Patents by Inventor Elena CASTELLANOS-RIZALDOS

Elena CASTELLANOS-RIZALDOS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SILENCING VEGF-A EXPRESSION
    Publication number: 20230136787
    Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting VEGF-A, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of VEGF-A.
    Type: Application
    Filed: February 9, 2021
    Publication date: May 4, 2023
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: JAMES D. MCININCH, MARK KEATING, MARK K. SCHLEGEL, ADAM CASTORENO, VASANT R. JADHAV, CHARALAMBOS KAITTANIS, ELENA CASTELLANOS-RIZALDOS, BHAUMIK A. PANDYA
  • Methods and compositions to detect mutations in plasma using exosomal RNA and cell free DNA from non-small cell lung cancer patients
    Patent number: 11427864
    Abstract: The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 30, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Elena Castellanos-Rizaldos, Vasisht Tadigotla, Dominik Grimm, Xuan Zhang, Wei Yu
  • METHODS FOR DEVELOPING URINE BIOMARKERS AND FOR DETECTING BLADDER CANCER
    Publication number: 20210230701
    Abstract: The present disclosure relates to methods for detecting and treating bladder cancer in a subject using the gene expression level measurements from exosomes derived from the subject.
    Type: Application
    Filed: June 6, 2019
    Publication date: July 29, 2021
    Inventors: Robert KITCHEN, Elena CASTELLANOS-RIZALDOS, Mia SHER, James HURLEY, Dalin CHAN, Georg STOLL, Wei YU, Johan SKOG
  • METHODS AND COMPOSITIONS TO DETECT MUTATIONS IN PLASMA USING EXOSOMAL RNA AND CELL FREE DNA FROM NON-SMALL CELL LUNG CANCER PATIENTS
    Publication number: 20190376128
    Abstract: The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
    Type: Application
    Filed: November 17, 2017
    Publication date: December 12, 2019
    Inventors: Johan Karl Olov SKOG, Elena CASTELLANOS-RIZALDOS, Vasisht TADIGOTLA, Dominik GRIMM, Xuan ZHANG, Wei YU
  • PLASMA-BASED DETECTION OF ANAPLASTIC LYMPHOMA KINASE (ALK) NUCLEIC ACIDS AND ALK FUSION TRANSCRIPTS AND USES THEREOF IN DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20190093172
    Abstract: The present invention relates generally to the field of biomarker analysis, particularly determining gene expression signatures from biological samples, including plasma samples.
    Type: Application
    Filed: April 17, 2017
    Publication date: March 28, 2019
    Applicant: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov SKOG, Mikkel NOERHOLM, James HURLEY, Elena CASTELLANOS-RIZALDOS, Kay BRINKMAN