Patents by Inventor Eldad Klaiman

Eldad Klaiman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220237788
    Abstract: The method includes, for each of a plurality of tiles of an image, extracting a feature vector from the tile; providing a Multiple-Instance-Learning program configured to use a model for classifying any input image as a member of one out of at least two different classes based on feature vectors extracted from the tiles; for each of the tiles, computing a certainty value indicating the certainty of the model regarding the contribution of the tile's feature vector on the classification of the image; for each of the images, using, by the MIL-program, a certainty-value-based pooling function for aggregating the feature vectors of the image or predictive values computed from the feature vectors of the image into an aggregated predictive value as a function of the certainty values of the tiles; and classifying each of the images as a member of one of the classes based on the aggregated predictive value.
    Type: Application
    Filed: March 30, 2022
    Publication date: July 28, 2022
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Ido Ben SHAUL, Jacob GILDENBLAT, Eldad KLAIMAN
  • Patent number: 11385179
    Abstract: The method includes receiving a digital image of a slide, the slide including the tissue sample, a target dot and a fluoro dot. The digital image includes intensity values of the tissue sample, the target dot and the fluoro dot. The method further includes receiving pixel intensities of the fluoro dot depicted in the image; pixel intensities of the target dot depicted in the image; pixel intensities of an area of the tissue sample depicted in the image; fluorescence-inducing molecule density information indicative of the known density of the fluorescence-inducing molecules in the fluoro dot; target molecule density information indicative of the known density of the target molecules in the target dot; and computing the density of target molecules in the area of the tissue sample as a function of the received pixel intensities and the received molecule density information.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: July 12, 2022
    Assignee: HOFFMANN-LA ROCHE, INC.
    Inventor: Eldad Klaiman
  • Publication number: 20220139072
    Abstract: The method includes receiving a plurality of digital images each depicting a tissue sample; splitting each of the received images into a plurality of tiles; automatically generating tile pairs, each tile pair having assigned a label being indicative of the degree of similarity of two tissue patterns depicted in the two tiles of the pair, wherein the degree of similarity is computed as a function of the spatial proximity of the two tiles in the pair, wherein the distance positively correlates with dissimilarity; and training a machine learning module—MLM—using the labeled tile pairs as training data to generate a trained MLM, the trained MLM being configured for performing an image analysis of digital histopathology images.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 5, 2022
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Eldad KLAIMAN, Jacob GILDENBLAT
  • Patent number: 11315240
    Abstract: At least one embodiment relates to an image analysis system for tumor classification. The system is configured for receiving at least one digital image of a tissue sample; analyzing the at least one received image for identifying immune cells and tumor cells in the at least one received image; for each of the identified tumor cells, determining the distance of the tumor cell to the nearest immune cell; computing a proximity measure as a function of the determined distances; in dependence on the proximity measure, classifying the identified tumor cells into tumor cells of an inflammatory tumor or as tumor cells of a non-inflammatory tumor; and storing the classification result on a storage medium and/or displaying the classification result on a display device.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: April 26, 2022
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Fabien Gaire, Eldad Klaiman, Konstanty Korski
  • Publication number: 20220031270
    Abstract: Apparatus and methods are described for use with a tool that is inserted into a portion of a body of a subject that undergoes cyclic motion. The apparatus and methods include using an imaging device, acquiring a plurality of images of the tool inside the portion of the body, at respective phases of the cyclic motion. Using at least one computer processor, an extent of movement of the tool with respect to the portion of the body that is due to the cyclic motion of the portion of the body is determined. In response thereto, an output is generated that is indicative of the determined extent of the movement of the tool with respect to the portion of the body. Other applications are also described.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 3, 2022
    Inventors: Ran COHEN, Zohar BARZELAY, Eldad KLAIMAN, ALexander STEINBERG
  • Patent number: 11197651
    Abstract: Apparatus and methods are described for use with a tool that is inserted into a portion of a body of a subject that undergoes cyclic motion. The apparatus and methods include using an imaging device, acquiring a plurality of images of the tool inside the portion of the body, at respective phases of the cyclic motion. Using at least one computer processor, an extent of movement of the tool with respect to the portion of the body that is due to the cyclic motion of the portion of the body is determined. In response thereto, an output is generated that is indicative of the determined extent of the movement of the tool with respect to the portion of the body. Other applications are also described.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: December 14, 2021
    Assignee: SYNC-RX, LTD.
