Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.

Abstract: Some embodiments of the invention include a synthetic biocidal surface comprising an array of disordered nanospikes. The biocidal surface may be lethal to cells on said surface due to piercing of cell membranes by said nanospikes. Some embodiments may include a method of producing a synthetic biocidal surface comprising an array of disordered nanospikes that may include exposing a silicon comprising substrate surface to reactive-ion etching.

Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.

Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.

Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.

Abstract: Some embodiments of the invention include a synthetic biocidal surface comprising an array of disordered nanospikes. The biocidal surface may be lethal to cells on said surface due to piercing of cell membranes by said nanospikes. Some embodiments may include a method of producing a synthetic biocidal surface comprising an array of disordered nanospikes that may include exposing a silicon comprising substrate surface to reactive-ion etching.

Abstract: The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.

Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.

Abstract: The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.

Abstract: The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.

Abstract: The invention relates to materials that exhibit biocidal activity and in particular to surfaces that exhibit novel surface topography that is lethal to cells on contact. The invention also relates to devices comprising such surfaces, to methods of producing the surfaces and to methods of eliminating or reducing cellular survival wherein cells are exposed to the surfaces. In particular the invention relates to a synthetic biocidal surface comprising an array of nanospikes that are lethal to cells on said surface due to piercing of cell membranes by said nanospikes and to a method of producing a synthetic biocidal surface comprising an array of nanospikes that are lethal to cells on said surface due to piercing of cell membranes by said nanospikes, which comprises exposing a silicon comprising substrate surface to reactive-ion etching.

Abstract: The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.

Abstract: Systems and methods (“utility”) for sorting a plurality of complex objects are provided herein. The utility may include a sorting algorithm that sorts references to the complex objects, rather than the complex objects themselves, such that the need to copy and swap complex objects in their locations in memory is reduced. Further, the sorting algorithm may utilize a recursive divide and conquer process, using multiple pivot elements at each sorting level. For example, the sorting algorithm is based on a modified Quicksort algorithm that uses multiple pivot elements at each level to sort an array of references that point to complex objects.

Abstract: An imaging system is provided, having a housing, an inlet opening receiving radiation from objects and an optical system. The optical system includes a reception channel for visible radiation, an infra-red radiation channel, a channel of the laser range finder having a laser radiation source, a photoreceptor and spectral splitters. All channels are optically coupled to one another. An optical element made from a material that transmits the radiation in the working range of the photoreceptor and is inserted into the inlet opening to hermetically seal the system. The reception channel for the visible radiation and the infra-red radiation channel are constructed as an optoelectronic multichannel system having at least two channels, the optical axes of which coincide and are situated inside the inlet opening.

Abstract: Systems and methods (“utility”) for sorting a plurality of complex objects are provided herein. The utility may include a sorting algorithm that sorts references to the complex objects, rather than the complex objects themselves, such that the need to copy and swap complex objects in their locations in memory is reduced. Further, the sorting algorithm may utilize a recursive divide and conquer process, using multiple pivot elements at each sorting level. For example, the sorting algorithm is based on a modified Quicksort algorithm that uses multiple pivot elements at each level to sort an array of references that point to complex objects.

Abstract: Micro/nano-structures fabricated by laser ablation and suitable for use in micro-arrays and micro-assays are described. In particular, micro-structures having combinatorial surfaces that allow molecules to attach to a localised area of the surface according to the characteristics of the localised area. Methods of fabricating such micro/nano-structures and their use in micro-arrays and micro-assays is also described.