Abstract: Methods and compositions are provided for treating inflammatory-related diseases and related disorders in a mammalian subject. The method provides administering to the mammalian subject one or more modulators of cyclin dependent kinase 4 (Cdk4) activity in an amount effective to reduce or eliminate the inflammatory-related disease or disorder or prevent its occurrence or recurrence. Methods are also provided for reducing or eliminating ligand-induced adhesion in a mammalian subject. The method provides administering to the subject one or more modulators of cyclin dependent kinase 4 (Cdk4) activity in an amount effective to reduce or eliminate ligand-induced adhesion.

Abstract: A game board defining a playing surface that has a plurality of box-like spaces. The box-like spaces have a color and numerical indicia printed thereon. Each box-like space is adjacent at least one other box-like space. Included are a plurality of red chips that have a top side and a bottom side. The red chips are positionable on the box-like spaces of the game board. A plurality of blue chips are included. The blue chips have a top side and a bottom side and are positionable on the box-like spaces of the game board. Lastly, two decks of playing cards are provided. Each deck consisting of a plurality of cards that have an underside. One of the cards of the plurality of cards is pulled from one of the decks of cards. The underside of some of the cards have numerical indicia thereon for matching the numerical indicia on the game board to initiate placement of one of the red or blues chips on the box-like spaces.