Patents by Inventor Elena Brasola

Elena Brasola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE 2-FLUORO-3-NITROTOLUENE AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20210292271
    Abstract: The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I), and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula (II) or salts thereof by means of the crystalline 2-fluoro-3-nitrotoluene.
    Type: Application
    Filed: July 3, 2019
    Publication date: September 23, 2021
    Inventors: Elena Brasola, Marco Di Silvestro
  • Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
    Patent number: 10913747
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: February 9, 2021
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Ottorino De Lucchi, Pierluigi Padovan, Elena Brasola
  • EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID
    Publication number: 20200157109
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 21, 2020
    Applicant: F.I.S. - FABBRiCA ITALIANA SINTETICI S.P.A.
    Inventors: Ottorino DE LUCCHI, Pierluigi PADOVAN, Elena BRASOLA
  • Dimer impurities of Apixaban and method to remove them
    Patent number: 10590133
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 17, 2020
    Assignee: F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi, Loris Peruzzi
  • DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM
    Publication number: 20190367509
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 5, 2019
    Inventors: Elena BRASOLA, Filippo Tomasi, Loris Peruzzi
  • Dimer impurities of apixaban and method to remove them
    Patent number: 10385049
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: August 20, 2019
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi, Loris Peruzzi
  • Key intermediates and impurities of the synthesis of Apixaban: Apixaban glycol esters
    Patent number: 10040793
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: August 7, 2018
    Assignee: F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi
  • DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM
    Publication number: 20180118737
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Application
    Filed: July 18, 2016
    Publication date: May 3, 2018
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena BRASOLA, Filippo TOMASI, Loris PERUZZI
  • KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
    Publication number: 20180086759
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Application
    Filed: November 30, 2017
    Publication date: March 29, 2018
    Inventors: Elena BRASOLA, Filippo TOMASI
  • Key intermediates and impurities of the synthesis of apixaban: apixaban glycol esters
    Patent number: 9920051
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 20, 2018
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi
  • Key intermediates and impurities of the synthesis of Apixaban: Apixaban glycol esters
    Patent number: 9624221
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: April 18, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A
    Inventors: Elena Brasola, Filippo Tomasi
  • KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
    Publication number: 20170001999
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban kinetic Apixaban are also identified and quantified.
    Type: Application
    Filed: February 18, 2015
    Publication date: January 5, 2017
    Inventors: Elena BRASOLA, Filippo TOMASI
  • KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
    Publication number: 20160326171
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 10, 2016
    Inventors: Elena BRASOLA, Filippo TOMASI
  • Process for the preparation of ?-alkoxycarbonyllysines and their analogues
    Patent number: 8026372
    Abstract: A process for the preparation of ?-alkoxycarbonylamino-?-aminoacids and ?,? orthogonally diprotected diaminoacids from ?,?-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ?-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ?-alkoxycarbonylamino-?-aminoacids with benzotriazoles are also disclosed.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: September 27, 2011
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Siro Serafini, Riccardo Motterle, Elena Brasola
  • PROCESS FOR THE PREPARATION OF EPSILON -ALKOXYCARBONYLLYSINES AND THEIR ANALOGUES
    Publication number: 20090312557
    Abstract: A process for the preparation of ?-alkoxycarbonylamino-?-aminoacids and ?,? orthogonally diprotected diaminoacids from ?,?-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ?-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ?-alkoxycarbonylamino-?-aminoacids with benzotriazoles are also disclosed.
    Type: Application
    Filed: August 4, 2006
    Publication date: December 17, 2009
    Inventors: Siro Serafini, Riccardo Motterle, Elena Brasola