Abstract: Systems and methods are disclosed herein for determining a diagnosis based on a base skin tone of a patient. In an embodiment, the system receives a base skin tone image of a patient, generates a calibrated base skin tone image by calibrating the base skin tone image using a reference calibration profile, and determines a base skin tone of the patient based on the calibrated base skin tone image. The system receives a concern image of a portion of the patient's skin, and selects a set of machine learning diagnostic models from a plurality of sets of candidate machine learning diagnostic models based on the base skin tone of the patient, each of the sets of candidate machine learning diagnostic models trained to receive the concern image and output a diagnosis of a condition of the patient.