Abstract: Systems and methods for generating an electromechanical map are disclosed herein. The methods includes obtaining ultrasound data comprising a series of consecutive image frames and radio frequency (RF) signals corresponding to the location in the heart; measuring displacements and strains based on the ultrasound data to determine an electromechanical activation in the location; converting the ultrasound data into a series of isochrone maps; and combining the series of isochrone maps to generate the electromechanical map. The electromechanical map illustrates the electromechanical activation and internal wall structures of the heart.

Abstract: System and methods for monitoring cardiac ablation procedures are disclosed. The system can comprise an imaging device and an image processor. The imaging device can be configured to acquire successive frames and radio frequency signal data of a heart. The image process, coupled to the imaging device, can be configured to obtain a signal envelope of the radio frequency signal data, generate a strain map based on the signal envelope, apply a strain threshold to the strain map for classification of lesion tissue, and provide an image which visualizes lesion formation during the cardiac ablation procedures in real-time.

Abstract: Systems and methods for generating an electromechanical map are disclosed herein. The methods includes obtaining ultrasound data comprising a series of consecutive image frames and radio frequency (RF) signals corresponding to the location in the heart; measuring displacements and strains based on the ultrasound data to determine an electromechanical activation in the location; converting the ultrasound data into a series of isochrone maps; and combining the series of isochrone maps to generate the electromechanical map. The electromechanical map illustrates the electromechanical activation and internal wall structures of the heart.

Abstract: Techniques for mapping behavior of a heart include acquiring a series of two or more images of the heart. The series of images is taken at one or more pixel locations, each pixel location corresponding to a region of the heart. Image data corresponding to the pixel locations can be obtained, and a periodicity of the image data measured for each of the pixel locations over the series of images. The periodicity corresponds to an electromechanical signal of the heart in the region corresponding to the measured one or more pixel locations.

Abstract: Techniques for mapping behavior of a heart include acquiring a series of two or more images of the heart. The series of images is taken at one or more pixel locations, each pixel location corresponding to a region of the heart. Image data corresponding to the pixel locations can be obtained, and a periodicity of the image data measured for each of the pixel locations over the series of images. The periodicity corresponds to an electromechanical signal of the heart in the region corresponding to the measured one or more pixel locations.

Abstract: The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided. Methods and kits for treating or ameliorating the effects of heart failure syndrome, high blood pressure and diabetes also are provided. Methods, kits and compositions which include compounds of the present invention also are provided.

Abstract: Techniques for mapping behavior of a heart include acquiring a series of two or more images of the heart. The series of images is taken at one or more pixel locations, each pixel location corresponding to a region of the heart. Image data corresponding to the pixel locations can be obtained, and a periodicity of the image data measured for each of the pixel locations over the series of images. The periodicity corresponds to an electromechanical signal of the heart in the region corresponding to the measured one or more pixel locations.

Abstract: A system for manufacturing a product receives a formulation specification that includes a plurality of ingredients for the product. The system further receives cost information for the ingredients and inventory information. The system then generates a least cost formulation for the product based on the formulation specification, cost information and inventory information.

Abstract: A system that determines product quantities for a process manufacturing formula that generates a first product and a second product receives a quantity of a first ingredient and a quantity of a second ingredient. The first and second ingredients contribute to a formula yield. The system further receives a quantity of a byproduct of the formula and a percentage of the formula for the output first product and a percentage of the formula for the output second product. The system then automatically determines a first product quantity based on the quantity of the first ingredient, the quantity of the second ingredient, the quantity of the byproduct of the formula, and the percentage of the formula for the first product.

Abstract: A system for manufacturing a product receives a formulation specification that includes a plurality of ingredients for the product. The system further receives cost information for the ingredients and inventory information. The system then generates a least cost formulation for the product based on the formulation specification, cost information and inventory information.

Abstract: A computer implemented method for managing a stability or shelf life study is provided. Requirements for a stage in a plurality of stages are determined and interfaces are output that define the requirements. Information may then be input for fulfilling the requirements. The input information is then validated against business rules that define logic to determine if the input information is acceptable. The input information is then stored.