Publication number: 20230173003
Abstract: A composition, in particular in gel form, includes Lactobacillaceae reuteri to be used in the prevention and/or treatment of oral mucositis, particularly radio-induced oral mucositis. In its gel form, the composition also includes: a polyoxy-alkylene copolymer, in particular a polyoxy-ethylene-propylene copolymer, preferably with the general formula HO[CH2CH2O]x[CH2CH(CH3)O]y[CH2CH2O]zH, where preferably x=99, y=67, and z=99; a mucoadhesive polymer, preferably cellulosic in nature, in particular carboxymethyl cellulose; and one or more stabilizers, preferably chosen from sugars such as sucrose, trehalose, mannitol, sorbitol and glucose, sodium ascorbate, very preferably the sugar is sucrose. Treatments of other mucositis with the composition, such as intestinal leakage, are conceivable. A procedure to produce the composition in gel and lyophilized form is described.
Type:
Application
Filed:
September 9, 2022
Publication date:
June 8, 2023
Applicant:
MAGI EUREGIO SCS
Inventors:
Matteo Bertelli, Elena Manara, Paolo Enrico Maltese, Stefano Cecchin, Giuseppe Marceddu, Kyrylo Anpilogov, Stefano Paolacci, Daniele Malacarne, Teresa Zelante, Stefano Giovagnoli, Debora Caricato, Leonardo Brizzi