Patents by Inventor Elena TRIFONOV

Elena TRIFONOV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Toll-like receptor 4 (TLR4) inhibitors and use thereof
    Patent number: 11925643
    Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 12, 2024
    Assignees: MOR RESEARCH APPLICATIONS LTD., BAR-ILAN UNIVERSITY
    Inventors: Edith Hochhauser, Arie-Lev Gruzman, Elena Trifonov
  • TOLL-LIKE RECEPTOR 4 (TLR4) INHIBITORS AND USE THEREOF
    Publication number: 20210196717
    Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 1, 2021
    Inventors: Edith HOCHHAUSER, Arie-Lev GRUZMAN, Elena TRIFONOV