Patents by Inventor Elaine To

Elaine To has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12018090
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 25, 2024
    Assignee: Rani Therapeutics, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Publication number: 20230374155
    Abstract: Embodiments provide swallow-able devices, preparations and methods for delivering therapeutic agents (FAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Application
    Filed: May 19, 2023
    Publication date: November 23, 2023
    Applicant: Rani Therapeutics, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Patent number: 11718665
    Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: August 8, 2023
    Assignee: RANI THERAPEUTICS, LLC
    Inventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Publication number: 20230174639
    Abstract: Described are swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP), particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the 1W and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments of the invention are particularly useful for the delivery of interleukin NP’ s (INP) for treatment of inflammatory conditions where such INP’s are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Application
    Filed: December 9, 2022
    Publication date: June 8, 2023
    Applicant: Rani Therapeutics, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
  • Patent number: 11548940
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: January 10, 2023
    Assignee: Rani Therapeutics, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
  • Publication number: 20200247906
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 6, 2020
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Patent number: 10689460
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 23, 2020
    Assignee: Incube Labs, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Patent number: 10568502
    Abstract: Techniques for a visual disability detection system that employs virtual reality to assess visual performance of a patient based on activities of daily living are described. The virtual reality platform can integrate the testing of different components of visual function based on activities of daily living to provide a direct and clinically relevant measure of the impact of any visual disability on a patient's daily life. By simulating daily tasks for evaluation of visual disability, clinicians can better understand from a patient's perspective how visual impairment affects their daily tasks and quality of life.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: February 25, 2020
    Assignee: The Chinese University of Hong Kong
    Inventors: Kai Shun Christopher Leung, Ka Ngai Alexander Lam, Yuen Ying Elaine To
  • Publication number: 20190211094
    Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
    Type: Application
    Filed: January 15, 2019
    Publication date: July 11, 2019
    Inventors: Mir IMRAN, Mercedes MORALES, Radhika KORUPOLU, Elaine TO, Joel HARRIS, Mir HASHIM
  • Patent number: 10227403
    Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: March 12, 2019
    Assignee: InCube Labs, LLC
    Inventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Publication number: 20190062451
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Application
    Filed: September 8, 2016
    Publication date: February 28, 2019
    Applicant: Incube Labs, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Publication number: 20180251537
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.
    Type: Application
    Filed: May 9, 2016
    Publication date: September 6, 2018
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
  • Publication number: 20180208651
    Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
    Type: Application
    Filed: May 2, 2016
    Publication date: July 26, 2018
    Applicant: INCUBE LABS, LLC
    Inventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Publication number: 20180037643
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.
    Type: Application
    Filed: May 9, 2016
    Publication date: February 8, 2018
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
  • Publication number: 20170273552
    Abstract: Techniques for a visual disability detection system that employs virtual reality to assess visual performance of a patient based on activities of daily living are described. The virtual reality platform can integrate the testing of different components of visual function based on activities of daily living to provide a direct and clinically relevant measure of the impact of any visual disability on a patient's daily life. By simulating daily tasks for evaluation of visual disability, clinicians can better understand from a patient's perspective how visual impairment affects their daily tasks and quality of life.
    Type: Application
    Filed: March 22, 2017
    Publication date: September 28, 2017
    Inventors: Kai Shun Christopher LEUNG, Ka Ngai Alexander LAM, Yuen Ying Elaine TO
  • Publication number: 20170066824
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.
    Type: Application
    Filed: May 9, 2016
    Publication date: March 9, 2017
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
  • Publication number: 20170066841
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Application
    Filed: September 8, 2016
    Publication date: March 9, 2017
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Publication number: 20170051051
    Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
    Type: Application
    Filed: May 2, 2016
    Publication date: February 23, 2017
    Inventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim