Patents by Inventor Eleanor B. McGowan

Eleanor B. McGowan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bifunctional energy-reversible acyl-compositions
    Patent number: 7449315
    Abstract: Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: November 11, 2008
    Assignee: Cryolife, Inc.
    Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
  • Bifunctional energy-reversible acyl-compositions
    Patent number: 7157458
    Abstract: Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: January 2, 2007
    Assignee: Cryolife, Inc.
    Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
  • Prodrugs via acylation with cinnamate
    Patent number: 6774116
    Abstract: A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically withdrawing groups to modify the cinnamate moiety's electric properties as well as photo reactivities for the purpose of achieving a proper hydrolysis rate of the acyl bond between the biologically active molecule moiety and the cinnamic acid backbone. The biologically active molecule can be any biologically active agent or diagnostic, for example, a chemotherapeutic such as a paclitaxel, campotothecin, doxorubicin, amethopterin, etoposide, or fluconazole. The prodrug composition can be modified to add a carrier moiety on the prodrug composition for targeting or to facilitate uptake of the drug. The prodrug compositions can be activated with an energy source to release the drug at the desired site.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: August 10, 2004
    Assignee: Cryolife, Inc.
    Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
  • Bifunctional energy-reversible acyl-compositions
    Publication number: 20020187993
    Abstract: Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed.
    Type: Application
    Filed: January 31, 2002
    Publication date: December 12, 2002
    Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
  • Prodrugs via acylation with cinnamate
    Publication number: 20020187992
    Abstract: A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically withdrawing groups to modify the cinnamate moiety's electric properties as well as photo reactivities for the purpose of achieving a proper hydrolysis rate of the acyl bond between the biologically active molecule moiety and the cinnamic acid backbone. The biologically active molecule can be any biologically active agent or diagnostic, for example, a chemotherapeutic such as a paclitaxel, campotothecin, doxorubicin, amethopterin, etoposide, or fluconazole. The prodrug composition can be modified to add a carrier moiety on the prodrug composition for targeting or to facilitate uptake of the drug. The prodrug compositions can be activated with an energy source to release the drug at the desired site.
    Type: Application
    Filed: January 31, 2002
    Publication date: December 12, 2002
    Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper