Patents by Inventor Eleanor BARNES

Eleanor BARNES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115694
    Abstract: The invention relates to a multi-HBV immunogen viral vector vaccine comprising: a viral vector comprising an immunogen expression cassette, wherein the expression of a protein encoded by the expression cassette is arranged to be driven by a promoter, wherein the immunogen expression cassette encodes: a) HBV Core; b) a modified HBV polymerase (Pmut), wherein the modification is a mutation to wild-type HBV polymerase to substantially remove polymerase function; c) HBV surface antigen (HbsAg); and d) an intergenic sequence that is arranged to cause expression of at least the HBV surface antigen (HbsAg) as a separate protein from the HBV core and the modified HBV polymerase (Pmut), wherein the intergenic sequence is downstream (3?) of the sequences encoding the HBV core and the modified HBV polymerase (Pmut) and upstream (5?) of the sequence encoding the HBV surface antigen (HbsAg); and related compositions, vaccination methods and methods of treatment or prophylaxis of HBV infection.
    Type: Application
    Filed: June 6, 2023
    Publication date: April 11, 2024
    Inventors: Eleanor BARNES, Senthil CHINNAKANNAN
  • Publication number: 20230104363
    Abstract: The present invention relates to methods for assessing or obtaining an indication of vascular pressure associated with organs or visceral tissues of the body by using MRI imaging methods. The invention particularly relates to methods for assessing or obtaining an indication of portal hypertension using Magnetic Resonance T1, or T1 and T2* relaxometry, and T1, T2, and/or T2* mapping of the liver or spleen.
    Type: Application
    Filed: October 25, 2022
    Publication date: April 6, 2023
    Inventors: Michael PAVLIDES, Stefan NEUBAUER, Elizabeth TUNNICLIFFE, Eleanor BARNES, Rajarshi BANERJEE
  • Patent number: 11154613
    Abstract: The invention concerns a fusion polypeptide comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across: i) HCV genotypes 1a and 1b; ii) HCV genotypes 1 and 3; or iii) HCV genotypes 1 to 6; and wherein at least one of the conserved peptide sequences comprises at least part of a sequence of a non-structural protein of the HCV genotypes; including associated nucleic acid and vector sequences, and use in methods of treatment or prophylaxis, such as vaccination.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: October 26, 2021
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Eleanor Barnes, Annette Von Delft, Jose Lorenco
  • Publication number: 20210138063
    Abstract: The invention concerns a fusion polypeptide comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across: i) HCV genotypes 1a and 1b; ii) HCV genotypes 1 and 3; or iii) HCV genotypes 1 to 6; and wherein at least one of the conserved peptide sequences comprises at least part of a sequence of a non-structural protein of the HCV genotypes; including associated nucleic acid and vector sequences, and use in methods of treatment or prophylaxis, such as vaccination.
    Type: Application
    Filed: March 24, 2017
    Publication date: May 13, 2021
    Applicant: OXFORD UNIVERSITY INNOVATION LTD.
    Inventors: Eleanor Barnes, Annette VON DELFT, Jose LORENCO
  • Publication number: 20200138359
    Abstract: The present invention relates to methods for assessing or obtaining an indication of vascular pressure associated with organs or visceral tissues of the body by using MRI imaging methods. The invention particularly relates to methods for assessing or obtaining an indication of portal hypertension using Magnetic Resonance T1, or T1 and T2* relaxometry, and T1, T2 and/or T2* mapping of the liver or spleen.
    Type: Application
    Filed: January 6, 2020
    Publication date: May 7, 2020
    Inventors: Michael PAVLIDES, Stefan NEUBAUER, Elizabeth TUNNICLIFFE, Eleanor BARNES, Rajarshi BANERJEE
  • Publication number: 20200113998
    Abstract: The invention relates to a multi-HBV immunogen viral vector vaccine comprising: a viral vector comprising an immunogen expression cassette, wherein the expression of a protein encoded by the expression cassette is arranged to be driven by a promoter, wherein the immunogen expression cassette encodes: a) HBV Core; b) a modified HBV polymerase (Pmut), wherein the modification is a mutation to wild-type HBV polymerase to substantially remove polymerase function; c) HBV surface antigen (HbsAg); and d) an intergenic sequence that is arranged to cause expression of at least the HBV surface antigen (HbsAg) as a separate protein from the HBV core and the modified HBV polymerase (Pmut), wherein the intergenic sequence is downstream (3?) of the sequences encoding the HBV core and the modified HBV polymerase (Pmut) and upstream (5?) of the sequence encoding the HBV surface antigen (HbsAg); and related compositions, vaccination methods and methods of treatment or prophylaxis of HBV infection.
    Type: Application
    Filed: April 10, 2018
    Publication date: April 16, 2020
    Inventors: Eleanor BARNES, Senthil CHINNAKANNAN
  • Publication number: 20170027496
    Abstract: The present invention relates to methods for assessing or obtaining an indication of vascular pressure associated with organs or visceral tissues of the body by using MRI imaging methods. The invention particularly relates to methods for assessing or obtaining an indication of portal hypertension using Magnetic Resonance T1, or T1 and T2* relaxometry, and T1, T2 and/or T2* mapping of the liver or spleen.
    Type: Application
    Filed: April 7, 2015
    Publication date: February 2, 2017
    Inventors: Michael PAVLIDES, Stefan NEUBAUER, Elizabeth TUNNICLIFFE, Eleanor BARNES, Rajarshi BANERJEE