiang, Lee-Fong Yau, Tian-Tian Tong, Hao Huang, Kua Hu, Elaine Lai-Han Leung -
Publication number: 20210090188Abstract: Aspects of this disclosure relate to determining a health score of properties. For example, data from one or more sensors of each of a plurality of properties may be received from the plurality of properties. Statuses of each property of the plurality of properties may be identified from the data. A health score of a property that is within a vicinity the plurality of properties is determined using the statuses. This health score may providing to a user along with a recommended action to improve the health score.Type: ApplicationFiled: September 24, 2019Publication date: March 25, 2021Inventors: Elaine Lai, Avery Rowe, Susann Marie Keohane, Cristi Nesbitt Ullmann, Tiffany Cross, Fang Lu
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Publication number: 20190179948Abstract: In one embodiment, a method includes receiving an unstructured data record and parsing the unstructured data record to determine a characterization of the unstructured data record. The characterization includes determination of: a number of fields, a length for the fields, and an order of the fields as stored in the unstructured data record. The method also includes obtaining a first key pair that includes a primary key-name associated with a first key-value and hashing at least the first key-value to obtain a hash value. In addition, the method includes updating the unstructured data record to include the hash value as an indexing key thereby creating a modified data record. Also, the method includes storing the modified data record in a structured database. Moreover, the method includes updating an index of the structured database to include an entry for the modified data record, the entry including the hash value.Type: ApplicationFiled: December 12, 2017Publication date: June 13, 2019Inventors: Debra J. Benjamin-Deckert, Neal E. Bohling, Elaine Lai, Lawrence L. Law, Brian Lee, Terri A. Menendez, Gary Pizl, Roity Prieto Perez, Tony Xu
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Publication number: 20190070170Abstract: A method of selectively inhibiting the overexpression of mPGES-1 in a subject in need thereof includes a step of administering an effective amount of a selective mPGES-1 inhibitor or a salt thereof to the subject. A method of treating a subject suffering from a disease associated with an overexpression of mPGES-1 and having a risk of cardiovascular event includes the step of administering an effective amount of a selective mPGES-1 inhibitor to the subject.Type: ApplicationFiled: September 5, 2017Publication date: March 7, 2019Inventors: Hua Zhou, Jian-Xin Liu, Jin-Fang Luo, Chun-Song Chen, Elaine Lai-Han Leung, Liang Liu
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Patent number: 10111876Abstract: A compound for treating a disease, in particular cancer like non-small cell lung cancer, exceptionally inhibits activity of oncogenic ALK kinase. Compositions, particularly pharmaceutical compositions, are provided comprising this compound. Methods for targeting cancer cells harboring an abnormality in the ALK gene are also The compound for treating a disease has certain structural elements, namely a tricyclic, more specifically heterocyclic, backbone as the core part of the compound at least one highly electronegative atom in form of a tertiary amine attached to the backbone via an at most 6-membered linking group with a terminal highly electronegative atom in form of a nitrogen as secondary amine, and a further hydrophobic moiety fused to the backbone. The structural components allow for an advantageous interaction with the ALK kinase domain. The compound therefor represents a highly promising treatment option for patients in particular those bearing ALK-dependent non-small cell lung cancer.Type: GrantFiled: August 17, 2016Date of Patent: October 30, 2018Assignee: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Xiao-Jun Yao, Elaine Lai-Han Leung, Lian-Xiang Luo, Liang Liu
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Publication number: 20180050037Abstract: A compound for treating a disease, in particular cancer like non-small cell lung cancer, exceptionally inhibits activity of oncogenic ALK kinase. Compositions, particularly pharmaceutical compositions, are provided comprising this compound. Methods for targeting cancer cells harboring an abnormality in the ALK gene are also The compound for treating a disease has certain structural elements, namely a tricyclic, more specifically heterocyclic, backbone as the core part of the compound at least one highly electronegative atom in form of a tertiary amine attached to the backbone via an at most 6-membered linking group with a terminal highly electronegative atom in form of a nitrogen as secondary amine, and a further hydrophobic moiety fused to the backbone. The structural components allow for an advantageous interaction with the ALK kinase domain. The compound therefor represents a highly promising treatment option for patients in particular those bearing ALK-dependent non-small cell lung cancer.Type: ApplicationFiled: August 17, 2016Publication date: February 22, 2018Inventors: Xiao-Jun Yao, Elaine Lai-Han Leung, Lian-Xiang Luo, Liang Liu
