Patents by Inventor Eleftherios Mylonakis

Eleftherios Mylonakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Auranofin-releasing antibacterial and antibiofilm polyurethane intravascular catheter coatings
    Patent number: 11931482
    Abstract: The invention provides an auranofin-releasing antibacterial and antibiofilm polyurethane (PU) catheter coating. Auranofin is an antirheumatic drug with recently identified antimicrobial properties.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: March 19, 2024
    Assignees: BROWN UNIVERSITY, Rhode Island Hospital
    Inventors: Anita Shukla, Beth Fuchs, Hanyang Liu, Eleftherios Mylonakis
  • Antibacterial and antifungal compounds
    Patent number: 11707442
    Abstract: The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. faecalis, E. faecium, B. subtilis, and B. anthracis. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. spp., K. pneumoniae, P. aeruginosa, A. baumannii, E. faecium, and E. faecalis. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. neoformans.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 25, 2023
    Assignees: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner
    Inventors: Helen Burgwyn Fuchs, Eleftherios Mylonakis, Frederick M. Ausubel, Raj Mohan Raja Muthiah, Wooseong Kim
  • Antibacterial compounds
    Patent number: 11690824
    Abstract: The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: July 4, 2023
    Assignees: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Emory University
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • Probiotic bacteria-directed prevention or treatment of fungal infection
    Patent number: 11478516
    Abstract: The invention provides a method and bacterial compositions for reducing or preventing an infection of a bodily tissue by a fungal microorganism by contacting the tissue with a composition comprising a purified Lactobacillus paracasei bacterium.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 25, 2022
    Assignees: RHODE ISLAND HOSPITAL, UNIVERSIDADE ESTADUAL PAULISTA/UNESP
    Inventors: Juliana Campos Junqueira, Helen Burgwyn Fuchs, Eleftherios Mylonakis
  • ANTIBIOTIC COMPOUNDS
    Publication number: 20220324796
    Abstract: The present application provides compounds and methods for treating bacterial infections, including bacterial infections caused by MRSA.
    Type: Application
    Filed: June 11, 2020
    Publication date: October 13, 2022
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • Methods for treating diseases or infections caused by or associated with using a halogenated salicylanilide
    Patent number: 11419834
    Abstract: Disclosed are methods for the prevention or treatment of a disease or infection caused by or associated with H. pylori in a subject infected by H. pylori, the method comprising orally administering a halogenated salicylanilide such as niclosamide to the subject. The method may be used for the prevention or treatment of, for example dyspepsia, gastritis, peptic ulcer disease, premalignant gastric lesions, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: August 23, 2022
    Assignee: RHODE ISLAND HOSPITAL
    Inventors: Eleftherios Mylonakis, Nagendran Tharmalingam
  • Antibiotic Compounds
    Publication number: 20220095614
    Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
    Type: Application
    Filed: November 23, 2021
    Publication date: March 31, 2022
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • Antibiotic compounds
    Patent number: 11278025
    Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: March 22, 2022
    Assignees: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Temple University-Of The Commonwealth System of Higher Education
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • Antibacterial Compounds
    Publication number: 20210251958
    Abstract: The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 19, 2021
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • AURANOFIN RELEASING ANTIBACTERIAL AND ANTIBIOFILM POLYURETHANE INTRAVASCULAR CATHETER COATINGS
    Publication number: 20200297898
    Abstract: The invention provides an auranofin-releasing antibacterial and antibiofilm polyurethane (PU) catheter coating. Auranofin is an antirheumatic drug with recently identified antimicrobial properties.
    Type: Application
    Filed: March 18, 2020
    Publication date: September 24, 2020
    Inventors: Anita Shukla, Beth Fuchs, Hanyang Liu, Eleftherios Mylonakis
  • METHODS FOR TREATING DISEASES OR INFECTIONS CAUSED BY OR ASSOCIATED WITH H. PYLORI USING A HALOGENATED SALICYLANILIDE
    Publication number: 20200268693
    Abstract: Disclosed are methods for the prevention or treatment of a disease or infection caused by or associated with H. Pylori in a subject infected by H. Pylori, the method comprising orally administering a halogenated salicylanilide such as niclosamide to the subject. The method may be used for the prevention or treatment of, for example dyspepsia, gastritis, peptic ulcer disease, premalignant gastric lesions, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
    Type: Application
    Filed: February 24, 2020
    Publication date: August 27, 2020
    Inventors: Eleftherios MYLONAKIS, Nagendran THARMALINGAM
  • Antibiotic Compounds
    Publication number: 20200190009
    Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
    Type: Application
    Filed: May 17, 2018
    Publication date: June 18, 2020
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • PROBIOTIC BACTERIA-DIRECTED PREVENTION OR TREATMENT OF FUNGAL INFECTION
    Publication number: 20190151382
    Abstract: The invention provides a method and bacterial compositions for reducing or preventing an infection of a bodily tissue by a fungal microorganism by contacting the tissue with a composition comprising a purified Lactobacillus paracasei bacterium.
    Type: Application
    Filed: July 31, 2017
    Publication date: May 23, 2019
    Inventors: Juliana Campos Junqueira, Helen Burgwyn Fuchs, Eleftherios Mylonakis
  • ANTIBACTERIAL AND ANTIFUNGAL COMPOUNDS
    Publication number: 20190054048
    Abstract: The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. faecalis, E. faecium, B. subtilis, and B. anthracis. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as Sa bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. spp., K. pneumoniae, P. aeruginosa, A. baumannii, E. faecium, and E. faecalis. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. neoformans.
    Type: Application
    Filed: September 23, 2016
    Publication date: February 21, 2019
    Applicants: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner
    Inventors: Helen Burgwyn FUCHS, Eleftherios MYLONAKIS, Frederick M. AUSUBEL, Raj Mohan Raja MUTHIAH, Wooseong KIM
  • Modified saponins for the treatment of fungal infections
    Patent number: 9629865
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: April 25, 2017
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • Modified Saponins For the Treatment of Fungal Infections
    Publication number: 20160228465
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 11, 2016
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • Modified saponins for the treatment of fungal infections
    Patent number: 9320751
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: April 26, 2016
    Assignees: The General Hospital Corporation, The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • Modified Saponins for the Treatment of Fungal Infections
    Publication number: 20150182544
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Application
    Filed: February 12, 2015
    Publication date: July 2, 2015
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • Modified saponins for the treatment of fungal infections
    Patent number: 8987217
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: March 24, 2015
    Assignees: The General Hospital Corporation, The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • Modified Saponins for the Treatment of Fungal Infections
    Publication number: 20130018007
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Application
    Filed: January 11, 2011
    Publication date: January 17, 2013
    Applicants: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel