Patents by Inventor Elena Sotillo

Elena Sotillo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO IMPROVE T CELL EFFICACY AND SAFETY BY MODULATING MEDIATORS OF PHAGOCYTOSIS
    Publication number: 20240207314
    Abstract: Provided herein are engineered lymphocytes which overexpress one or more anti-phagocytic signaling proteins, and methods of using same to induce an immune response against cancer cells by inhibiting immune clearance of the engineered T cells. Also provided is a method of depleting engineered T cells in a subject by administering to the subject an agent that inhibits the activity of one or more anti-phagocytic signaling proteins expressed by the engineered T cells.
    Type: Application
    Filed: April 29, 2022
    Publication date: June 27, 2024
    Inventors: Johanna Lena Theruvath, Crystal Mackall, Elena Sotillo
  • Compositions and Methods for Inhibiting T Cell Exhaustion
    Publication number: 20220401486
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides T cells that are modified (e.g., genetically and/or functionally) to maintain functionality under conditions in which unmodified T cells display exhaustion. Compositions and methods disclosed herein find use in preventing exhaustion of engineered (e.g., chimeric antigen receptor (CAR) T cells) as well as non-engineered T cells thereby enhancing T cell function (e.g., activity against cancer or infectious disease).
    Type: Application
    Filed: June 27, 2022
    Publication date: December 22, 2022
    Inventors: Crystal Mackall, Rachel Lynn, Evan Weber, Elena Sotillo
  • Compositions and methods for inhibiting T cell exhaustion
    Patent number: 11400117
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides T cells that are modified (e.g., genetically and/or functionally) to maintain functionality under conditions in which unmodified T cells display exhaustion. Compositions and methods disclosed herein find use in preventing exhaustion of engineered (e.g., chimeric antigen receptor (CAR) T cells) as well as non-engineered T cells thereby enhancing T cell function (e.g., activity against cancer or infectious disease).
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: August 2, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Crystal Mackall, Rachel Lynn, Evan Weber, Elena Sotillo
  • Compositions and methods for transient up-regulation of Myc in B-cell lymphomas for enhancing P53 independent apoptotic responses to chemotherapy
    Patent number: 10751356
    Abstract: Compositions and methods useful for the treatment of cancer, particularly lymphoma, are disclosed.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 25, 2020
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Andrei Thomas-Tikhonenko, Elena Sotillo-Pineiro
  • COMPOSITIONS AND METHODS FOR INHIBITING T CELL EXHAUSTION
    Publication number: 20190183932
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides T cells that are modified (e.g., genetically and/or functionally) to maintain functionality under conditions in which unmodified T cells display exhaustion. Compositions and methods disclosed herein find use in preventing exhaustion of engineered (e.g., chimeric antigen receptor (CAR) T cells) as well as non-engineered T cells thereby enhancing T cell function (e.g., activity against cancer or infectious disease).
    Type: Application
    Filed: December 14, 2018
    Publication date: June 20, 2019
    Inventors: Crystal Mackall, Rachel Lynn, Evan Weber, Elena Sotillo
  • COMPOSITIONS AND METHODS FOR TREATING B-LYMPHOID MALIGNANCIES
    Publication number: 20170239294
    Abstract: Compositions and methods for inhibiting, treating, and/or preventing a B-cell neoplasm are provided.
    Type: Application
    Filed: October 15, 2015
    Publication date: August 24, 2017
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrei Thomas-Tikhonenko, Stephan Grupp, John Maris, David Barrett, Elena Sotillo-Pineiro
  • COMPOSITIONS AND METHODS FOR TRANSIENT UP-REGULATION OF MYC IN B-CELL LYMPHOMAS FOR ENHANCING P53 INDEPENDENT APOPTOTIC RESPONSES TO CHEMOTHERAPY
    Publication number: 20160095873
    Abstract: Compositions and methods useful for the treatment of cancer, particularly lymphoma, are disclosed.
    Type: Application
    Filed: October 5, 2015
    Publication date: April 7, 2016
    Inventors: Andrei Thomas-Tikhonenko, Elena Sotillo-Pineiro