Patents by Inventor Elena Appel

Elena Appel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric proteins and uses thereof
    Patent number: 8362206
    Abstract: The present invention provides a chimeric protein capable of killing or modifying a cell expressing abnormally high levels of a ligand of a receptor of the TNF/NGF family, comprising the amino acid sequence of at least one polypeptide consisting of an extracellular portion of said receptor connected to an effector molecule. In addition the invention provides pharmaceutical compositions comprising said chimeric protein and use thereof.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 29, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Elena Appel, Tanya Goncahrov
  • Method of treating a disease by administering caspase-8
    Patent number: 8318660
    Abstract: The invention relates to caspases and to extracellular use of caspases for regulating cell functions.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: November 27, 2012
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Elena Appel, Andrei Kovalenko, Rajput Akhill
  • COMPOSITIONS AND METHODS FOR TREATING ASPERGILLOSIS
    Publication number: 20120263719
    Abstract: The present invention provides monoclonal antibodies specific for members of the Aspergillus genus and uses thereof for increasing the survival rate of a subject infected with an Aspergillus species. The present invention also provides conjugates of alliinase with monoclonal antibodies specific for members of the Aspergillus genus that preserve the ability of the antibody to recognize the fungus as well as the activity of the enzyme to produce cytotoxic molecules of allicin from the substrate alliin. The invention further provides pharmaceutical compositions comprising the conjugates of the mAbs of the invention and alliinase and uses thereof in combination with the substrate alliin in the treatment of diseases cause by Aspergillus species, in particular invasive aspergillosis.
    Type: Application
    Filed: October 21, 2010
    Publication date: October 18, 2012
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: David Mirelman, Aharon Rabinkov, Elena Appel
  • Chimeric proteins, their preparation and pharmaceutical compositions containing them
    Patent number: 8092806
    Abstract: The present invention relates to a chimeric protein comprising a cell-targeting agent and a Yersinia outer protein, connected by a translocating polypeptide. The invention further relates to the preparation and use of such chimeric protein.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: January 10, 2012
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Elena Appel
  • USE OF CASPASES FOR THE PREPARATION OF MEDICAMENTS
    Publication number: 20090104175
    Abstract: The invention relates to caspases and to extracellular use of caspases for regulating cell functions.
    Type: Application
    Filed: March 3, 2007
    Publication date: April 23, 2009
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: David Wallach, Elena Appel, Andrei Kovalenko, Rajput Akhil
  • Chimeric Proteins, Their Preparation and Pharmaceutical Compositions Containing Them
    Publication number: 20080287356
    Abstract: The present invention relates to a chimeric protein comprising a cell-targeting agent and a Yersinia outer protein, connected by a translocating polypeptide. The invention further relates to the preparation and use of such chimeric protein.
    Type: Application
    Filed: April 10, 2006
    Publication date: November 20, 2008
    Inventors: David Wallach, Elena Appel