Patents by Inventor Elaine Y. Lai

Elaine Y. Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing apoptosis by reducing the level of thiamin
    Patent number: 7803531
    Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: September 28, 2010
    Assignee: Brandeis University
    Inventors: Chandler Fulton, Elaine Y. Lai
  • Thiaminases and thiaminase genes for use in apoptotic therapies
    Patent number: 7736898
    Abstract: This disclosure describes methods for preparing and utilizing thiaminase and thiaminase genes to induce apoptosis in a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Emphasis is on methods for inducing apoptosis in cancer cells.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: June 15, 2010
    Assignee: Brandeis University
    Inventors: Chandler Fulton, Elaine Y. Lai
  • Method of inducing apoptosis by reducing the level of thiamin
    Publication number: 20040013658
    Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
    Type: Application
    Filed: January 13, 2003
    Publication date: January 22, 2004
    Applicant: Brandeis University
    Inventors: Chandler Fulton, Elaine Y. Lai
  • Method of including apoptosis by reducing the level of thiamin
    Patent number: 6506550
    Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: January 14, 2003
    Assignee: Brandeis University
    Inventors: Chandler Fulton, Elaine Y. Lai