Abstract: The present application relates to particular anti-PAD4 (peptidyl arginine deiminase 4) antibodies, nucleic acids encoding the antibodies, vectors and host cells comprising the nucleic acids, and methods of making and using the antibodies.

Abstract: The present disclosure relates to compositions comprising preparations of uncultured fecal bacteria, methods of manufacturing the compositions, and methods of using the compositions to treat a disorder related to a gut dysbiosis.

Abstract: An example of a system for post-case analysis of cardiopulmonary resuscitation (CPR) performance trends includes a ventilation metrics device with sensors configured to generate signals indicative of ventilation treatment data during a medical treatment of a patient, and a patient monitor/defibrillator configured to receive the signals, calculate the ventilation treatment data based on the received signals, and transmit the ventilation treatment data, and a remote computing device configured to communicatively couple with the treatment monitoring system and with an output display device, the computing device including at least one memory and at least one processor communicatively coupled to the memory, the at least one processor configured to receive treatment data from the treatment monitoring system, the treatment data including the ventilation treatment data, and provide case review information at a case review dashboard at the output device, the case review information including time trend plots of the ve

Abstract: A damping control system for a vehicle having a suspension located between a plurality of ground engaging members and a vehicle frame includes at least one adjustable shock absorber having an adjustable damping profile.

Abstract: The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A product including a previously unopened closed container and a plurality of cleaning wipes contained in the container. The cleaning wipes include a first nonwoven having a plurality of first nonwoven strips and a second nonwoven having a plurality of second nonwoven strips. More than about 10% of the second nonwoven strips are bent so that the free ends of the second nonwoven strips are bent out of plane relative to the fixed ends of the second nonwoven strips.

Abstract: A cleaning wipe including a first nonwoven having a plurality of first nonwoven strips and a second nonwoven having a plurality of second nonwoven strips. The first nonwoven and the second nonwoven are each gate folded. More than about 10% of the second nonwoven strips are bent so that the free ends of the second nonwoven strips are bent out of plane relative to the fixed ends of the second nonwoven strips.

Abstract: A cleaning wipe including a first nonwoven having a plurality of first nonwoven strips, a second nonwoven having a plurality of second nonwoven strips, a third nonwoven having a plurality of third nonwoven strips, and a fourth nonwoven having a plurality of fourth nonwoven strips. The cleaning wipe includes a central bonded portion and the fourth nonwoven is further joined to the third nonwoven by a pair of outboard bonds. More than about 10% of the second nonwoven strips are bent so that the free ends of the second nonwoven strips are bent out of plane relative to the fixed ends of the second nonwoven strips.

Abstract: A process for packaging a product including the steps of providing a cleaning wipe that includes nonwoven strips and moving the cleaning wipe in a direction aligned with the longitudinal axis of the cleaning wipe. A gas is moved from positions on opposite sides of the longitudinal axis and beyond the longitudinal edges of the cleaning wipe to bend the free ends of the nonwoven strips out of plane relative to the fixed ends of the strips.

Abstract: Described are effervescent dissolvable solid structures comprising effervescent agglomerated particles which enhance the consumer experience and can improve dissolution of the structure. Also described are processes for the Dissolvable Solid Structure comprising effervescent agglomerated particles. Also described are methods for making the effervescent agglomerated particle.

Abstract: Embodiments are disclosed for generating an intelligent change summary are described. In some embodiments, a method of generating an intelligent change summary includes obtaining a representation of a plurality of versions of a document, determining a distance score based on a comparison of a first of version of the document and a second version of the document, the distance score representing a magnitude of changes made from the first version of the document to the second version of the document, and generating a change summary of the document based on the distance score.

Abstract: Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Abstract: The disclosed embodiments include a system and method for generating a predictive model for determining whether a reamer has experienced significant wear. The system includes an information acquisition processor and a server. The information acquisition processor retrieves wellbore information, transmits the information to the server.

Abstract: This invention discloses a medicinal composition includes a non-coding RNA molecule and an antibody targeting a tumor antigen for preventing and/or treating cancer. This invention uses the synergistic combination of a non-coding RNA molecule or its functional variant or homologue, and an antibody targeting a tumor antigen to prevent and/or treat cancer, thereby providing a novel and effective method in preventing and/or treating various cancers.

Abstract: A ladder rack system may have a slide with a support flange and a spanning flange. The system may also have a ladder support member adapted to selectively receive a portion of the support flange therein. The system may also have a pivot bracket pivotally connected to the ladder support member. The pivot bracket may be adapted to selectively move the ladder support member.

Abstract: A dialysis system includes a fluidics system configured to perform a dialysis treatment session for a patient by having sensor(s) that measure corresponding parameter(s) and having dialysis actuator(s) that configures fluid flow through the fluidics system. The dialysis system includes a communication subsystem configured to communicatively connect to user device(s). A controller of the dialysis system is communicatively coupled to the fluidics system and the communication subsystem. The controller operates the fluidics system to perform the dialysis treatment session. The controller maintains data associated with the fluidics system. The data includes data types of patient health information, de-identified health information; and non-health information. The controller identifies access rights associated with first credential used by a first user device to the data types and communicates the data types to the first user device according to the access rights.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: An appliance includes a cabinet, defining a food storage chamber, and a door. The appliance includes a hinge system coupling the door to the cabinet. The hinge system includes a first hinge arm fixed to the door, a second hinge arm pivotably joined with the first hinge arm, a carrier fixed to the cabinet, the second hinge arm releasably received in the carrier, and a tether cable extending between a first end and a second end. The first end of the tether cable fixed to the second hinge arm, the second end of the tether cable removably attached to a surface inside the food storage chamber. The tether cable configured such that the door may be detachable from the cabinet when the second end of the tether cable becomes detached from the surface inside the food storage chamber.

Abstract: A reusable decorative ornament for use on wrapping paper or the like includes an ornamental element such as a ribbon flower or bow. The ornament includes an attachment element for securing the ornament to wrapping paper. The attachment element includes a stack of adhesive elements. By selectively exposing an adhesive layer, the decorative ornament can be used multiple times. The adhesive elements may be secured to the ornament element by a fixed device such as a staple. Each adhesive layer may include a fixed portion in the area of the staple. Perforations may divide the fixed portion from a removable portion of the layer to facilitate easy removal and reuse of the decorative ornament.