    Inventors: Ran Cohen, Zohar Barzelay, Eldad Klaiman, Alexander Steinberg
  • Patent number: 11179038
    Abstract: Apparatus and methods are described for imaging a tool inside a portion of a subject's body that undergoes motion. A plurality of image frames are acquired of the portion of the subject's body. The image frames are image tracked by (a) automatically identifying at least a feature of the tool in at least a portion of the image frames, and (b) aligning the tool in image frames of the portion of the image frames, based on the automatic identifying. The image-tracked image frames of the portion of the subject's body are displayed as an image stream. Other embodiments are also described.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: November 23, 2021
    Assignee: SYNC-RX, LTD
    Inventors: Eldad Klaiman, Alexander Steinberg, Ran Cohen, David Tolkowsky
  • Publication number: 20210350176
    Abstract: The method includes receiving digital images of tissue samples of patients, the images having assigned a label indicating a patient-related attribute value; splitting each received image into a set of image tiles; computing a feature vector for each tile; training a Multiple-Instance-Learning program on all the tiles and respective feature vectors for computing for each of the tiles a numerical value being indicative of the predictive power of the feature vector associated with the tile in respect to the label of the tile's respective image; and outputting a report gallery including tiles sorted in accordance with their respectively computed numerical value and/or including a graphical representation of the numerical value.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 11, 2021
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Eldad KLAIMAN, Jacob GILDENBLAT
  • Publication number: 20210338186
    Abstract: Apparatus and methods are described for use with an imaging device (12) configured to acquire a set of angiographic images of a lumen. At least one processor (10) includes blood-velocity-determination functionality (16) that determines blood velocity within the lumen, via image processing. Current-flow-related-parameter-determination functionality (18) determines a value of a flow-related parameter at the location based upon the determined blood velocity. Flow-related-parameter-receiving functionality (19) receives an indication of a value of a second flow-related parameter of the subject, and index-determination functionality (21) determines a value of a luminal-flow-related index of the subject at the location, by determining a relationship between the value of the current flow-related parameter and the value of the second flow-related parameter. Other applications are also described.
    Type: Application
    Filed: July 16, 2021
    Publication date: November 4, 2021
    Inventors: David TOLKOWSKY, Alexander STEINBERG, Eldad KLAIMAN, Ran COHEN
  • Publication number: 20210338097
    Abstract: Apparatus and methods are described including a processor (20) configured to receive first and second sets of extraluminal images of a lumen, the second set being acquired while an endoluminal device is being moved through the lumen. The processor designates at least one of the first set of images as a roadmap image, and designates, within the lumen in the roadmap image, a roadmap pathway (42). A plurality of features (44, 46, 48, 50) that are visible within at least some of the second set of extraluminal images are identified, and an arrangement of three or more of the features within the image are compared to a shape of at least a portion of the roadmap pathway. Based upon the comparing, the identified features are mapped to locations along the roadmap pathway within the roadmap image. Other applications are also described.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 4, 2021
    Inventors: Alexander STEINBERG, Eldad KLAIMAN, Zohar BARZELAY, Ran COHEN, David TOLKOWSKY
  • Patent number: 11064903
    Abstract: Apparatus and methods are described including a processor (20) configured to receive first and second sets of extraluminal images of a lumen, the second set being acquired while an endoluminal device is being moved through the lumen. The processor designates at least one of the first set of images as a roadmap image, and designates, within the lumen in the roadmap image, a roadmap pathway (42). A plurality of features (44, 46, 48, 50) that are visible within at least some of the second set of extraluminal images are identified, and an arrangement of three or more of the features within the image are compared to a shape of at least a portion of the roadmap pathway. Based upon the comparing, the identified features are mapped to locations along the roadmap pathway within the roadmap image. Other applications are also described.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: July 20, 2021
    Assignee: SYNC-RX, LTD
    Inventors: Alexander Steinberg, Eldad Klaiman, Zohar Barzelay, Ran Cohen, David Tolkowsky
  • Patent number: 11064964
    Abstract: Apparatus and methods are described for use with a plurality of angiographic image frames of a moving lumen of a subject, including aligning the image frames with each other. Using the aligned image frames, a time it takes a contrast agent to travel a known distance through the lumen is determined. At least partially in response thereto, a characteristic of the lumen is determined, and, in response to the determined characteristic, an output is generated on a display. Other applications are also described.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: July 20, 2021
    Assignee: SYNC-RX, LTD
    Inventors: David Tolkowsky, Alexander Steinberg, Eldad Klaiman, Ran Cohen
  • Publication number: 20210158519
    Abstract: Apparatus and methods are described including, using a computer processor, automatically identifying whether a given pixel within an image corresponds to a portion of an object. A set of concentric circles that are disposed around the pixel are sampled, and a first function is applied to each of the circles such that the circles are defined by a first set of rotationally invariant descriptors. A second function is applied to the set of circles to generate a second set of descriptors, each of which represents a difference between respective pairs of the circles. A third function is applied such that the second set of descriptors becomes rotationally invariant. The processor identifies whether the given pixel corresponds to the portion of the object, based upon the first and second sets of rotationally invariant descriptors. Other applications are also described.
    Type: Application
    Filed: February 5, 2021
    Publication date: May 27, 2021
    Inventors: Eldad KLAIMAN, Alexander STEINBERG, Nili KARMON, Sarit SEMO, Ran COHEN
  • Patent number: 10984531
    Abstract: Apparatus and methods are described for use with an imaging device (12) configured to acquire a set of angiographic images of a lumen. At least one processor (10) determines blood velocity within the lumen, via image processing. The processor determines a value of a flow-related parameter at the location based upon the determined blood velocity. The processor additionally receives an indication of a value of a second flow-related parameter of the subject, and determines a value of a luminal-flow-related index of the subject at the location, by determining a relationship between the value of the current flow-related parameter and the value of the second flow-related parameter. Other applications are also described.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: April 20, 2021
    Assignee: SYNC-RX, LTD.
    Inventors: Eldad Klaiman, Ran Cohen, David Tolkowsky, Alexander Steinberg
  • Patent number: 10916009
    Abstract: Apparatus and methods are described including, using a computer processor (28), automatically identifying whether a given pixel (111) within an image corresponds to a portion of an object. A set of concentric circles (132a-c) that are disposed around the pixel are sampled, and a first function is applied to each of the circles such that the circles are defined by a first set of rotationally invariant descriptors. A second function is applied to the set of circles to generate a second set of descriptors, each of which represents a difference between respective pairs of the circles. A third function is applied such that the second set of descriptors becomes rotationally invariant. The processor identifies whether the given pixel corresponds to the portion of the object, based upon the first and second sets of rotationally invariant descriptors. Other applications are also described.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: February 9, 2021
    Assignee: SYNC-RX LTD.
    Inventors: Eldad Klaiman, Alexander Steinbert, Nili Karmon, Sarit Semo, Ran Cohen
  • Publication number: 20210005308
    Abstract: The invention relates to a method of identifying a biomarker in a tissue sample. The method comprises receiving an acquired image depicting a tissue sample, the pixel intensity values of the acquired image correlating with an autofluorescence signal or of an X-ray induced signal or a signal of a non-biomarker specific stain or a signal of a first biomarker specific stain adapted to selectively stain a first biomarker. The acquired image is input into a trained machine learning logic—MLL which automatically transforms the acquired image into an output image highlighting tissue regions predicted to comprise a second biomarker.
    Type: Application
    Filed: July 31, 2020
    Publication date: January 7, 2021
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventor: Eldad KLAIMAN
  • Patent number: 10846848
    Abstract: An image processing system configured to receive a first fluorescence image generically indicating the presence of biological matter; transform the first image into a transformed first image having a first color; for each of the biomarkers, receive a respective second fluorescence image indicating signals emitted by fluorescence stain selectively staining the biomarker, transforming the second images into a respective transformed second images having a respective second color; overlaying and combining the transformed first and second images; storing and/or displaying the combined image as the simulated digital bright field IHC or ISH image. The first image is created using an autofluorescence reference spectrum of the tissue sample or of a similar tissue sample or by using a fluorescence reference spectrum of a first stain which generically binds to biological matter of the tissue sample for spectrally unmixing of a multi-spectral digital image of the tissue sample.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: November 24, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventor: Eldad Klaiman
  • Publication number: 20200345321
    Abstract: Apparatus and methods are provided for use with an endoluminal data-acquisition device that acquires a set of endoluminal data-points of a lumen of a subject's body at respective locations inside the lumen, a second endoluminal device, and a display configured to display images. At least one processor includes location-association functionality that associates a given data point acquired by the endoluminal data-acquisition device with a given location within the lumen. Location-determination functionality determines, by means of image processing, in an extraluminal image of the second endoluminal device, a current location of at least a portion of the second endoluminal device. Display-driving functionality drives the display to display an indication of the endoluminal data point associated with the location, in response to determining that the portion of the second device is currently at the location. Other applications are also described.
    Type: Application
    Filed: July 15, 2020
    Publication date: November 5, 2020
    Inventors: David TOLKOWSKY, Ran COHEN, Eldad KLAIMAN
  • Publication number: 20200327657
    Abstract: An image processing system configured to receive a first fluorescence image generically indicating the presence of biological matter; transform the first image into a transformed first image having a first color; for each of the biomarkers, receive a respective second fluorescence image indicating signals emitted by fluorescence stain selectively staining the biomarker, transforming the second images into a respective transformed second images having a respective second color; overlaying and combining the transformed first and second images; storing and/or displaying the combined image as the simulated digital bright field IHC or ISH image. The first image is created using an autofluorescence reference spectrum of the tissue sample or of a similar tissue sample or by using a fluorescence reference spectrum of a first stain which generically binds to biological matter of the tissue sample for spectrally unmixing of a multi-spectral digital image of the tissue sample.
    Type: Application
    Filed: June 9, 2017
    Publication date: October 15, 2020
    Inventor: Eldad KLAIMAN
  • Publication number: 20200279354
    Abstract: The invention relates to a digital pathology method of generating program logic configured for removing artifacts from digital tissue images. The method comprises generating, for each of a plurality of original images, a first artificially degraded image by applying a first image-artifact-generation logic on each of the original images; and generating the program logic by training an untrained version of a first machine-learning logic that encodes a first artifacts-removal logic on the original images and their respectively generated first degraded images; and returning the trained first machine-learning logic as the program logic or as a component thereof. The first image-artifact-generation logic is A) an image-acquisition-system-specific image-artifact-generation logic or B) a tissue-staining-artifact-generation logic.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 3, 2020
    Applicant: HOFFMANN-LA ROCHE INC
    Inventor: Eldad KLAIMAN