Patents by Inventor Elazar Rabbani

Elazar Rabbani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for detecting or quantifying more than one nucleic acid in a library
    Patent number: 9528146
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: December 27, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • Method for treating crohn'S disease or ulcerative colitis by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
    Patent number: 9492419
    Abstract: The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: November 15, 2016
    Assignee: Enzo Biochem, Inc.
    Inventors: Elazar Rabbani, Xiaofeng Li, Dakai Liu, Yazhou Zhang, Richard Jin, Riddhi Bhattacharyya, Wei Cheng, James J. Donegan
  • Composition comprising library of double stranded nucleic acids
    Patent number: 9487821
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: November 8, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • ASSAYS FOR DETECTING MODIFIED COMPOUNDS
    Publication number: 20160305949
    Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
    Type: Application
    Filed: June 28, 2016
    Publication date: October 20, 2016
    Applicant: Enzo Life Sciences, Inc. c/o Enzo Biochem
    Inventors: Elazar RABBANI, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
  • TOLERIZING TREATMENTS FOR AUTOIMMUNE DISEASE
    Publication number: 20160296565
    Abstract: The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
    Type: Application
    Filed: June 22, 2016
    Publication date: October 13, 2016
    Applicant: Enzo Biochem, Inc.
    Inventors: Robert Nussenblatt, Baoying Liu, Lai Wei, Elazar Rabbani, James J. Donegan
  • OPTIMIZED REAL TIME NUCLEIC ACID DETECTION PROCESSES
    Publication number: 20160281146
    Abstract: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided. Paneling and multiplex analyses of more than one nucleic acid analyte using one sample are also provided.
    Type: Application
    Filed: March 30, 2016
    Publication date: September 29, 2016
    Applicant: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, James J. Donegan, Dakai Liu
  • PROCESSES FOR QUANTITATIVE OR QUALITATIVE DETECTION OF SINGLE-STRANDED OR DOUBLE-STRANDED NUCLEIC ACIDS
    Publication number: 20160273028
    Abstract: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 22, 2016
    Applicant: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman, Dakai Liu
  • Composition comprising an array which further comprises chimeric compositions
    Patent number: 9434984
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: September 6, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • Nucleic acid detecting or quantifying processes
    Patent number: 9428797
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: August 30, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • Assays for detecting modified compounds
    Patent number: 9404143
    Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: August 2, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Joshua Rabbani, Praveen Pande, Jannis G. Stavrianopoulos
  • PROCESSES FOR DETECTING OR QUANTIFYING MORE THAN ONE NUCLEIC ACID IN A LIBRARY
    Publication number: 20160208320
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 21, 2016
    Applicant: Enzo Biochem, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • PROCESSES FOR DETECTING OR QUANTIFYING NUCLEIC ACIDS IN A LIBRARY
    Publication number: 20160194693
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 7, 2016
    Applicant: Enzo Biochem, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • PROCESS FOR DETECTING OR QUANTIFYING NUCLEIC ACIDS IN A LIBRARY
    Publication number: 20160186246
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Application
    Filed: July 29, 2015
    Publication date: June 30, 2016
    Applicant: Enzo Biochem, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • COMPREHENSIVE AND COMPARATIVE FLOW CYTOMETRY-BASED METHODS FOR IDENTIFYING THE STATE OF A BIOLOGICAL SYSTEM
    Publication number: 20160177396
    Abstract: The present disclosure provides comprehensive and comparative flow cytometry-based methods for identifying the state of a biological system by identifying the phenotype of cells and correlating the phenotype with the gene expression profile of the cells, which is indicative of cell function. The cells can be immune cells from a subject suffering from immune-mediated disorders that result in imbalance of the immune system and impair a subject's ability to recognize self-antigens or fight infection or disease. In certain aspects, cell phenotype is identified by detecting and/or quantifying one or more markers on the cell surface or intracellularly, which readily enables identification of specific sub-types of cells of interest, which can then be analyzed for gene expression in order to assay cell function.
    Type: Application
    Filed: February 2, 2015
    Publication date: June 23, 2016
    Applicant: Enzo Biochem, Inc.
    Inventors: Elazar Rabbani, James J. Donegan, Andrew Stewart L'Huillier
  • Optimized real time nucleic acid detection processes
    Patent number: 9353405
    Abstract: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided. Paneling and multiplex analyzes of more than one nucleic acid analyte using one sample are also provided.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: May 31, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, James J. Donegan, Dakai Liu
  • Fluorochromes for organelle tracing and multi-color imaging
    Patent number: 9334281
    Abstract: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: May 10, 2016
    Assignee: ENZO LIFE SCIENCES, INC.
    Inventors: Wayne Forrest Patton, Praveen Pande, Yuejun Xiang, Zaiguo Li, James J. Donegan, Elazar Rabbani
  • Processes for quantitative or qualitative detection of single-stranded or double-stranded nucleic acids
    Patent number: 9316587
    Abstract: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: April 19, 2016
    Assignee: Enzo LIfe Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman, Dakai Liu
  • Compositions and processes for analyte detection, quantification and amplification
    Patent number: 9309563
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: April 12, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • Processes for detecting or quantifying analytes of interest
    Patent number: 9279147
    Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: March 8, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman
  • Real-time nucleic acid detection processes and compositions
    Patent number: 9261460
    Abstract: This invention provides compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: February 16, 2016
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Jack Coleman, Dakai Liu