Patents by Inventor Elaine To
Elaine To has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12018090Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: GrantFiled: April 24, 2020Date of Patent: June 25, 2024Assignee: Rani Therapeutics, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Publication number: 20230374155Abstract: Embodiments provide swallow-able devices, preparations and methods for delivering therapeutic agents (FAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: ApplicationFiled: May 19, 2023Publication date: November 23, 2023Applicant: Rani Therapeutics, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Patent number: 11718665Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: GrantFiled: January 15, 2019Date of Patent: August 8, 2023Assignee: RANI THERAPEUTICS, LLCInventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Publication number: 20230174639Abstract: Described are swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP), particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the 1W and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments of the invention are particularly useful for the delivery of interleukin NP’ s (INP) for treatment of inflammatory conditions where such INP’s are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: December 9, 2022Publication date: June 8, 2023Applicant: Rani Therapeutics, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
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Patent number: 11548940Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.Type: GrantFiled: May 9, 2016Date of Patent: January 10, 2023Assignee: Rani Therapeutics, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
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Publication number: 20200247906Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: ApplicationFiled: April 24, 2020Publication date: August 6, 2020Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Patent number: 10689460Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: GrantFiled: September 8, 2016Date of Patent: June 23, 2020Assignee: Incube Labs, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Patent number: 10568502Abstract: Techniques for a visual disability detection system that employs virtual reality to assess visual performance of a patient based on activities of daily living are described. The virtual reality platform can integrate the testing of different components of visual function based on activities of daily living to provide a direct and clinically relevant measure of the impact of any visual disability on a patient's daily life. By simulating daily tasks for evaluation of visual disability, clinicians can better understand from a patient's perspective how visual impairment affects their daily tasks and quality of life.Type: GrantFiled: March 22, 2017Date of Patent: February 25, 2020Assignee: The Chinese University of Hong KongInventors: Kai Shun Christopher Leung, Ka Ngai Alexander Lam, Yuen Ying Elaine To
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Publication number: 20190211094Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: ApplicationFiled: January 15, 2019Publication date: July 11, 2019Inventors: Mir IMRAN, Mercedes MORALES, Radhika KORUPOLU, Elaine TO, Joel HARRIS, Mir HASHIM
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Patent number: 10227403Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: GrantFiled: May 2, 2016Date of Patent: March 12, 2019Assignee: InCube Labs, LLCInventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Publication number: 20190062451Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: ApplicationFiled: September 8, 2016Publication date: February 28, 2019Applicant: Incube Labs, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Publication number: 20180251537Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.Type: ApplicationFiled: May 9, 2016Publication date: September 6, 2018Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
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Publication number: 20180208651Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: ApplicationFiled: May 2, 2016Publication date: July 26, 2018Applicant: INCUBE LABS, LLCInventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Publication number: 20180037643Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.Type: ApplicationFiled: May 9, 2016Publication date: February 8, 2018Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
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Publication number: 20170273552Abstract: Techniques for a visual disability detection system that employs virtual reality to assess visual performance of a patient based on activities of daily living are described. The virtual reality platform can integrate the testing of different components of visual function based on activities of daily living to provide a direct and clinically relevant measure of the impact of any visual disability on a patient's daily life. By simulating daily tasks for evaluation of visual disability, clinicians can better understand from a patient's perspective how visual impairment affects their daily tasks and quality of life.Type: ApplicationFiled: March 22, 2017Publication date: September 28, 2017Inventors: Kai Shun Christopher LEUNG, Ka Ngai Alexander LAM, Yuen Ying Elaine TO
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Publication number: 20170066824Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW.Type: ApplicationFiled: May 9, 2016Publication date: March 9, 2017Inventors: Mir Imran, Radhika Korupolu, Elaine To, Mir Hashim
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Publication number: 20170066841Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: ApplicationFiled: September 8, 2016Publication date: March 9, 2017Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
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Publication number: 20170051051Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: ApplicationFiled: May 2, 2016Publication date: February 23, 2017Inventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim