Patents by Inventor Eldon E. Baird

Eldon E. Baird has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090247513
    Abstract: Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.
    Type: Application
    Filed: December 4, 2007
    Publication date: October 1, 2009
    Applicant: GeneSoft Pharmaceuticals, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Patent number: 7498405
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: March 3, 2009
    Assignee: GeneSoft Pharmaceuticals, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Roland W. Burli, Jacob A. Kaizerman, Amanda E. Martin, Brie Cadman
  • Patent number: 7498349
    Abstract: Aromatic compounds exemplified by exhibit antimicrobial activity.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: March 3, 2009
    Assignee: Genesoft Pharmaceuticals, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Jacob A. Kaizerman, Dustin L. McMinn
  • Patent number: 7329765
    Abstract: Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: February 12, 2008
    Assignee: GeneSoft Pharmaceuticals, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Patent number: 7301037
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: November 27, 2007
    Assignee: Genesoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Burli
  • Patent number: 7122626
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: October 17, 2006
    Assignee: GeneSoft Pharmceuticals, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Roland W. Bürli, Jacob A. Kaizerman, Amanda E. Martin, Brie Cadman
  • Patent number: 7087378
    Abstract: The invention encompasses improved selective polyamides for binding to specific nucleotide sequences of double stranded DNA as well as methods for designing and synthesizing polyamide DNA binding ligands that are selective for an identified specific nucleotide sequence. The 3-hydroxy-N-methylpyrrole/N-methylpyrrole carboxamide pair specifically recognizes the T•A base pair, while the N-methylpyrrole/3-hydroxy-N-methylpyrrole pair recognizes A•T nucleotide pairs. Similarly, an N-methylimidizole/N-methylpyrrole carboxamide pair specifically recognizes the G•C nucleotide pair, and the N-methylpyrrole/N-methylimidizole carboxamide pair recognizes the C•G nucleotide pair.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: August 8, 2006
    Assignee: California Institute of Technology
    Inventors: Eldon E. Baird, Peter B. Dervan
  • Patent number: 7078536
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: July 18, 2006
    Assignee: Genesoft Pharmaceuticals, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Bürli
  • Patent number: 7049061
    Abstract: This invention provides improved polyamides comprising a hairpin loop derived from ?-aminobutyric acid which bind to the minor groove of a promoter regions of a DNA sequence. Binding of the polyamide to the DNA sequence of the promoter region inhibits expression of the requisite gene. The improvement relates to the use of R-2,4-diaminobutyric acid and derivatives of the 2-amino group to form the hairpin loop. The improved asymmetric hairpin provides for tighter binding of the polyamides to the minor groove of DNA and additionally provides an amine function for derivatizing polyamides by, for example, forming amide linkages. Such derivatives may serve to attach detectable labels to the polyamide.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: May 23, 2006
    Assignee: California Institute of Technology
    Inventors: Eldon E. Baird, Peter B. Dervan
  • Patent number: 6958240
    Abstract: This invention provides improved polyamides comprising a positive patch for contacting the phosphate backbone or major groove of a DNA molecule. As such, the improved polyamides are capable of inhibiting the function or binding of a DNA-binding protein to a DNA molecule. The improved polyamide provides for more efficient function of the polyamide.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: October 25, 2005
    Assignee: California Instiute of Technology
    Inventors: Eldon E. Baird, Peter B. Dervan
  • Patent number: 6825228
    Abstract: Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: November 30, 2004
    Assignee: Genesoft Pharmaceuticals, Inc.
    Inventors: Roland W. Bürli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Publication number: 20040142971
    Abstract: Benzothiophene compounds such as 1
    Type: Application
    Filed: June 6, 2002
    Publication date: July 22, 2004
    Applicant: GeneSoft, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Patent number: 6716866
    Abstract: Aryl-benzimidazole compounds according to the formula where Ar1, R1, R2, Y, W, and N are as defined herein, bind to DNA and have antibacterial activity.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: April 6, 2004
    Assignee: GeneSoft Pharmaceuticals, Inc.
    Inventors: Dustin L. McMinn, Roland W. Bürli, Jacob Kaizerman, Eldon E. Baird, Matthew J. Taylor
  • Patent number: 6673940
    Abstract: The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: January 6, 2004
    Assignee: California Institute of Technology
    Inventors: Peter B. Dervan, Eldon E. Baird
  • Patent number: 6660255
    Abstract: The invention provides polyamides suitable for modulating cellular or viral gene expression by binding to an identified target DNA sequence adjacent to the binding site of a minor groove transcription factor protein. The polyamides of the present invention are useful for the treatment of a human infected with a virus such as HIV-1. The polyamides of the present invention are also useful for the treatment of conditions, such as cancers, that result from the expression or over-expression of cellular genes, particularly oncogenes.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: December 9, 2003
    Assignees: California Institute of Technology, The Scripps Research Institute
    Inventors: Joel M. Gottesfeld, Peter B. Dervan, Donald E. Mosier, Eldon E. Baird
  • Publication number: 20030211508
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Application
    Filed: October 22, 2002
    Publication date: November 13, 2003
    Applicant: Genesoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Burli
  • Publication number: 20030199516
    Abstract: Methods are provided for treating an infection by Gram-positive bacteria in a mammal, by administering to the mammal an effective amount of a compound that binds noncovalently in the minor groove of duplex DNA, the compound being identified by a number of DNA binding parameters and, in many instances, being a polyaromatic compound.
    Type: Application
    Filed: September 12, 2002
    Publication date: October 23, 2003
    Applicant: Genesoft, Inc.
    Inventors: Heinz E. Moser, Eldon E. Baird, Roland W. Burli, Yigong Ge, Sarah White
  • Publication number: 20030191168
    Abstract: Aryl-benzimidazole compounds according to the formula 1
    Type: Application
    Filed: June 6, 2002
    Publication date: October 9, 2003
    Applicant: GeneSoft, Inc.
    Inventors: Dustin L. McMinn, Roland W. Burli, Jacob Kaizerman, Eldon E. Baird, Matthew J. Taylor
  • Publication number: 20030130198
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Application
    Filed: April 24, 2002
    Publication date: July 10, 2003
    Applicant: GeneSoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Roland W. Burli, Jacob A. Kaizerman, Amanda E. Martin, Brie Cadman
  • Patent number: 6555693
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: April 29, 2003
    Assignee: Genesoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Bürli