Patents by Inventor Elena Tonti

Elena Tonti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines comprising bisphosphonate and methods of use thereof
    Patent number: 10188733
    Abstract: The present invention demonstrates that bisphosphonates have an intrinsic adjuvant activity and directly stimulate B cell antibody secretion. Accordingly, the present invention provides vaccines comprising a bisphosphonate, methods for stimulating an immune response, enhancing the immunogenicicty of an immunogen, and methods of treating an infection, an autoimmune disease, an allergy, and/or a cancer using the same.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: January 29, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Ulrich H. von Andrian, Matteo Iannacone, Elena Tonti, Elliott Ashley Moseman
  • Adjuvant incorporation in immunoanotherapeutics
    Patent number: 9439859
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: September 13, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Presidents and Fellows of Harvard College
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Targeting of antigen presenting cells with immunonanotherapeutics
    Patent number: 9308280
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: April 12, 2016
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich H. von Andrian, Elena Tonti
  • Adjuvant incorporation in immunonanotherapeutics
    Patent number: 9233072
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: January 12, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hosptial, Inc., President and Fellows of Harvard College
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Nicotine immunonanotherapeutics
    Patent number: 8932595
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 13, 2015
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Matteo Iannacone, Ulrich von Andrian, Omid C. Farokhzad, Frank Alexis, Pamela Basto, Jinjun Shi, Elliott Ashley Moseman, Robert S. Langer, Elena Tonti
  • Immunonanotherapeutics that provide IGG humoral response without T-cell antigen
    Patent number: 8906381
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing, and using such nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 9, 2014
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Matteo Iannacone, Frank Alexis, Pamela Basto, Elliott Ashley Moseman, Jinjun Shi, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
  • Adjuvant Incorporation in Immunonanotherapeutics
    Publication number: 20140127301
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 8, 2014
    Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Targeting of Antigen Presenting Cells With Immunonanotherapeutics
    Publication number: 20140037736
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 4, 2013
    Publication date: February 6, 2014
    Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich H. von Andrian, Elena Tonti
  • Adjuvant incorporation in immunonanotherapeutics
    Patent number: 8637028
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 28, 2014
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Nicotine immunonanotherapeutics
    Patent number: 8591905
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: November 26, 2013
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Ulrich von Andrian, Omid C. Farokhzad, Frank Alexis, Matteo Iannacone, Pamela Basto, Jinjun Shi, Elliott Ashley Moseman, Robert S. Langer, Elena Tonti
  • VACCINES COMPRISING BISPHOSPHONATE AND METHODS OF USE THEREOF
    Publication number: 20130309270
    Abstract: The present invention demonstrates that bisphosphonates have an intrinsic adjuvant activity and directly stimulate B cell antibody secretion. Accordingly, the present invention provides vaccines comprising a bisphosphonate, methods for stimulating an immune response, enhancing the immunogenicicty of an immunogen, and methods of treating an infection, an autoimmune disease, an allergy, and/or a cancer using the same.
    Type: Application
    Filed: October 21, 2011
    Publication date: November 21, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Ulrich H. von Andrian, Matteo Iannacone, Elena Tonti, Elliott Ashley Moseman
  • Targeting of antigen presenting cells with immunonanotherapeutics
    Patent number: 8562998
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: October 22, 2013
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
  • Adjuvant Incorporation in Immunonanotherapeutics
    Publication number: 20130129790
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 12, 2012
    Publication date: May 23, 2013
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich Von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Targeting of antigen presenting cells with immunonanotherapeutics
    Patent number: 8343497
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: January 1, 2013
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
  • Adjuvant incorporation in immunonanotherapeutics
    Patent number: 8343498
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: January 1, 2013
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
    Patent number: 8277812
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: October 2, 2012
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Matteo Iannacone, Frank Alexis, Pamela Basto, Elliott Ashley Moseman, Jinjun Shi, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
  • IMMUNONANOTHERAPEUTICS THAT PROVIDE IgG HUMORAL RESPONSE WITHOUT T-CELL ANTIGEN
    Publication number: 20120087890
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing maceutical compositions thereof.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 12, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Matteo Iannacone, Frank Alexis, Pamela Basto, Elliott Ashley Moseman, Jinjun Shi, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
  • ADJUVANT INCORPORATION IN IMMUNONANOTHERAPEUTICS
    Publication number: 20110268805
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 9, 2009
    Publication date: November 3, 2011
    Inventors: Frank Alexis, Matteo Iannacone, Jinjin Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • TARGETING OF ANTIGEN PRESENTING CELLS WITH IMMUNONANOTHERAPEUTICS
    Publication number: 20110268804
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.
    Type: Application
    Filed: October 9, 2009
    Publication date: November 3, 2011
    Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti