Patents by Inventor Eleanor Dagostino

Eleanor Dagostino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1)
    Publication number: 20050250742
    Abstract: Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.
    Type: Application
    Filed: March 3, 2004
    Publication date: November 10, 2005
    Inventors: Eleanor Dagostino, Liming Dong, Chuangxing Guo, Xinjun Hou, Stephen Margosiak
  • PIN1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design
    Publication number: 20040171019
    Abstract: Polypeptides containing the PIN1 peptidyl-prolyl isomerase domain but not containing the PIN1 WW domain are described. Also described are crystal structures of these polypeptides, including the crystal structure of a PIN1 PPIase:ligand complex. The structure coordinate data derived from these crystals provides a three-dimensional description of the substrate-binding site of PIN1 peptidyl-prolyl isomerase useful in drug discovery and design for the identification and design of modulators of PIN1 peptidyl-prolyl isomerase activity.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 2, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: David Matthews, Eleanor Dagostino, Rose Ann Ferre, Smita Gaur, Chuangxing Guo, Xinjun Hou, Stephen Margosiak, Barbara Mroczkowski, Grace Reiko Nakayama, Hans Parge, Jeff Zhu