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Patent number: 9861623Abstract: The present invention provides methods for treatment of a RAS-positive disease, in particular KRAS-positive non-small cell lung cancer as well as a method for potentiating the apoptotic activity of a PDE? inhibitor by combining the PDE? inhibitor with a direct autophagy inhibitor. The PDE? inhibitor is preferably, but not exclusively, deltarasin, and the direct autophagy inhibitor is in particular 3-methyladenine. Further provided by the present invention are a kit and a pharmaceutical composition comprising the PDE? inhibitor and a direct autophagy inhibitor. The methods of the present invention in particular provide a new treatment option for RAS-positive diseases such as KRAS-positive non-small cell lung cancer allowing for an increased apoptotic activity of the PDE? inhibitor by simultaneously blocking its “tumor protective” autophagy.Type: GrantFiled: October 28, 2016Date of Patent: January 9, 2018Assignee: Macau University of Science and TechnologyInventors: Liang Liu, David Ward, Elaine Lai-Han Leung, Xiao Jun Yao, Vincent Kam-Wai Wong, Lian-Xiang Luo
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Patent number: 9855250Abstract: One example embodiment relates to a method of treating lung cancer by administering a compound of formula I to a subject in need thereof. Another embodiment relates to a method to treat Non-Small Cell Lung Cancer (NSCLC) by administering the compound of formula I to a patient.Type: GrantFiled: November 14, 2016Date of Patent: January 2, 2018Assignee: Macau University of Science and TechnologyInventors: Liang Liu, Elaine Lai-Han Leung, Xiao-Jun Yao, Vincent Kam-Wai Wong, Xi Chen
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Patent number: 9439898Abstract: The present invention relates to methods for novel drug discovery, treatment and selective targeting for Gefitinib-resistant non-small-cell lung cancer (NSCLC) harboring an additional mutation, in particular, to the discovery of a drug candidate or agent identified by the presently claimed method for use in treating and selective targeting Gefitinib-resistant NSCLC harboring T790M mutation.Type: GrantFiled: June 5, 2014Date of Patent: September 13, 2016Assignee: Macau University of Science and TechnologyInventors: Elaine Lai-Han Leung, Liang Liu, Xing-Xing Fan
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Publication number: 20150297582Abstract: The present invention relates to methods for novel drug discovery, treatment and selective targeting for Gefitinib-resistant non-small-cell lung cancer (NSCLC) harboring an additional mutation, in particular, to the discovery of a drug candidate or agent identified by the presently claimed method for use in treating and selective targeting Gefitinib-resistant NSCLC harboring T790M mutation.Type: ApplicationFiled: June 5, 2014Publication date: October 22, 2015Applicant: Macau University of Science and TechnologyInventors: Elaine Lai-Han LEUNG, Liang LIU, Xing-Xing FAN
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Patent number: 8986576Abstract: A material consisting essentially of a vinyl thermoplastic polymer, un-functionalized carbon nanotubes and hydroxylated carbon nanotubes dissolved in a solvent. Un-functionalized carbon nanotube concentrations up to 30 wt % and hydroxylated carbon nanotube concentrations up to 40 wt % can be used with even small concentrations of each (less than 2 wt %) useful in producing enhanced conductivity properties of formed thin films.Type: GrantFiled: September 1, 2011Date of Patent: March 24, 2015Assignee: Sandia CorporationInventors: Gregory O'Bryan, Jack L. Skinner, Andrew Vance, Elaine Lai Yang, Thomas Zifer
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Patent number: 8728566Abstract: The present invention is a method of making a composite polymeric material by dissolving a vinyl thermoplastic polymer, un-functionalized carbon nanotubes and hydroxylated carbon nanotubes and optionally additives in a solvent to make a solution and removing at least a portion of the solvent after casting onto a substrate to make thin films. The material has enhanced conductivity properties due to the blending of the un-functionalized and hydroxylated carbon nanotubes.Type: GrantFiled: September 1, 2011Date of Patent: May 20, 2014Assignee: Sandia CorporationInventors: Gregory O'Bryan, Jack L. Skinner, Andrew Vance, Elaine Lai Yang, Thomas Zifer
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Publication number: 20120114841Abstract: The present invention is a method of making a composite polymeric material by dissolving a vinyl thermoplastic polymer, un-functionalized carbon nanotubes and hydroxylated carbon nanotubes and optionally additives in a solvent to make a solution and removing at least a portion of the solvent after casting onto a substrate to make thin films. The material has enhanced conductivity properties due to the blending of the un-functionalized and hydroxylated carbon nanotubes.Type: ApplicationFiled: September 1, 2011Publication date: May 10, 2012Inventors: Gregory O'Bryan, Jack L. Skinner, Andrew Vance, Elaine Lai Yang, Thomas Zifer
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Patent number: 6162302Abstract: A cleaning method for a quartz substrate includes mixing a rinsing solution and mixing a cleaning solution such that the solutions are electrically conductive. The rinsing solution is carbonated and is used in more than one step within the method. The cleaning solution includes ammonium hydroxide. As a result of the electrical conductivity of the solutions, the cleaning method is less susceptible to surface damage caused by electrostatic discharge. The sequence of steps includes rinsing the quartz substrate with the carbonated rinsing solution, removing loose contaminants by a high pressure application of the cleaning solution, and removing organic contaminants in a strong oxidation environment using a solution of sulfuric acid and hydrogen peroxide. The carbonated rinsing solution is again applied, followed by another high pressure application of the cleaning solution and a final rinse with the carbonated rinsing solution.Type: GrantFiled: November 16, 1999Date of Patent: December 19, 2000Assignee: Agilent TechnologiesInventors: Nadipuram V. Vijaya Raghavan, Elaine Lai-Yee Leung